Patents by Inventor Noureddine Fahmi

Noureddine Fahmi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Beta-Cyclodextrin Derivatives as Antibacterial Agents
    Publication number: 20110071108
    Abstract: The invention provides a new class of antibiotics to which pathogenic bacteria have not been exposed, and thus should not have developed resistance. This new class of antibiotics are derivatives of ?-cyclodextrin (?-CD), which is a cyclic molecule comprising seven D-glucose units.
    Type: Application
    Filed: May 3, 2010
    Publication date: March 24, 2011
    Applicant: Pinnacle Pharmaceuticals, Inc.
    Inventors: Noureddine Fahmi, Frank Werner Schmidtmann, Sidney Hecht
  • ?-Cyclodextrin derivatives
    Patent number: 7851457
    Abstract: The invention provides low molecular weight compounds that block the pore formed by protective antigen and inhibit anthrax toxin action. Structures of the compounds are derivatives of ?-cyclodextrin. Per-substituted alkylamino derivates displayed inhibitory activity, and they were protective against anthrax lethal toxin action at low micromolar concentrations. Also, the addition of one of the alkylamino derivatives to the bilayer lipid membrane with multiple PA channels caused a significant decrease in membrane conductance. Thus, the invention also provides methods for protection against anthrax toxicity.
    Type: Grant
    Filed: January 28, 2005
    Date of Patent: December 14, 2010
    Assignee: Innovative Biologics, Inc.
    Inventors: Sidney Hecht, Vladimir Karginov, Noureddine Fahmi
  • ?-cyclodextrin derivatives as antibacterial agents
    Patent number: 7737132
    Abstract: The invention provides a new class of antibiotics to which pathogenic bacteria have not been exposed, and thus should not have developed resistance. This new class of antibiotics are derivatives of ?-cyclodextrin (?-CD), which is a cyclic molecule comprising seven D-glucose units.
    Type: Grant
    Filed: January 27, 2006
    Date of Patent: June 15, 2010
    Assignee: Pinnacle Pharmaceuticals
    Inventors: Noureddine Fahmi, Frank Werner Schmidtmann, Sidney Hecht
  • B-CYCLODEXTRIN DERIVATIVES AND THEIR USE AGAINST ANTHRAX LETHAL TOXIN
    Publication number: 20090023210
    Abstract: The invention provides low molecular weight compounds that block the pore formed by protective antigen and inhibit anthrax toxin action. Structures of the compounds are derivatives of ?-cyclodextrin. Per-substituted alkylamino derivatives displayed inhibitory activity, and they were protective against anthrax lethal toxin action at low micromolar concentrations. Also, the addition of one of the alkylamino derivatives to the bilayer lipid membrane with multiple PA channels caused a significant decrease in membrane conductance. Thus, the invention also provides methods for protection against anthrax toxicity.
    Type: Application
    Filed: March 7, 2008
    Publication date: January 22, 2009
    Inventors: VLADIMIR KARGINOV, Sidney Hecht, Noureddine Fahmi, Ken Alibek
  • B-CYCLODEXTRIN DERIVATIVES AND THEIR USE AGAINST ANTHRAX LETHAL TOXIN
    Publication number: 20090005343
    Abstract: The invention provides low molecular weight compounds that block the pore formed by protective antigen and inhibit anthrax toxin action. Structures of the compounds are derivatives of ?-cyclodextrin. Per-substituted alkylamino derivatives displayed inhibitory activity, and they were protective against anthrax lethal toxin action at low micromolar concentrations. Also, the addition of one of the alkylamino derivatives to the bilayer lipid membrane with multiple PA channels caused a significant decrease in membrane conductance. Thus, the invention also provides methods for protection against anthrax toxicity.
    Type: Application
    Filed: March 7, 2008
    Publication date: January 1, 2009
    Inventors: Sidney Hecht, Noureddine Fahmi
  • B-cyclodextrin derivatives and their use against anthrax lethal toxin
    Publication number: 20060247208
    Abstract: The invention provides low molecular weight compounds that block the pore formed by protective antigen and inhibit anthrax toxin action. Structures of the compounds are derivatives of ?-cyclodextrin. Per-substituted alkylamino derivates displayed inhibitory activity, and they were protective against anthrax lethal toxin action at low micromolar concentrations. Also, the addition of one of the alkylamino derivatives to the bilayer lipid membrane with multiple PA channels caused a significant decrease in membrane conductance. Thus, the invention also provides methods for protection against anthrax toxicity.
    Type: Application
    Filed: January 28, 2005
    Publication date: November 2, 2006
    Inventors: Vladimir Karginov, Sidney Hecht, Noureddine Fahmi, Ken Alibek
  • Beta-cyclodextrin derivatives as antibacterial agents
    Publication number: 20060199785
    Abstract: The invention provides a new class of antibiotics to which pathogenic bacteria have not been exposed, and thus should not have developed resistance. This new class of antibiotics are derivatives of ?-cyclodextrin (?-CD), which is a cyclic molecule comprising seven D-glucose units.
    Type: Application
    Filed: January 27, 2006
    Publication date: September 7, 2006
    Inventors: Noureddine Fahmi, Frank Schmidtmann, Sidney Hecht