Abstract: An implantable endoluminal prosthesis is described for use in the treatment of aneurysm involving branches. The prosthesis has a multilayer configuration, including a self-expandable braided framework extending along an axis and able to expand from a radially compressed state in a delivery configuration to a radially expanded state. The self-expandable braided framework is formed by wires, is devoid of any impermeable cover layer, includes a plurality of layers of wires made of biocompatible material, and forms a wall of the endoluminal prosthesis. Each layer forms a mesh, the meshes forming a lattice and being interlocked, the wires being integrated in the mesh of at least one of the adjacent layers. The self-expandable braided framework has a cylindrical lumen. The ratio of the surface coverage ratio of the outer layer to the surface coverage ratio of the inner layer is at least 1.5.

Abstract: The present disclosure refers to an implantable endoluminal prosthesis for use in the treatment of aneurysm involving branches having a multilayer configuration, comprising at least one self-expandable braided framework extending along an axis able to expand from a radially compressed state in a delivery configuration to a radially expanded state; the self-expandable braided framework being formed with at most 196 wires having a given wire diameter (ø21); this self-expandable braided framework devoid of any impermeable cover layer, comprising a plurality of layers of wires made of biocompatible material; and forming a wall of the endoluminal prosthesis; each layer forming a mesh; the meshes forming a lattice with a plurality of wires of said layers; the meshes being interlocked, the wires being integrated in the mesh of at least one of the adjacent layers; the self-expandable braided framework comprising a lumen in a cylindrical form with a circular cross-section and a constant diameter; characterized in that

Abstract: An implantable endoluminal prosthesis for use in the treatment of aneurysm involving branches is described, where at least one self-expandable braided framework extending along an axis is able to expand from a radially compressed state in a delivery configuration to a radially expanded state. The self-expandable braided framework includes a plurality of layers of wires made of biocompatible material forming a lattice with a plurality of wires of said layers; the wires being integrated in the mesh of at least one of the adjacent layers; the self-expandable braided framework including a lumen in a cylindrical form; characterized in that, in radially expanded state, a ratio of a thickness of a wall of the implantable endoluminal prosthesis in the radially expanded state to the diameter of wire being greater than 3.0; and the surface coverage ratio (SCR) of the braided framework is at least 30% and at most 50%.

Abstract: A multi-lumen stent assembly (100) for deployment in a bifurcated vessel. This assembly is made of a self-expandable main body component (200) and two lumen extensions (300), able to be inserted into one of the lumens of a double-barrelled portion (208) of the main body component (200). The main body component (200) has a proximal end (201) configured to be placed toward the heart and a distal end (202). The main body component (200) has a main body portion (203), a concaved portion (206), and a transition portion (205). The main body portion (203) has a cylindrical lumen (204) of constant diameter. The concaved portion (206) has a double-barrelled portion (208) having two lumens (211). A cross-section of the transition portion (205) evolving from a circular shape to an elliptical shape towards the transition portion (205), a larger diameter of this shape being in a central plane (CP).

Abstract: An implantable permanent filter assembly (1) for deployment in a bifurcated vessel includes a main vessel and at least two branches. This assembly includes a filtering sleeve (2) formed of an expendable braided framework (20) able to expand from a radially compressed state in a delivery configuration to a radially expanded state. The filtering sleeve extends along an axis and defines a cylindrical lumen devoid of impermeable layer, having a distal end configured to extend toward the branches of the bifurcated vessel and a proximal end configured to extend toward away from the branches of the bifurcated vessel. The braided framework has a plurality of mesh layers (22,23,24) of wires (25) made of biocompatible material, forming a lattice with a plurality of wires of each layers. The lattice, when observed normal with respect to a wall of the implantable endoluminal prosthesis, defines polygonal openings.

Abstract: The present invention relates to implantable endoluminal prosthesis for preventing stroke. The endoluminal prosthesis (1) consists of a braided framework (20) defining a cylindrical lumen (21) devoid of impermeable membrane. Said braided framework (20) is self-expandable comprising a plurality of layers (22, 23, 24) of wires (25) made of biocompatible material. Each layer forms a mesh. The meshes form a lattice with a plurality of wires (2) of given layers (22, 23, 24). The lattice defines polygonal opening units (26) when observed normal to a wall of the implantable endoluminal prosthesis (1). The diameter (Ø25) of wire (25) being at least 30 ?m and at most 150 ?m, the mean diameter (Ø27) of the inscribed circle (27) of the polygonal opening units (26) being at least 75 ?m and at most 200 ?m in fully expanded state. The braided framework (20) consists of at least 128 and at most 512 wires (25).

Abstract: The invention relates to an implantable endoluminal prosthesis and a method of using such devices for treatment of a valve dysfunction involving ascending aneurysm. The prosthesis is designed for deployment from the aortic annulus to the aorta. It comprises a self-expandable braided framework able to expand from a radially compressed state in a delivery configuration to a radially expanded state. This framework is formed of braided wires and has a proximal end configured to extend toward the heart and a distal end configured to extent toward away from the heart. The self-expandable braided framework extends along an axis. The framework has a main tubular body of cylindrical form of circular cross-section and at a distal end, a neck the diameter of which is smaller than the one of the self-expandable braided framework, and a transition portion extending between the proximal end of the main tubular body and the distal end of the neck.

Abstract: The present invention refers to an implantable endoluminal prosthesis for use in the treatment of aneurysm involving branches having a multilayer configuration, comprising at least one self-expandable braided framework extending along an axis able to expand from a radially compressed state in a delivery configuration to a radially expanded state; the self-expandable braided framework being formed with at most 196 wires having a given wire diameter (Ø21); this self-expandable braided framework devoid of any impermeable cover layer, comprising a plurality of layers of wires made of biocompatible material; and forming a wall of the endoluminal prosthesis; each layer forming a mesh; the meshes forming a lattice with a plurality of wires of said layers; the meshes being interlocked, the wires being integrated in the mesh of at least one of the adjacent layers; the self-expandable braided framework comprising a lumen in a cylindrical form with a circular cross-section and a constant diameter; characterized in that,

Abstract: An intraluminal apparatus for delivering a self-expanding stent which extends along a longitudinal axis from a proximal side to a distal side. It comprises in delivery configuration (a) a retracting sheath having a lumen along its longitudinal axis and slidably covering a stent receiving region at the distal end of the lumen, (b) an inner shaft longitudinally disposed in the intraluminal apparatus, at least a distal portion of the inner shaft being disposed within the sheath, (c) the self-expanding stent in a compressed state disposed within the stent receiving region of the lumen, (d) a holding means delimitating an inner cavity, disposed adjacent to a proximal side of the stent in the sheath, the proximal end of the holding means being permanently joined to the inner shaft, and (e) a handling means placed towards the proximal side of the intraluminal apparatus, able to displace longitudinally the retracting sheath with respect to the inner shaft.

Abstract: An implantable permanent filter assembly (1) for deployment in a bifurcated vessel includes a main vessel and at least two branches. This assembly includes a filtering sleeve (2) formed of an expendable braided framework (20) able to expand from a radially compressed state in a delivery configuration to a radially expanded state. The filtering sleeve extends along an axis and defines a cylindrical lumen devoid of impermeable layer, having a distal end configured to extend toward the branches of the bifurcated vessel and a proximal end configured to extend toward away from the branches of the bifurcated vessel. The braided framework has a plurality of mesh layers (22,23,24) of wires (25) made of biocompatible material, forming a lattice with a plurality of wires of each layers. The lattice, when observed normal with respect to a wall of the implantable endoluminal prosthesis, defines polygonal openings.

Abstract: The present invention relates to implantable endoluminal prostheses and methods of using such devices in preventing clots migration to avoid ischemic strokes. The implantable endoluminal prosthesis is suitable for deployment from the aortic annulus to the aorta and comprises a self-expandable braided framework able to expand from a radially compressed state in a delivery configuration to a radially expanded state, and a radially collapsible valve body comprising an impermeable material. The self-expandable braided framework is formed of braided wires having a given diameter, and has a proximal end configured to extend toward the heart and a distal end configured to extent toward away from the heart and extending along an axis.

Abstract: The present invention relates to implantable endoluminal prosthesis for preventing stroke. The endoluminal prosthesis (1) consists of a braided framework (20) defining a cylindrical lumen (21) devoid of impermeable membrane. Said braided framework (20) is self-expandable comprising a plurality of layers (22, 23, 24) of wires (25) made of biocompatible material. Each layer forms a mesh. The meshes form a lattice with a plurality of wires (2) of given layers (22, 23, 24). The lattice defines polygonal opening units (26) when observed normal to a wall of the implantable endoluminal prosthesis (1). The diameter (Ø25) of wire (25) being at least 30 ?m and at most 150 ?m, the mean diameter (Ø27) of the inscribed circle (27) of the polygonal opening units (26) being at least 75 ?m and at most 200 ?m in fully expanded state. The braided framework (20) consists of at least 128 and at most 512 wires (25).

Abstract: A multi-lumen stent assembly (100) for deployment in a bifurcated vessel. This assembly is made of a self-expandable main body component (200) and two lumen extensions (300), able to be inserted into one of the lumens of a double-barrelled portion (208) of the main body component (200). The main body component (200) has a proximal end (201) configured to be placed toward the heart and a distal end (202). The main body component (200) has a main body portion (203), a concaved portion (206), and a transition portion (205). The main body portion (203) has a cylindrical lumen (204) of constant diameter. The concaved portion (206) has a double-barrelled portion (208) having two lumens (211). A cross-section of the transition portion (205) evolving from a circular shape to an elliptical shape towards the transition portion (205), a larger diameter of this shape being in a central plane (CP).

Abstract: An intraluminal apparatus for delivering a self-expanding stent which extends along a longitudinal axis from a proximal side to a distal side. It comprises in delivery configuration (a) a retracting sheath having a lumen along its longitudinal axis and slidably covering a stent receiving region at the distal end of the lumen, (b) an inner shaft longitudinally disposed in the intraluminal apparatus, at least a distal portion of the inner shaft being disposed within the sheath, (c) the self-expanding stent in a compressed state disposed within the stent receiving region of the lumen, (d) a holding means delimitating an inner cavity, disposed adjacent to a proximal side of the stent in the sheath, the proximal end of the holding means being permanently joined to the inner shaft, and (e) a handling means placed towards the proximal side of the intraluminal apparatus, able to displace longitudinally the retracting sheath with respect to the inner shaft.

Abstract: An implantable medical device comprising (a) a metallic substrate and (b) a bisphosphonate wherein both phosphorus atoms contained in the bisphosphonate are covalently attached to a same carbon atom. The bisphosphonate continuously coats the external surface of the metallic substrate as monolayer and as outermost layer. At least one phosphonate moiety of the bisphosphonate is covalently and directly bonded to the external surface of the metallic substrate and/or covalently bonded to another molecule of the bisphosphonate in the coating.

Abstract: A medical device with metal parts to be introduced into animal or human bodies is rendered visible during RMN imaging by covering the exterior surface of the metal parts with a layer comprising Nickel monoxide. When placed within the electromagnetic field generated by a NMR apparatus, the layer reduces disturbances induced in this field in the vicinity of the metal part. This improvement is chiefly related to endoprostheses for subjects or patients who will be submitted to NMR imaging. In particular, the invention is aimed at luminal endoprostheses comprising a metal frame, as stents.

Abstract: A compound for injecting locally into an intratumoral space of a body made of a mixture of a biocompatible wax, admixed with biocompatible oil. The compound is liquid at a temperature above body temperature but compatible with the life of healthy cells. It exhibits an increasing viscosity with decreasing temperature and becomes a solid close to body temperature. The compound is then metabolized by the human body.

Abstract: A luminal endoprosthesis for treating aneurysms, particularly aneurysms located at an arterial bifurcation. One feature of the endoprosthesis is a tubular armature that can expand radially from a compressed state to an expanded state. A further feature of the endoprosthesis, when in the expanded state, is a lenticular head whom axis coincides with that of the tubular armature, and which can be inserted into an aneurysm pocket. A method of manufacturing such an endoprosthesis is also described.

Abstract: Radio-opaque endoprosthesis An endoprosthesis furnished with an armature made of metal wires visible in X-ray medical imaging in which the armature is formed of at least two layers of wires, the wires forming the armature comprising a core made of a radio-opaque material, the interaction between the cores of the wires of the various layers improving the visibility of the said endoprosthesis in X-ray medical imaging.

Abstract: Luminal endoprosthesis formed of a multi-layer braided framework. The framework is devoid of any cover layer, and formed of a plurality of stabilized layers of biocompatible metal wires which are interlaced, forming a lattice, a plurality of wires of a given layer being integrated in the lattice of the adjacent layers. The mechanical characteristics of an outermost layer is so that when in place, the layer applies against a vessel wall, the other layers extending substantially along cylindrical surfaces distinct from the outermost layer so as to form a multi-layer mat which affects the haemodynamic of a flow of blood passing along or through this mat and preventing a growing of plaque.