Abstract: Silicone oil-containing formulation for nasal application for use in a method for intranasal treatment of endogenous diseases of the nose and/or those due to exogenous causes, e.g. those which are caused by bacteria, fungi, viruses and/or allergens, wherein the silicone oil or the formulation is optionally enriched with oxygen, preferably in the presence of emulsifiers, and optionally in the presence of further active ingredients, such as ?-sympathomimetic drugs, e.g. oxymetazoline or xylometazoline, and related subjects of the invention.