Patents by Inventor Nungavaram S. Ramamurthy
Nungavaram S. Ramamurthy has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 6914057Abstract: Methods of reducing the risk of cataract development in a mammal are provided and include administering to the mammal an effective amount of a tetracycline derivative. A preferred tetracycline derivative administered according to the methods of the present invention is 6?-deoxy 5-hydroxy-4-dedimethylaminotetracycline.Type: GrantFiled: September 28, 1999Date of Patent: July 5, 2005Assignee: The Research Foundation of State University of New YorkInventors: Maria Emanuel Ryan, Lorne M. Golub, Nungavaram S. Ramamurthy
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Patent number: 6429204Abstract: The invention is a method of inhibiting a sarcoma, such as Kaposi's sarcoma, in a mammal. The method employs 6-demethyl-6-deoxy-4-de(dimethylamino)tetracycline (CMT-3.Type: GrantFiled: April 3, 2000Date of Patent: August 6, 2002Assignee: University of MiamiInventors: Lorne M. Golub, Thomas F. McNamara, Nungavaram S. Ramamurthy, Hsi-Ming Lee, Sanford Simon, Balakrishna L. Lokeshwar, Marie G. Selzer, Norman L. Block
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Patent number: 6100248Abstract: The invention is a method of inhibiting cancer growth, by inhibiting cellular proliferation, invasiveness, or metastasis, or by inducing cytotoxicity against cancer in mammals. The method employs 6-demethyl-6-deoxy-4-de(dimethylamino)tetracycline (CMT-3) and other functionally related chemically modified, preferably non-antibacterial, tetracycline compounds to inhibit cancer growth. The method is particularly effective to inhibit the establishment, growth, and metastasis of solid tumors, such as tumors derived from colon cancer cells, breast cancer cells, melanoma cells, prostatic carcinoma cells, or lung cancer cells.Type: GrantFiled: January 15, 1998Date of Patent: August 8, 2000Inventors: Lorne M. Golub, Thomas F. McNamara, Nungavaram S. Ramamurthy, Hsi-Ming Lee, Sanford Simon, Balakrishna L. Lokeshwar, Marie G. Selzer, Norman L. Block
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Patent number: 5929055Abstract: A method for treating diabetes in a mammal by moderately controlling blood glucose concentration in the mammal together with administering to the mammal an amount of a tetracycline compound effective to reduce complications associated with diabetic hyperglycemia. The method enables long term management of diabetes by avoiding the problems associated with tight control of blood glucose concentrations, i.e., hypoglycemia tolerance and seizures, while simultaneously avoiding the problems associated with conventional moderate control of blood glucose concentrations, i.e., pathological complications associated with hyperglycemia, such as nephropathy, retinopathy, etc. Blood glucose concentration can be controlled by moderate administration (e.g.Type: GrantFiled: June 23, 1997Date of Patent: July 27, 1999Assignee: The Research Foundation of State University of New YorkInventors: Maria Emanuel Ryan, Lorne M. Golub, Nungavaram S. Ramamurthy, Thomas F. McNamara
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Patent number: 5919775Abstract: The invention is a method of inhibiting the production of nitric oxide (NO) in an in vivo, in vitro, or ex vivo biological system. The method employs a tetracycline compound to inhibit the production of NO and/or to inhibit the expression or activity of an inducible isoform of nitric oxide synthase (iNOS). Preferably, the tetracycline compound has inhibitory activity for metalloproteinases. Also it is preferred that the tetracycline compound is provided to the biological system in an amount which has little or no antibacterial activity in the system. Accordingly, preferred tetracycline compounds are tetracycline compounds which have be modified to reduce or eliminate their antimicrobial activity. The method can be used to treat medical conditions in mammals characterized by NO production mediated by iNOS, including, for example, inflammatory conditions.Type: GrantFiled: April 16, 1998Date of Patent: July 6, 1999Assignees: The Research Foundation of The State University of New York, Hospital For Joint DiseasesInventors: Ashok R. Amin, Steven B. Abramson, Lorne M. Golub, Nungavaram S. Ramamurthy, Thomas F. McNamara, Robert A. Greenwald, Howard Trachtman
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Patent number: 5837696Abstract: The invention is a method of inhibiting cancer growth, including cellular proliferation, invasiveness, or metastasis in mammals. The method employs 6-demethyl-6-deoxy-4-dedimethylaminotetracycline (CMT-3) and other functionally related chemically modified, preferably non-antibacterial, tetracycline compounds to inhibit cancer growth. The method is particularly effective to inhibit the establishment, growth, and metastasis of solid tumors, such as tumors derived from colon cancer cells, breast cancer cells, melanoma cells, prostatic carcinoma cells, or lung cancer cells.Type: GrantFiled: January 15, 1997Date of Patent: November 17, 1998Assignees: The Research Foundation of State University of New York, University of MiamiInventors: Lorne M. Golub, Thomas F. McNamara, Nungavaram S. Ramamurthy, Hsi-Ming Lee, Sanford Simon, Balakrishna L. Lokeshwar, Marie G. Selzer, Norman L. Block
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Patent number: 5827840Abstract: A method for improving the healing response of epithelialized tissue (e.g., skin, mucosae) to acute traumatic injury is disclosed. The method includes employing a tetracycline compound, having substantially no antibacterial activity, to improve the capacity of the epithelialized tissue to heal acute wounds. Specifically, the method involves increasing the rate of collagen accumulation of the healing epithelialized tissue above that associated with wound healing in the individual. The method decreases proteolytic activity in the epithelialized tissue by means of the tetracycline compound, most commonly decreasing collagenolytic activity and/or decreasing gelatinolytic activity. Collagenase and gelatinase activity have been shown to be decreased by the method of the invention. Preferably, the method is employed to improve the wound healing capacity of human or animal subjects in whom such capacity is impaired. Also, the non-antibiotic tetracycline is preferably administered topically at the site of the wound.Type: GrantFiled: August 1, 1996Date of Patent: October 27, 1998Assignee: The Research Foundation of State University of New YorkInventors: Nungavaram S. Ramamurthy, Lorne M. Golub, Thomas F. McNamara
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Patent number: 5789395Abstract: A method is disclosed for inhibiting endogenous production of nitric oxide (NO) in an in vivo, in vitro, or ex vivo mammalian system. The method employs a tetracycline compound to inhibit production of NO and/or to inhibit the expression or activity of an inducible isoform of nitric oxide synthase (iNOS). Preferably, the tetracycline compound has inhibitory activity for metalloproteinases. Also it is preferred that the tetracycline compound is provided to the mammalian system in an amount which has little or no antibacterial activity in the system. Accordingly, preferred tetracycline compounds are tetracycline compounds which have be modified to reduce or eliminate their antimicrobial activity. The method can be used to treat medical conditions in mammals characterized by NO production mediated by iNOS, including, for example, inflammatory conditions.Type: GrantFiled: August 30, 1996Date of Patent: August 4, 1998Assignees: The Research Foundation of State University of New York, Hospital for Joint DiseasesInventors: Ashok R. Amin, Steven B. Abramson, Lorne M. Golub, Nungavaram S. Ramamurthy, Thomas F. McNamara, Robert A. Greenwald, Howard Trachtman
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Patent number: 5773430Abstract: A method for inhibiting the activity of serine proteinase in biological systems includes administering to the system a serine proteinase inhibitory amount of a hydrophobic 4-de(dimethylamino)tetracycline. The method reduces tissue destruction during inflammation resulting from the activity of human leukocyte elastase. The method is used for pharmaceutical and cosmetic purposes.Type: GrantFiled: March 13, 1997Date of Patent: June 30, 1998Assignee: Research Foundation of State University of New YorkInventors: Sanford R. Simon, Elizabeth J. Roemer, Lorne M. Golub, Nungavaram S. Ramamurthy
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Patent number: 4935412Abstract: Tetracyclines having substantially no effective antibiotic or antibacterial activity and possessing anti-collagen-destructive enzyme activity or anti-collagenase activity and compositions containing the same have been found useful as anti-collagenolytic agents. Such tetracyclines and compositions containing the same are useful in the treatment of periodontal diseases, corneal ulcers, bone deficiency disorders, rheumatoid arthritis diseases characterized by excessive collagen destruction. A special aspect of this invention involves the incorporation of such tetracyclines in animal feed compositions for improved animal nutrition, such as may be evidenced by increased weight gain.Type: GrantFiled: July 13, 1987Date of Patent: June 19, 1990Assignee: The Research Foundation of State University of New YorkInventors: Thomas F. McNamara, Nungavaram S. Ramamurthy, Lorne M. Golub
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Patent number: 4935411Abstract: Tetracyclines having substantially no effective antibiotic or antibacterial activity and possessing anti-collagen-destructive enzyme activity or anti-collagenase activity and compositions containing the same have been found useful as anti-collagenolytic agents. Such tetracyclines and compositions containing the same are useful in the treatment of periodontal diseases, corneal ulcers, bone deficiency disorders, rheumatoid arthritis diseases characterized by excessive collagen destruction. A special aspect of this invention involves the incorporation of such tetracyclines in animal feed compositions for improved animal nutrition, such as may be evidenced by increased weight gain.Type: GrantFiled: October 28, 1987Date of Patent: June 19, 1990Assignee: The Research Foundation of State University of New YorkInventors: Thomas F. McNamara, Nungavaram S. Ramamurthy, Lorne M. Golub
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Patent number: 4925833Abstract: Tetracyclines, antibacterial and non-antibacterial tetracyclines, have been found to be useful in the treatment of osteoporosis in humans by administering to the human suffering from osteoporosis an effective amount of a tetracycline to enhance bone protein synthesis. Tetracyclines which have been found to be effective in the treatment of osteoporosis in humans include minocycline, doxycycline and dedimethylaminotetracyline.Type: GrantFiled: December 29, 1986Date of Patent: May 15, 1990Assignee: The Research Foundation of State University of New YorkInventors: Thomas F. McNamara, Lorne M. Golub, Nungavaram S. Ramamurthy
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Patent number: 4704383Abstract: Tetracyclines having substantially no effective antibiotic or antibacterial activity and possessing anti-collagen-destructive enzyme activity or anti-collagenase activity and compositions containing the same have been found useful as anti-collagenolytic agents. Such tetracyclines and compositions containing the same are useful in the treatment of periodontal diseases, corneal ulcers, bone deficiency disorders, rheumatoid arthritis diseases characterized by excessive collagen destruction. A special aspect of this invention involves the incorporation of such tetracyclines in animal feed compositions for improved animal nutrition, such as may be evidenced by increased weight gain.Type: GrantFiled: February 7, 1985Date of Patent: November 3, 1987Assignee: The Research Foundation of State University of New YorkInventors: Thomas F. McNamara, Nungavaram S. Ramamurthy, Lorne M. Golub
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Patent number: RE34656Abstract: Tetracyclines, antibacterial and non-antibacterial tetracyclines, have been found to be useful in the treatment of osteoporosis in humans by administering to the human suffering from osteoporosis an effective amount of a tetracycline to enhance bone protein synthesis. Tetracyclines which have been found to be effective in the treatment of osteoporosis in humans include minocycline, doxycycline and dedimethylaminotetracyline.Type: GrantFiled: May 4, 1992Date of Patent: July 5, 1994Assignee: The Research Foundation of State University of New YorkInventors: Lorne M. Golub, Thomas F. McNamara, Nungavaram S. Ramamurthy