Patents by Inventor Nuno Leal

Nuno Leal has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • DOPAMINE-B-HYDROXYLASE INHIBITORS
    Publication number: 20230138795
    Abstract: This invention relates to: (a) compounds of formula Ia (with R1, R4 to R6, n and A as defined herein) and pharmaceutically acceptable salts or solvates thereof that are useful as dopamine-p-hydroxylase inhibitors; (b) pharmaceutical compositions (comprising such compounds, salts or solvates; (c) the use of such compounds, salts or solvates in therapy; (d) therapeutic methods of treatment using such compounds, salts or solvates; and (e) processes and intermediates useful for the synthesis of such compounds.
    Type: Application
    Filed: September 1, 2022
    Publication date: May 4, 2023
    Inventors: Laszlo Erno Kiss, Alexander Beliaev, Tino Rossi, Pedro Nuno Leal Palma, Patrício Manuel Vieira Araujo Soares Da Silva, Rui Pinto, Francisco Cardona
  • NITROCATECHOL DERIVATIVES AS COMT INHIBITORS
    Publication number: 20220388999
    Abstract: New compounds of formula I are described: The compounds have potentially valuable pharmaceutical properties in the treatment of some central and peripheral nervous system disorders.
    Type: Application
    Filed: March 15, 2022
    Publication date: December 8, 2022
    Inventors: David Alexander Learmonth, Laszlo Erno Kiss, Pedro Nuno Leal Palma, Humberto dos Santos Ferreira, Patrício Manuel Vieira Araujo Soares Da Silva
  • Dopamine-b-hydroxylase inhibitors
    Patent number: 11434242
    Abstract: This invention relates to: (a) compounds of formula Ia (with R1, R4 to R6, n and A as defined herein) and pharmaceutically acceptable salts or solvates thereof that are useful as dopamine-?-hydroxylase inhibitors; (b) pharmaceutical compositions (comprising such compounds, salts or solvates; (c) the use of such compounds, salts or solvates in therapy; (d) therapeutic methods of treatment using such compounds, salts or solvates; and (e) processes and intermediates useful for the synthesis of such compounds.
    Type: Grant
    Filed: November 30, 2018
    Date of Patent: September 6, 2022
    Assignee: BIAL—PORTELA & CA, S.A.
    Inventors: Laszlo Erno Kiss, Alexander Beliaev, Tino Rossi, Pedro Nuno Leal Palma, Patrício Manuel Vieira Araujo Soares Da Silva, Rui Pinto, Francisco Cardona
  • BLOOD-BRAIN BARRIER-PENETRANT DOPAMINE-ß-HYDROXYLASE INHIBITORS
    Publication number: 20220017523
    Abstract: This invention relates to: (a) compounds of formula I (with R1 to R5, n and A as defined herein) and pharmaceutically acceptable salts or solvates thereof that are useful as dopamine-?-hydroxylase inhibitors; (b) pharmaceutical compositions comprising such compounds, salts or solvates; (c) the use of such compounds, salts or solvates in therapy; (d) therapeutic methods of treatment using such compounds, salts or solvates; and (e) processes and intermediates useful for the synthesis of such compounds.
    Type: Application
    Filed: March 11, 2021
    Publication date: January 20, 2022
    Inventors: Patrício Soares Da Silva, Tino Rossi, Laszlo Erno Kiss, Alexander Beliaev, Pedro Nuno Leal Palma
  • Seal housing for an electrical device and sealed relay using the seal housing
    Patent number: 11094489
    Abstract: A seal housing for an electrical device comprises a base, a cover adapted to cover an inwardly facing side of the base to form a closed chamber for accommodating components of the electrical device, and a sealing plate adapted to partially cover an outwardly facing side of the base. The sealing plate has an outward side with a profile that is shaped to divert fluid or fluid condensate formed at the outward side of the sealing plate.
    Type: Grant
    Filed: September 28, 2018
    Date of Patent: August 17, 2021
    Assignee: Tyco Electronics Componentes Electromecanicos Lda.
    Inventors: Louis Sandoval, Nuno Leal
  • Dopamine-?-hydroxylase inhibitors
    Patent number: 11034695
    Abstract: This invention relates to: (a) compounds of Formula Ia (with R1, R4, R5, R6, n and A as defined herein) and pharmaceutically acceptable salts or solvates thereof that are useful as dopamine-?-hydroxylase inhibitors; (b) pharmaceutical compositions comprising such compounds, salts or solvates; (c) the use of such compounds, salts or solvates in therapy; (d) therapeutic methods of treatment using such compounds, salts or solvates; and (e) processes and intermediates useful for the synthesis of such compounds.
    Type: Grant
    Filed: September 22, 2017
    Date of Patent: June 15, 2021
    Assignee: BIAL—PORTELA & Cᵃ, S.A.
    Inventors: Patrício Soares Da Silva, Tino Rossi, Laszlo Erno Kiss, Alexander Beliaev, Pedro Nuno Leal Palma
  • DOPAMINE-B-HYDROXYLASE INHIBITORS
    Publication number: 20210171528
    Abstract: This invention relates to: (a) compounds of formula Ia (with R1, R4 to R6, n and A as defined herein) and pharmaceutically acceptable salts or solvates thereof that are useful as dopamine-?-hydroxylase inhibitors; (b) pharmaceutical compositions (comprising such compounds, salts or solvates; (c) the use of such compounds, salts or solvates in therapy; (d) therapeutic methods of treatment using such compounds, salts or solvates; and (e) processes and intermediates useful for the synthesis of such compounds.
    Type: Application
    Filed: November 30, 2018
    Publication date: June 10, 2021
    Inventors: Laszlo Erno Kiss, Alexander Beliaev, Tino Rossi, Pedro Nuno Leal Palma, Patrício Manuel Vieira Araujo Soares Da Silva, Rui Pinto, Francisco Cardona
  • Blood-brain barrier-penetrant dopamine-?-hydroxylase inhibitors
    Patent number: 10975083
    Abstract: This invention relates to: (a) compounds of formula (I) (with R1 to R5, n and A as defined herein) and pharmaceutically acceptable salts or solvates thereof that are useful as dopamine-?-hydroxylase inhibitors; (b) pharmaceutical compositions comprising such compounds, salts or solvates; (c) the use of such compounds, salts or solvates in therapy; (d) therapeutic methods of treatment using such compounds, salts or solvates; and (e) processes and intermediates useful for the synthesis of such compounds.
    Type: Grant
    Filed: September 22, 2017
    Date of Patent: April 13, 2021
    Assignee: BIAL—PORTELA & CA, S.A.
    Inventors: Patrício Soares Da Silva, Tino Rossi, Laszlo Erno Kiss, Alexander Beliaev, Pedro Nuno Leal Palma
  • DOPAMINE-B-HYDROXYLASE INHIBITORS
    Publication number: 20200181148
    Abstract: This invention relates to: (a) compounds of Formula Ia (with R1, R4, R5, R6, n and A as defined herein) and pharmaceutically acceptable salts or solvates thereof that are useful as dopamine-?-hydroxylase inhibitors; (b) pharmaceutical compositions comprising such compounds, salts or solvates; (c) the use of such compounds, salts or solvates in therapy; (d) therapeutic methods of treatment using such compounds, salts or solvates; and (e) processes and intermediates useful for the synthesis of such compounds.
    Type: Application
    Filed: September 22, 2017
    Publication date: June 11, 2020
    Inventors: Patrício Soares Da Silva, Tino Rossi, Laszlo Erno Kiss, Alexander Beliaev, Pedro Nuno Leal Palma
  • NITROCATECHOL DERIVATIVES AS COMT INHIBITORS
    Publication number: 20200102295
    Abstract: New compounds of formula I are described: The compounds have potentially valuable pharmaceutical properties in the treatment of some central and peripheral nervous system disorders.
    Type: Application
    Filed: June 26, 2019
    Publication date: April 2, 2020
    Inventors: David Alexander Learmonth, Laszlo Erno Kiss, Pedro Nuno Leal Palma, Humberto dos Santos Ferreira, Patricio Manuel V. A. Soares Da Silva
  • BLOOD-BRAIN BARRIER-PENETRANT DOPAMINE-B-HYDROXYLASE INHIBITORS
    Publication number: 20190337950
    Abstract: This invention relates to: (a) compounds of formula (I) (with R1 to R5, n and A as defined herein) and pharmaceutically acceptable salts or solvates thereof that are useful as dopamine-?-hydroxylase inhibitors; (b) pharmaceutical compositions comprising such compounds, salts or solvates; (c) the use of such compounds, salts or solvates in therapy; (d) therapeutic methods of treatment using such compounds, salts or solvates; and (e) processes and intermediates useful for the synthesis of such compounds.
    Type: Application
    Filed: September 22, 2017
    Publication date: November 7, 2019
    Inventors: Patrício Soares Da Silva, Tino Rossi, Laszlo Erno Kiss, Alexander Beliaev, Pedro Nuno Leal Palma
  • Nitrocatechol derivatives as COMT inhibitors
    Patent number: 10336740
    Abstract: New compounds of formula I are described. The compounds have potentially valuable pharmaceutical properties in the treatment of some central and peripheral nervous system disorders.
    Type: Grant
    Filed: January 10, 2017
    Date of Patent: July 2, 2019
    Assignee: BIAL—PORTELA & CA, S.A.
    Inventors: David Alexander Learmonth, Laszlo Erno Kiss, Pedro Nuno Leal Palma, Humberto dos Santos Ferreira, Patricio Manuel V. A. Soares Da Silva
  • ADMINISTRATION REGIME FOR NITROCATECHOLS
    Publication number: 20190144436
    Abstract: A compound of formula (I) where R1, R2, X, Y, n, m, R3, R4, R5, R6 and R7 are as defined herein, for use in the prophylaxis or treatment of a central and peripheral nervous system disorder, wherein the compound of formula (I) is administered prior to sleep, before bedtime or at bedtime.
    Type: Application
    Filed: August 28, 2018
    Publication date: May 16, 2019
    Inventors: Patricio Manuel Vieira Araujo Soares Da Silva, Teresa Lucia Silva Pereira Nunes, Lyndon Christopher Wright, Pedro Nuno Leal Palma, David Alexander Learmonth
  • Seal Housing For An Electrical Device and Sealed Relay Using The Seal Housing
    Publication number: 20190103239
    Abstract: A seal housing for an electrical device comprises a base, a cover adapted to cover an inwardly facing side of the base to form a closed chamber for accommodating components of the electrical device, and a sealing plate adapted to partially cover an outwardly facing side of the base. The sealing plate has an outward side with a profile that is shaped to divert fluid or fluid condensate formed at the outward side of the sealing plate.
    Type: Application
    Filed: September 28, 2018
    Publication date: April 4, 2019
    Applicant: Tyco Electronics Componentes Electromecanicos Lda.
    Inventors: Louis Sandoval, Nuno Leal
  • Administration regime for nitrocatechols
    Patent number: 10065944
    Abstract: A compound of formula (I) where R1, R2, X, Y, n, m, R3, R4, R5, R6 and R7 are as defined herein, for use in the prophylaxis or treatment of a central and peripheral nervous system disorder, wherein the compound of formula (I) is administered prior to sleep, before bedtime or at bedtime.
    Type: Grant
    Filed: August 9, 2013
    Date of Patent: September 4, 2018
    Assignee: BIAL-PORTELA & CA, S.A.
    Inventors: Patricio Manuel Vieira Araujo Soares Da Silva, Teresa Lucia Silva Pereira Nunes, Lyndon Christopher Wright, Pedro Nuno Leal Palma, David Alexander Learmonth
  • NITROCATECHOL DERIVATIVES AS COMT INHIBITORS
    Publication number: 20170362213
    Abstract: New compounds of formula I are described. The compounds have potentially valuable pharmaceutical properties in the treatment of some central and peripheral nervous system disorders.
    Type: Application
    Filed: January 10, 2017
    Publication date: December 21, 2017
    Inventors: David Alexander Learmonth, Laszlo Erno Kiss, Pedro Nuno Leal Palma, Humberto dos Santos Ferreira, Patricio Manuel V. A. Soares Da Silva
  • Dosage regimen for COMT inhibitors
    Patent number: 9745290
    Abstract: The invention relates to the use of an oxodiazolyl compound (I) for the preparation of a medicament for the prevention or treatment of central and peripheral nervous system associated disorders, wherein said medicament is administered according to a dosing regimen having a dosing periodicity ranging from about twice a day to about once every other day.
    Type: Grant
    Filed: April 17, 2015
    Date of Patent: August 29, 2017
    Assignee: BIAL—PORTELA & CA, S.A.
    Inventors: David Alexander Learmonth, Laszlo Erno Kiss, Pedro Nuno Leal Palma, Humberto dos Santos Ferreira, Patricio Manuel V. A. Soares da Silva
  • Nitrocatechol derivatives as COMT inhibitors
    Patent number: 9550759
    Abstract: New compounds of formula I are described. The compounds have potentially valuable pharmaceutical properties in the treatment of some central and peripheral nervous system disorders.
    Type: Grant
    Filed: November 14, 2014
    Date of Patent: January 24, 2017
    Assignee: BIAL—PORTELA & CA, S.A.
    Inventors: David Alexander Learmonth, Laszlo Erno Kiss, Pedro Nuno Leal Palma, Humberto Dos Santos Ferreira, Patricio Manuel Vieira Araujo Soares Da Silva
  • Pharmaceutical compounds
    Patent number: 9446012
    Abstract: This invention relates to novel substituted nitrocatechol derivatives, their use in the treatment of some central and peripheral nervous system disorders and pharmaceutical compositions containing them.
    Type: Grant
    Filed: August 30, 2013
    Date of Patent: September 20, 2016
    Assignee: BIAL—PORTELA & CA, S.A.
    Inventors: David Alexander Learmonth, Laszlo Erno Kiss, Pedro Nuno Leal Palma, Humberto dos Santos Ferreira, Patricio Manuel V. A. Soares da Silva
  • Pharmaceutical compounds
    Patent number: 9353082
    Abstract: The invention relates to compounds and compositions for inhibiting the enzyme fatty acid amide hydrolase (FAAH), the use of the compounds in therapy and, in particular, for treating or preventing conditions whose development or symptoms are linked to substrates of the FAAH enzyme, and methods of treatment or prevention using the compounds and compositions.
    Type: Grant
    Filed: December 23, 2009
    Date of Patent: May 31, 2016
    Assignee: BIAL—PORTELA & CA, S.A.
    Inventors: Laszlo Erno Kiss, David Alexander Learmonth, Carla Patrícia da Costa Pereira Rosa, Rita Gusmãmo de Noronha, Pedro Nuno Leal Palma, Patrício Manuel Vieira Araújo Soares da Silva, Alexander Beliaev