Abstract: A dental prosthesis formed of a composition comprising a polymeric material, the prosthesis comprising one or more locating formations adapted to receive a dental implant fixture or dental abutment, the or each locating formation comprising a recess comprising a first recess portion formed in the polymeric material of the prosthesis, and a second recess portion provided in a sleeve located in the prosthesis.

Abstract: A dental prosthesis formed of a composition comprising a polymeric material, the prosthesis comprising one or more locating formations adapted to receive a dental implant fixture or dental abutment, the or each locating formation comprising a recess comprising a first recess portion formed in the polymeric material of the prosthesis, and a second recess portion provided in a sleeve located in the prosthesis.

Abstract: A dental implant comprises a composition which comprises a polymeric material which is preferably polyetheretherketone, and an apatite, for example a hydroxy-containing apatite. A prosthodontics device may comprise a dental implant made from polyetheretherketone, an abutment, also made from PEEK, and a crown, which is also made from PEEK by machining from a PEEK disc.

Abstract: A method for forming an integrated or repaired dental framework is disclosed. Portions of dental framework formed of a polymeric material are provided with a male member on a joint surface of one portion and a female member on a joint surfaces of second portion, with the male and female members arranged to mate together to hold the portions together at the joint surfaces and then welded together by ultrasonic welding. Integrated dental frameworks formed by the method using sequential moulding of portions of a patient's mouth are also disclosed. Apparatus and methods for forming a dental prosthetic item such as a portion of such a framework, or a repair piece, by injecting a flowable thermoplastic composition into a mould under pressure, are also disclosed.

Abstract: A method of making a prosthetic dental item comprises selecting a block having a square or rectangular cross-section along is extent, wherein said block comprises polyetheretherketone and, optionally, an apatite, wherein said polymeric material has a crystallinity of at least 25%. The method comprises machining the block in dependence upon data collated using digital technology. Since the crystallinity of the material selected is high, a post-machining step whereby crystallinity is increased can be avoided, and dental items of high precision can be formed.

Abstract: A framework for a removable, partial or complete prosthodontic device is made by machining, using a CAD/CAM technique, a disc 2, made from polyetheretherketone, to define the framework 4. Prosthetic teeth and gums can be secured to the framework to define the prosthodontic device.

Abstract: A dental implant comprises a composition which comprises a polymeric material which is preferably polyetheretherketone, and an apatite, for example a hydroxy-containing apatite. A prosthodontics device may comprise a dental implant made from polyetheretherketone, an abutment, also made from PEEK, and a crown, which is also made from PEEK by machining from a PEEK disc.

Abstract: The invention involves therapy and diagnostics using nanoparticles that provide targeted delivery of agents to cancer cells and stem cells, including cancer stem cells, the nanoparticles being pH sensitive and incorporating cytotoxic ceramides.

Abstract: A framework for a removable, partial or complete prosthodontic device is made by machining, using a CAD/CAM technique, a disc 2, made from polyetheretherketone, to define the framework 4. Prosthetic teeth and gums can be secured to the framework to define the prosthodontic device.

Abstract: Topographical features, such as projections or recesses, having a maximum dimension which is less than 3 ?m, with the features being separated by a distance which is less than 10 ?m are transferred to polyetheretherketone, on an industrial scale, by injection moulding relatively low viscosity PEEK, using a mould in which is arranged a master structure which carries the desired topography. The topographical features increase the water contact angle of a surface which includes them and such a modified surface has been shown to influence cell attachment and differentiation. Parts which incorporate the topographical features may be used in medical devices such as implantable medical devices for cardiology or for neuromodulation.

Abstract: The present invention provides a system presenting site-specific accumulation through a ligand that specifically targets a receptor overexpressed on the surface of specific cells within a target organ, like, for example, tumor cells and/or vascular cells of tumor blood vessels. Moreover, this invention provides a method where, upon internalization of the previous-mentioned system by the target cells, triggered release at a high rate of the associated agent takes place, permitting efficient intracellular delivery and, thus, increased concentration of the transported cargo at the target site. Overall, this invention provides a method for the diagnosis, prevention and treatment of human diseases and disorders.

Abstract: The present invention provides a system presenting site-specific accumulation through a ligand that specifically targets a receptor overexpressed on the surface of specific cells within a target organ, like, for example, tumor cells and/or vascular cells of tumor blood vessels. Moreover, this invention provides a method where, upon internalization of the previous-mentioned system by the target cells, triggered release at a high rate of the associated agent takes place, permitting efficient intracellular delivery and, thus, increased concentration of the transported cargo at the target site. Overall, this invention provides a method for the diagnosis, prevention and treatment of human diseases and disorders.

Abstract: The present invention provides a system presenting site-specific accumulation through a ligand that specifically targets a receptor overexpressed on the surface of specific cells within a target organ, like, for example, tumor cells and/or vascular cells of tumor blood vessels. Moreover, this invention provides a method where, upon internalization of the previous-mentioned system by the target cells, triggered release at a high rate of the associated agent takes place, permitting efficient intracellular delivery and, thus, increased concentration of the transported cargo at the target site. Overall, this invention provides a method for the diagnosis, prevention and treatment of human diseases and disorders.

Abstract: A titanium body (2) of a femoral nail incorporates an opening (3) leading into a hollow region (4) which defines a cavity in which electronics may be incorporated. A potting compound overlays the electronics, within the region (4). A 100 to 150 ?m thick cover (18) made from polyetheretherketone is arranged to overlay the opening (3) and close the hollow region (4). The cover (18) is made from flat polyetheretherketone film of suitable thickness which is heat shrunk onto a former and then machined to define the desired shape.

Abstract: The present invention provides a system presenting site-specific accumulation through a ligand that specifically targets a receptor overexpressed on the surface of specific cells within a target organ, like, for example, tumor cells and/or vascular cells of tumor blood vessels. Moreover, this invention provides a method where, upon internalization of the previous-mentioned system by the target cells, triggered release at a high rate of the associated agent takes place, permitting efficient intracellular delivery and, thus, increased concentration of the transported cargo at the target site. Overall, this invention provides a method for the diagnosis, prevention and treatment of human diseases and disorders.

Abstract: An enclosure of an active implantable device comprises a composite material which comprises a first layer of a polyetheretherketone film, a second layer of polyetheretherketone film (8) and, sandwiched between, a third layer comprising titanium. The arrangement may be provided in various embodiments such as comprising housing halves (70,72) and a lid (74), each being made of the three layers described. In one embodiment, a communications window may be provided which has a thinner layer of titanium, to facilitate communications between the outside and electrical components positioned within the enclosure.

Abstract: The present invention provides a system presenting site-specific accumulation through a ligand that specifically targets a receptor overexpressed on the surface of specific cells within a target organ, like, for example, tumor cells and/or vascular cells of tumor blood vessels. Moreover, this invention provides a method where, upon internalization of the previous-mentioned system by the target cells, triggered release at a high rate of the associated agent takes place, permitting efficient intracellular delivery and, thus, increased concentration of the transported cargo at the target site. Overall, this invention provides a method for the diagnosis, prevention and treatment of human diseases and disorders.

Abstract: The present invention provides a system presenting site-specific accumulation through a ligand that specifically targets a receptor overexpressed on the surface of specific cells within a target organ, like, for example, tumor cells and/or vascular cells of tumor blood vessels. Moreover, this invention provides a method where, upon internalization of the previous-mentioned system by the target cells, triggered release at a high rate of the associated agent takes place, permitting efficient intracellular delivery and, thus, increased concentration of the transported cargo at the target site. Overall, this invention provides a method for the diagnosis, prevention and treatment of human diseases and disorders.