Patents by Inventor Nunzio Bottini

Nunzio Bottini has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • IMMUNOREGULATORY MICROPARTICLES FOR MODULATING INFLAMMATORY ARTHRITIDES
    Publication number: 20240033242
    Abstract: Described herein are compositions and methods for treating inflammatory arthritic conditions tint are effective systemically without causing generalized immunosuppression when administered locally into an inflammatory arthritis-affected joint or a draining lymph node of the arthritis-affected joint of a patient.
    Type: Application
    Filed: September 25, 2023
    Publication date: February 1, 2024
    Inventors: Nisarg Shah, David A. McBride, Nunzio Bottini
  • PTPRS AND PROTEOGLYCANS IN AUTOIMMUNE DISEASE
    Publication number: 20220325261
    Abstract: Provided herein, inter alia, are PTPRS de-clustering agents and compositions and kits comprising the agents. Provided are methods of modulating extracellular matrix or decreasing fibroblast activity in a subject. Also provided are methods of treating subjects with or at risk of developing extracellular matrix diseases, fibroblast-mediated diseases, or autoimmune diseases.
    Type: Application
    Filed: June 23, 2022
    Publication date: October 13, 2022
    Inventors: Nunzio Bottini, Stephanie Stanford
  • PTP4A1 as a therapeutic target for fibrotic diseases and disorders including systemic sclerosis
    Patent number: 11331388
    Abstract: Methods of treating fibrotic diseases and disorders including Systemic sclerosis (SSc) are provided. Methods include, for example, administering to a subject an effective amount of an antagonist/inhibitor of PTP4A1 protein expression or activity to treat a fibrotic disease or disorder such as SSc, or an associated pathology such as organ or skin fibrosis.
    Type: Grant
    Filed: September 6, 2016
    Date of Patent: May 17, 2022
    Assignee: LA JOLLA INSTITUTE FOR ALLERGY AND IMMUNOLOGY
    Inventors: Nunzio Bottini, Cristiano Sacchetti, Stephanie M. Stanford
  • Inhibitors of low molecular weight protein tyrosine phosphatase and uses thereof
    Patent number: 11220486
    Abstract: Herein are provided, inter alia, compounds capable of modulating the level of activity of low molecular weight protein tyrosine phosphatase (LMPTP) and methods of using the same. In embodiments, the compound has a structure according to Formula (I-A).
    Type: Grant
    Filed: February 18, 2020
    Date of Patent: January 11, 2022
    Assignees: LA JOLLA INSTITUTE OF ALLERGY & IMMUNOLOGY, SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE
    Inventors: Nunzio Bottini, Jiwen Zou, Santhi R. Ganji, Stephanie Stanford, Anthony Pinkerton, Thomas D. Y. Chung, Michael Hedrick, Robert Ardecky
  • PTPRS AND PROTEOGLYCANS IN RHEUMATOID ARTHRITIS
    Publication number: 20210393740
    Abstract: Provided herein, inter alia, are pharmaceutical compositions methods thereof that include a first amount of a PTPRS de-clustering agent and a second amount of a TNF inhibitor or an IL-6 inhibitor in synergistic amounts. The synergistic combinations provide (a) amelioration of disease or one or more symptoms of disease or (b) delay of onset of disease or one or more symptoms of disease.
    Type: Application
    Filed: September 19, 2019
    Publication date: December 23, 2021
    Inventor: Nunzio Bottini
  • Inhibitors of Low Molecular Weight Protein Tyrosine Phosphatase and Uses Thereof
    Publication number: 20200290977
    Abstract: Herein are provided, inter alia, compounds capable of modulating the level of activity of low molecular weight protein tyrosine phosphatase (LMPTP) and methods of using the same. In embodiments, the compound has a structure according to Formula (I-A).
    Type: Application
    Filed: February 18, 2020
    Publication date: September 17, 2020
    Inventors: Nunzio BOTTINI, Jiwen ZOU, Santhi R. GANJI, Stephanie STANFORD, Anthony PINKERTON, Thomas D. Y. CHUNG, Michael HEDRICK, Robert ARDECKY
  • PROTEOGLYCAN IRREGULARITIES IN ABNORMAL FIBROBLASTS AND THERAPIES BASED THEREFROM
    Publication number: 20200132673
    Abstract: Provided herein are methods to identify agents or compounds that specifically modulate the oligomerization and/or functional activities of receptor protein tyrosine phosphatase sigma (RPTP?) in an abnormal fibroblast cell and therapies based therefrom.
    Type: Application
    Filed: March 24, 2018
    Publication date: April 30, 2020
    Inventors: Nunzio Bottini, Eugenio Santelli, Christian Secchi
  • Inhibitors of low molecular weight protein tyrosine phosphatase and uses thereof
    Patent number: 10626094
    Abstract: Herein are provided, inter alia, compounds capable of modulating the level of activity of low molecular weight protein tyrosine phosphatase (LMPTP) and methods of using the same. In embodiments, the compound has a structure according to Formula (I-A).
    Type: Grant
    Filed: October 14, 2015
    Date of Patent: April 21, 2020
    Assignees: SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE, LA JOLLA INSTITUTE OF ALLERGY & IMMUNOLOGY
    Inventors: Nunzio Bottini, Jiwen Zou, Santhi R. Ganji, Stephanie Stanford, Anthony Pinkerton, Thomas D. Y. Chung, Michael Hedrick, Robert Ardecky
  • Modulation of PTPRA to treat arthritis
    Patent number: 10604585
    Abstract: Presented is a method for treating inflammation and autoimmune diseases through the use of a phosphatase rheumatoid arthritis (PT-PRA) antagonist.
    Type: Grant
    Filed: September 9, 2015
    Date of Patent: March 31, 2020
    Assignees: La Jolla Institute for Allergy & Immunology, The Regents of the University of California
    Inventors: Nunzio Bottini, Gary Firestein, Stephanie Stanford
  • Autoimmune disease treatments
    Patent number: 10385340
    Abstract: There are provided, inter alia, methods and compositions to treat autoimmune disease including invasiveness of fibroblast-like synoviocytes in rheumatoid arthritis.
    Type: Grant
    Filed: November 10, 2015
    Date of Patent: August 20, 2019
    Assignee: LA JOLLA INSTITUTE FOR ALLERGY AND IMMUNOLOGY
    Inventors: Nunzio Bottini, Stephanie Stanford
  • Inhibitors of Low Molecular Weight Protein Tyrosine Phosphatase and Uses Thereof
    Publication number: 20170247340
    Abstract: Herein are provided, inter alia, compounds capable of modulating the level of activity of low molecular weight protein tyrosine phosphatase (LMPTP) and methods of using the same. In embodiments, the compound has a structure according to Formula (I-A).
    Type: Application
    Filed: October 14, 2015
    Publication date: August 31, 2017
    Inventors: Nunzio BOTTINI, Jiwen ZOU, Santhi R. GANJI, Stephanie STANFORD, Anthony PINKERTON, Thomas CHUNG, Michael HEDRICK, Robert ARDECKY
  • MODULATION OF PTPRA TO TREAT ARTHRITIS
    Publication number: 20170247469
    Abstract: Presented is a method for treating inflammation and autoimmune diseases through the use of a phosphatase rheumatoid arthritis (PT-PRA) antagonist.
    Type: Application
    Filed: September 9, 2015
    Publication date: August 31, 2017
    Inventors: Nunzio Bottini, Gary Firestein, Stephanie Stanford
  • AUTOIMMUNE DISEASE TREATMENTS
    Publication number: 20160122768
    Abstract: There are provided, inter alia, methods and compositions to treat autoimmune disease including invasiveness of fibroblast-like synoviocytes in rheumatoid arthritis.
    Type: Application
    Filed: November 10, 2015
    Publication date: May 5, 2016
    Inventors: Nunzio Bottini, Stephanie Stanford
  • PTPRS AND PROTEOGLYCANS IN AUTOIMMUNE DISEASE
    Publication number: 20150175979
    Abstract: Provided herein, inter alia, are PTPRS de-clustering agents and compositions and kits comprising the agents. Provided are methods of modulating extracellular matrix or decreasing fibroblast activity in a subject. Also provided are methods of treating subjects with or at risk of developing extracellular matrix diseases, fibroblast-mediated diseases, or autoimmune diseases.
    Type: Application
    Filed: July 23, 2013
    Publication date: June 25, 2015
    Inventors: Nunzio Bottini, Stephanie Stanford
  • COMPOSITIONS AND METHODS OF MODULATING RECEPTOR PROTEIN TYROSINE PHOSPHATASES
    Publication number: 20130171164
    Abstract: Provided herein, inter alia, are compositions and methods of measuring levels of RPTP protein and RNA and treating subjects with certain diseases, such as autimmune diseases.
    Type: Application
    Filed: August 2, 2012
    Publication date: July 4, 2013
    Applicant: LA JOLLA INSTITUTE FOR ALLERGY & IMMUNOLOGY
    Inventors: Nunzio Bottini, Stephanie Stanford
  • Method for monitoring intracellular tyrosine phosphatase activity
    Patent number: 8399213
    Abstract: The invention relates in general to tyrosine dephosphorylation. More specifically, the invention relates to methods and compositions for monitoring intracellular tyrosine dephosphorylation at the single cell level. The invention further relates to techniques that can be used as aid in the development of novel therapeutics, and monitor regulation of intracellular tyrosine phosphatase activity at the single cell level.
    Type: Grant
    Filed: September 30, 2009
    Date of Patent: March 19, 2013
    Assignee: University of Southern California
    Inventors: Nunzio Bottini, Stephanie Stanford, Amy Barrios, Sayantan Mitra
  • Methods and compositions for acid phosphatase-1 gene inhibition
    Patent number: 8034794
    Abstract: The ACP1 *A allele provides a means for diagnosing susceptibility of a human subject to hyperlipidemia, especially hyperlipidemia associated with metabolic syndrome, a means for treating, or preventing the onset of, hyperlipidemia and metabolic syndrome, and a means for screening and identifying drugs suitable for use in treating or preventing hyperlipidemia, especially hyperlipidemia associated with metabolic syndrome. Diagnostic kits are also provided.
    Type: Grant
    Filed: July 13, 2010
    Date of Patent: October 11, 2011
    Inventors: David E. Comings, James P. MacMurray, Nunzio Bottini
  • Methods and compositions for acid phosphatase-1 gene inhibition
    Publication number: 20100280103
    Abstract: The ACP1 *A allele provides a means for diagnosing susceptibility of a human subject to hyperlipidemia, especially hyperlipidemia associated with metabolic syndrome, a means for treating, or preventing the onset of, hyperlipidemia and metabolic syndrome, and a means for screening and identifying drugs suitable for use in treating or preventing hyperlipidemia, especially hyperlipidemia associated with metabolic syndrome. Diagnostic kits are also provided.
    Type: Application
    Filed: July 13, 2010
    Publication date: November 4, 2010
    Inventors: David E. Comings, James P. MacMurray, Nunzio Bottini
  • SMALL MOLECULE INHIBITORS OF LYMPHOID TYROSINE PHOSPHATASE
    Publication number: 20100210836
    Abstract: The present invention relates to lymphoid tyrosine phosphatase inhibitors and autoimmunity. More specifically, the invention relates to the identification of lymphoid tyrosine phosphatase inhibitors and the analysis of the structure-activity relationship.
    Type: Application
    Filed: February 12, 2010
    Publication date: August 19, 2010
    Applicant: University of Southern California
    Inventors: Nunzio BOTTINI, Nouri Neamati
  • METHOD FOR MONITORING INTRACELLULAR TYROSINE PHOSPHATASE ACTIVITY
    Publication number: 20100086957
    Abstract: The invention relates in general to tyrosine dephosphorylation. More specifically, the invention relates to methods and compositions for monitoring intracellular tyrosine dephosphorylation at the single cell level. The invention further relates to techniques that can be used as aid in the development of novel therapeutics, and monitor regulation of intracellular tyrosine phosphatase activity at the single cell level.
    Type: Application
    Filed: September 30, 2009
    Publication date: April 8, 2010
    Applicant: University of Southern California
    Inventors: Nunzio BOTTINI, Stephanie Stanford, Amy Barrios, Sayantan Mitra