Patents by Inventor Nutan Prasain

Nutan Prasain has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11739293
    Abstract: The present disclosure relates generally to methods and compositions useful in cell and tissue biology and therapeutics. In particular, an in vitro method for differentiating pluripotent stem cells into KDR+NCAM+APLNR+ mesoderm cells and/or SSEA5?KDR+NCAM+APLNR+ mesoderm cells is provided. The disclosed mesoderm cells may be used to generate blood vessels in vivo and/or further differentiated in vitro into endothelial colony forming cell-like cells (ECFC-like cells). Purified human cell populations of KDR+NCAM+APLNR+ mesoderm cells and ECFC-like cells are provided. Test agent screening and therapeutic methods for using the cell populations of the present disclosure are provided.
    Type: Grant
    Filed: August 4, 2017
    Date of Patent: August 29, 2023
    Assignee: Indiana University Research and Technology Corporation
    Inventors: Mervin C. Yoder, Nutan Prasain
  • Publication number: 20230174929
    Abstract: The present disclosure relates generally to methods and compositions useful in cell and tissue biology and therapeutics. In particular, an in vitro method for differentiating pluripotent stem cells into KDR+NCAM+APLNR+ mesoderm cells and/or SSEA5?KDR+NCAM+APLNR+ mesoderm cells is provided. The disclosed mesoderm cells may be used to generate blood vessels in vivo and/or further differentiated in vitro into endothelial colony forming cell-like cells (ECFC-like cells). Purified human cell populations of KDR+NCAM+APLNR+ mesoderm cells and ECFC-like cells are provided. Test agent screening and therapeutic methods for using the cell populations of the present disclosure are provided.
    Type: Application
    Filed: January 26, 2023
    Publication date: June 8, 2023
    Inventors: Mervin C. Yoder, Nutan Prasain
  • Publication number: 20220288131
    Abstract: The present invention generally relates to novel mesoderm-derived vascular progenitor cells (meso-VPCs) and methods of producing the meso-VPCs. The present invention also relates to methods of treating a vascular disease, such as critical limb ischemia, by administering the meso-VPCs into a subject.
    Type: Application
    Filed: August 27, 2020
    Publication date: September 15, 2022
    Inventors: Maria Mirotsou, Nutan Prasain, Amrita Singh, Robert Lanza
  • Publication number: 20220280572
    Abstract: The present invention provides methods for treating vascular diseases with hemogenic endothelial cells (HEs) obtained in vitro from pluripotent stem cells. The present invention also provides compositions and methods of producing the HEs.
    Type: Application
    Filed: August 27, 2020
    Publication date: September 8, 2022
    Inventors: Nagisa Sakurai, Maria Mirotsou, Nutan Prasain, Amrita Singh, Robert Lanza
  • Publication number: 20200095557
    Abstract: Co-culture of isolated human induced pluripotent stem cell (iPSC)-derived endothelial and smooth-muscle progenitor cells results in the formation of cellular spheroids having capillary-like structures (referred to herein as ‘capillary fragments’) at their core. Bioprinting of these spheroids into scaffold-free tissue constructs facilitates the development of microvasculature within the engineered tissue. Methods of using these bioprinted engineered tissues for cell therapy are also disclosed.
    Type: Application
    Filed: September 24, 2019
    Publication date: March 26, 2020
    Applicant: Indiana University Research and Technology Corporation
    Inventors: Nicanor I. Moldovan, Mervin C. Yoder, Nutan Prasain
  • Patent number: 10563175
    Abstract: The present disclosure relates generally to methods and compositions useful in cell and tissue biology and therapeutics. In particular, an in vitro method for differentiating pluripotent cells into endothelial colony forming cell-like cells (ECFC-like cells) is provided. A purified human cell population of NRP-1+CD31+ ECFC-like cells is provided, wherein at least some of the cells in the population have a high proliferation potential. Therapeutic and test agent screening methods for using the cell populations of the present disclosure are provided.
    Type: Grant
    Filed: March 11, 2015
    Date of Patent: February 18, 2020
    Assignee: Indiana University Research and Technology Corporation
    Inventors: Mervin Yoder, Nutan Prasain
  • Publication number: 20190211304
    Abstract: The present disclosure relates generally to methods and compositions useful in cell and tissue biology and therapeutics. In particular, an in vitro method for differentiating pluripotent stem cells into KDR+NCAM+APLNR+ mesoderm cells and/or SSEA5?KDR+NCAM+APLNR+ mesoderm cells is provided. The disclosed mesoderm cells may be used to generate blood vessels in vivo and/or further differentiated in vitro into endothelial colony forming cell-like cells (ECFC-like cells). Purified human cell populations of KDR+NCAM+APLNR+mesoderm cells and ECFC-like cells are provided. Test agent screening and therapeutic methods for using the cell populations of the present disclosure are provided.
    Type: Application
    Filed: August 4, 2017
    Publication date: July 11, 2019
    Applicant: Indiana University Research and Technology Corporation
    Inventors: Mervin C. Yoder, Nutan Prasain
  • Publication number: 20170022476
    Abstract: The present disclosure relates generally to methods and compositions useful in cell and tissue biology and therapeutics. In particular, an in vitro method for differentiating pluripotent cells into endothelial colony forming cell-like cells (ECFC-like cells) is provided. A purified human cell population of NRP-1+CD31+ ECFC-like cells is provided, wherein at least some of the cells in the population have a high proliferation potential. Therapeutic and test agent screening methods for using the cell populations of the present disclosure are provided.
    Type: Application
    Filed: March 11, 2015
    Publication date: January 26, 2017
    Inventors: Mervin Yoder, Nutan Prasain