Patents by Inventor Ny Sin

Ny Sin has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Hepatitis C virus inhibitors
    Patent number: 7772180
    Abstract: Hepatitis C virus inhibitors having the general formula are disclosed. Compositions comprising the compounds and methods for using the compounds to inhibit HCV are also disclosed.
    Type: Grant
    Filed: November 5, 2007
    Date of Patent: August 10, 2010
    Assignee: Bristol-Myers Squibb Company
    Inventors: Ny Sin, Brian Lee Venables, Li-Qiang Sun, Sing-Yuen Sit, Yan Chen, Paul Michael Scola
  • Hepatitis C Virus Inhibitors
    Publication number: 20090285774
    Abstract: Hepatitis C virus inhibitors having the general formula are disclosed. Compositions comprising the compounds and methods for using the compounds to inhibit HCV are also disclosed.
    Type: Application
    Filed: May 13, 2009
    Publication date: November 19, 2009
    Inventors: Ny Sin, Brian Lee Venables, Paul Michael Scola
  • HEPATITIS C VIRUS INHIBITORS
    Publication number: 20090274656
    Abstract: Hepatitis C virus inhibitors are disclosed having the general formula: wherein R1, R2, R3, R?, B, Y and X are described in the description. Compositions comprising the compounds and methods for using the compounds to inhibit HCV are also disclosed.
    Type: Application
    Filed: September 2, 2008
    Publication date: November 5, 2009
    Inventors: Alan Xiangdong Wang, Li-Qiang Sun, Sing-Yuen Sit, Ny Sin, Paul Michael Scola, Yan Chen
  • Hepatitis C Virus Inhibitors
    Publication number: 20090274652
    Abstract: Hepatitis C virus inhibitors having the general formula are disclosed. Compositions comprising the compounds and methods for using the compounds to inhibit HCV are also disclosed.
    Type: Application
    Filed: April 6, 2009
    Publication date: November 5, 2009
    Inventors: Ny Sin, Brian Lee Venables, Paul Michael Scola, Alan Xiangdong Wang
  • Hepatitis C virus inhibitors
    Patent number: 7592336
    Abstract: Hepatitis C virus inhibitors having the general formula are disclosed. Compositions comprising the compounds and methods for using the compounds to inhibit HCV are also disclosed.
    Type: Grant
    Filed: May 9, 2006
    Date of Patent: September 22, 2009
    Assignee: Bristol-Myers Squibb Company
    Inventors: Ny Sin, Paul Michael Scola, Nicholas A. Meanwell, Xiangdong Alan Wang, Li-Qiang Sun, Jie Chen, Andrew Charles Good
  • Hepatitis C virus inhibitors
    Patent number: 7449479
    Abstract: Hepatitis C virus inhibitors are disclosed having the general formula: wherein R1, R2, R3, R?, B, Y and X are described in the description. Compositions comprising the compounds and methods for using the compounds to inhibit HCV are also disclosed.
    Type: Grant
    Filed: December 7, 2005
    Date of Patent: November 11, 2008
    Assignee: Bristol-Myers Squibb Company
    Inventors: Xiangdong Alan Wang, Li-Qiang Sun, Sing-Yuen Sit, Ny Sin, Paul Michael Scola, Piyasena Hewawasam, Andrew Charles Good, Yan Chen, Jeffrey Allen Campbell
  • Hepatitis C virus inhibitors
    Publication number: 20080152619
    Abstract: Hepatitis C virus inhibitors having the general formula are disclosed. Compositions comprising the compounds and methods for using the compounds to inhibit HCV are also disclosed.
    Type: Application
    Filed: May 9, 2006
    Publication date: June 26, 2008
    Inventors: Ny Sin, Paul Michael Scola, Nicholas A. Meanwell, Xiangdong Alan Wang, Li-Qiang Sun, Jie Chen, Andrew Charles Good
  • Hepatitis C Virus Inhibitors
    Publication number: 20080119461
    Abstract: Hepatitis C virus inhibitors having the general formula are disclosed. Compositions comprising the compounds and methods for using the compounds to inhibit HCV are also disclosed.
    Type: Application
    Filed: November 5, 2007
    Publication date: May 22, 2008
    Inventors: Ny Sin, Brian Lee Venables, Li-Qiang Sun, Sing-Yuen Sit, Yan Chen, Paul Michael Scola
  • Hepatitis C virus inhibitors
    Patent number: 7323447
    Abstract: The present disclosure is generally directed to antiviral compounds, and more specifically directed to compounds which inhibit the function of the NS3 protease (also referred to herein as “serine protease”) encoded by Hepatitis C virus (HCV), compositions comprising such compounds, and methods for inhibiting the function of the NS3 protease.
    Type: Grant
    Filed: February 6, 2006
    Date of Patent: January 29, 2008
    Assignee: Bristol-Myers Squibb Company
    Inventors: Ny Sin, Andrew Charles Good, Brian Lee Venables, Paul Michael Scola, Nicholas A. Meanwell
  • PROCESS FOR THE PREPARATION OF SUBSTITUTED HETEROCYCLES
    Publication number: 20070161670
    Abstract: The present disclosure generally relates to a process for the preparation of hydroxy-substituted heterocycles such as isoquinolines, naphthyridines, pyridopyridazines, and pyridopyrimidines.
    Type: Application
    Filed: January 4, 2007
    Publication date: July 12, 2007
    Inventors: Andrew J. Staab, Ny Sin
  • Hepatitis C virus inhibitors
    Patent number: 7135462
    Abstract: Hepatitis C virus inhibitors are disclosed having the general formula: wherein A, R2, R3, R?, B and Y are described in the description. Compositions comprising the compounds and methods for using the compounds to inhibit HCV are also disclosed.
    Type: Grant
    Filed: November 18, 2004
    Date of Patent: November 14, 2006
    Assignee: Bristol-Myers Squibb Company
    Inventors: Paul Michael Scola, Jeffrey Allen Campbell, Ny Sin, Li-Qiang Sun, Xiangdong Alan Wang
  • Hepatitis C virus inhibitors
    Publication number: 20060183694
    Abstract: The present disclosure is generally directed to antiviral compounds, and more specifically directed to compounds which inhibit the function of the NS3 protease (also referred to herein as “serine protease”) encoded by Hepatitis C virus (HCV), compositions comprising such compounds, and methods for inhibiting the function of the NS3 protease.
    Type: Application
    Filed: February 6, 2006
    Publication date: August 17, 2006
    Inventors: Ny Sin, Andrew Good, Brian Venables, Paul Scola, Nicholas Meanwell
  • Hepatitis C virus inhibitors
    Publication number: 20060172950
    Abstract: Hepatitis C virus inhibitors are disclosed having the general formula: wherein R1, R2, R3, R?, B, Y and X are described in the description. Compositions comprising the compounds and methods for using the compounds to inhibit HCV are also disclosed.
    Type: Application
    Filed: December 7, 2005
    Publication date: August 3, 2006
    Inventors: Xiangdong Wang, Li-Qiang Sun, Sing-Yuen Sit, Ny Sin, Paul Scola, Piyasena Hewawasam, Andrew Good, Yan Chen, Jeffrey Campbell
  • Hepatitis C virus inhibitors
    Patent number: 7041698
    Abstract: The present invention relates to tripeptide compounds, compositions and methods for the treatment of hepatitis C virus (HCV) infection. In particular, the present invention provides novel tripeptide analogs, pharmaceutical compositions containing such analogs and methods for using these analogs in the treatment of HCV infection.
    Type: Grant
    Filed: May 20, 2003
    Date of Patent: May 9, 2006
    Assignee: Bristol-Myers Squibb Company
    Inventors: Amy Ripka, Jeffrey Allen Campbell, Andrew Charles Good, Paul Michael Scola, Ny Sin, Brian Venables
  • Hepatitis C virus inhibitors
    Patent number: 6995174
    Abstract: Hepatitis C virus inhibitors are disclosed having the general formula: wherein R1, R2, R3, R?, B, Y and X are described in the description. Compositions comprising the compounds and methods for using the compounds to inhibit HCV are also disclosed.
    Type: Grant
    Filed: May 20, 2003
    Date of Patent: February 7, 2006
    Assignee: Bristol-Myers Squibb Company
    Inventors: Xiangdong Alan Wang, Li-Qiang Sun, Sing-Yuen Sit, Ny Sin, Paul Michael Scola, Piyasena Hewawasam, Andrew Charles Good, Yan Chen, Jeffrey Allen Campbell
  • Hepatitis C virus inhibitors
    Publication number: 20050267040
    Abstract: Hepatitis C virus inhibitors are having the general formula: wherein A, R2, R3, R?, B and Y are described in the description. Compositions comprising the compounds and methods for using the compounds to inhibit HCV are also disclosed.
    Type: Application
    Filed: November 18, 2004
    Publication date: December 1, 2005
    Inventors: Paul Scola, Jeffrey Campbell, Ny Sin, Li-Qiang Sun, Xiangdong Wang
  • Heterocyclic substituted 2-methyl-benzimidazole antiviral agents
    Patent number: 6844342
    Abstract: The present invention concerns antiviral compounds, their methods of preparation and their compositions, and use in the treatment of viral infections. More particularly, the invention provides heterocyclic substituted 2-methylbenzimidazole derivatives for the treatment of respiratory syncytial virus infection.
    Type: Grant
    Filed: August 19, 2003
    Date of Patent: January 18, 2005
    Assignee: Bristol-Myers Squibb Company
    Inventors: Kuo-Long Yu, Rita L. Civiello, Keith D. Combrink, Hatice Belgin Gulgeze, Ny Sin, Xiangdong Wang, Nicholas Meanwell, Brian Lee Venables, Yi Zhang, Bradley C. Pearc, Zhiwei Yin, Jan Willem Thuring
  • Enzyme inhibition
    Patent number: 6831099
    Abstract: Peptide-based compounds including heteroatom-containing, three-membered rings efficiently and selectively inhibit specific activities of N-terminal nucleophile (Ntn) hydrolases. The activities of those Ntn having multiple activities can be differentially inhibited by the compounds described. For example, the chymotrypsin-like and PGPH activities of the 20S proteasome can be selectively inhibited with the inventive compounds. The peptide-based compounds include an electron withdrawing group adjacent to the ring functionality, and the peptide include at least three peptide units. Among other therapeutic utilities, the peptide-based compounds exhibit anti-inflammatory and inhibition of cell proliferation, involving therapeutic applications for these compounds.
    Type: Grant
    Filed: May 11, 2000
    Date of Patent: December 14, 2004
    Assignee: Yale University
    Inventors: Craig M. Crews, Mikael Elofsson, Ute Splittgerber, Ny Sin, Kyung Bo Kim
  • Heterocyclic substituted 2-methyl-benzimidazole antiviral agents
    Patent number: 6774134
    Abstract: The present invention concerns antiviral compounds, their methods of preparation and their compositions, and use in the treatment of viral infections. More particularly, the invention provides heterocyclic substituted 2-methylbenzimidazole derivatives for the treatment of respiratory syncytial virus infection.
    Type: Grant
    Filed: November 16, 2001
    Date of Patent: August 10, 2004
    Assignee: Bristol-Myers Squibb Company
    Inventors: Kuo-Long Yu, Rita L. Civiello, Keith D. Combrink, Hatice Belgin Gulgeze, Ny Sin, Xiangdong Wang, Nicholas Meanwell, Brian Lee Venables, Yi Zhang, Bradley C. Pearce, Zhiwei Yin, Jan Willem Thuring
  • Hepatitis C virus inhibitors
    Publication number: 20040106559
    Abstract: Hepatitis C virus inhibitors are disclosed having the general formula: 1
    Type: Application
    Filed: May 20, 2003
    Publication date: June 3, 2004
    Inventors: Xiangdong Alan Wang, Li-Qiang Sun, Sing-Yuen Sit, Ny Sin, Paul Michael Scola, Piyasena Hewawasam, Andrew Charles Good, Yan Chen, Jeffrey Allen Campbell