Patents by Inventor O. Burak Ozdoganlar

O. Burak Ozdoganlar has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20220193386
    Abstract: A method of forming a microneedle array can include forming a microneedle array having one or more chemotherapeutic agents. The microneedle array can include a base portion and plurality of microneedles extending from the base portion, and the one or more chemotherapeutic agents can be present in a higher concentration in the plurality of microneedles than in the base portion.
    Type: Application
    Filed: January 14, 2022
    Publication date: June 23, 2022
    Applicants: University of Pittsburgh - Of the Commonwealth System of Higher Education, Carnegie Mellon University
    Inventors: Louis D. Falo, JR., Geza Erdos, O. Burak Ozdoganlar
  • Publication number: 20220176116
    Abstract: An electro-stimulation apparatus provides stimulation of the supplementary motor area, premotor area, cerebellum and/or subthalamic nucleus of a human. The electro-stimulation apparatus includes at least one micro needle electrode having a stimulation end and a base. Said at least one micro needle electrode is provided with a stimulation end configured to stimulate intrinsic auricular muscles of the human and said stimulation end of said micro needle electrode is adapted to generate an electrical stimulation signal during a stimulating state.
    Type: Application
    Filed: December 8, 2021
    Publication date: June 9, 2022
    Applicant: Stoparkinson Healthcare Systems, LLC
    Inventors: O. Burak Özdoganlar, Yusuf Özgür Çakmak, Burak Özsoy, Yalin Geçer, Ali Cem Soysal
  • Publication number: 20210307912
    Abstract: A system and method used to fabricate an implant from cartilage, where the implant can be used in reconstructive surgery. The system includes a thermoregulation device capable of maintaining a desired temperature range during milling operations. The milling machine is controlled by instructions generated from a digital model of the implant. The digital model can be a stock model or a custom model created from medical scans.
    Type: Application
    Filed: April 1, 2021
    Publication date: October 7, 2021
    Applicants: CARNEGIE MELLON UNIVERSITY, University of Pittsburgh - Of the Commonwealth System of Higher Education
    Inventors: Liliana Camison Bravo, Phil G. Campbell, Toygun Cetinkaya, O. Burak Ozdoganlar, Lucas A. Dvoracek, Jesse A. Goldstein
  • Publication number: 20210187262
    Abstract: Provided herein are devices and methods used to produce tattoo biosensors that are based on spatially controlled intracutaneous gene delivery of optical reporters driven by specific transcription factor pathways for a given cytokine or other analyte. The biosensors can be specific to a given analyte, or more generically represent the convergence of several cytokines into commonly shared intracellular transcription factor pathways. These biosensors can be delivered as an array in order to monitor multiple cytokines. Biosensor redeployment can enable chronic monitoring from months to years. The tattooed biosensor array of the present invention includes endogenous reporter cells, naturally tuned to each patient's own biology and can be used to reliably measure the state of a patient in real-time.
    Type: Application
    Filed: December 23, 2020
    Publication date: June 24, 2021
    Inventors: O. Burak Ozdoganlar, Marcel P. Bruchez, Phil G. Campbell, Jonathan W. Jarvik, Louis Falo, Geza Erdos
  • Publication number: 20210178636
    Abstract: The present invention relates generally to a method that is used to create three-dimensional synthetic vascular networks. Micromachining and molding techniques are used to create a template in a shape that mimics a biological network. Cellular material can be seeded around the template or a space created by the template and grown into an engineered tissue-construct.
    Type: Application
    Filed: February 8, 2021
    Publication date: June 17, 2021
    Applicants: CARNEGIE MELLON UNIVERSITY, University of Pittsburgh - Of the Commonwealth System of Higher Education
    Inventors: Philip R. LeDuc, O. Burak Ozdoganlar, Mary E. Wilson, Emrullah Korkmaz, Yadong Wang, Donna Beer-Stolz
  • Patent number: 10919183
    Abstract: The present invention relates generally to a method that is used to create three-dimensional synthetic vascular networks. Micromachining and molding techniques are used to create a template in a shape that mimics a biological network. Cellular material can be seeded around the template or a space created by the template and grown into an engineered tissue-construct.
    Type: Grant
    Filed: June 25, 2015
    Date of Patent: February 16, 2021
    Assignees: CARNEGIE MELLON UNIVERSITY, a Pennsylvania Non-Profit Corporation, University of Pittsburgh—Of the Commonwealth System of Higher Education
    Inventors: Philip R. LeDuc, O. Burak Ozdoganlar, Mary E. Wilson, Emrullah Korkmaz, Yadong Wang, Donna Beer-Stolz
  • Patent number: 10894151
    Abstract: Provided herein are devices and methods used to produce tattoo biosensors that are based on spatially controlled intracutaneous gene delivery of optical reporters driven by specific transcription factor pathways for a given cytokine or other analyte. The biosensors can be specific to a given analyte, or more generically represent the convergence of several cytokines into commonly shared intracellular transcription factor pathways. These biosensors can be delivered as an array in order to monitor multiple cytokines. Biosensor redeployment can enable chronic monitoring from months to years. The tattooed biosensor array of the present invention includes endogenous reporter cells, naturally tuned to each patient's own biology and can be used to reliably measure the state of a patient in real-time.
    Type: Grant
    Filed: April 22, 2016
    Date of Patent: January 19, 2021
    Assignees: Carnegie Mellon University, University of Pittsburgh—Of the Commonwealth System of Higher Education
    Inventors: O. Burak Ozdoganlar, Marcel P. Bruchez, Phil G. Campbell, Jonathan W. Jarvik, Louis Falo, Geza Erdos
  • Publication number: 20200397955
    Abstract: A method of forming a microneedle array can include forming a sheet of material having a plurality of layers and micromilling the sheet of material to form a microneedle array. At least one of the plurality of layers can include a bioactive component, and the microneedle array can include a base portion and plurality of microneedles extending from the base portion.
    Type: Application
    Filed: April 28, 2020
    Publication date: December 24, 2020
    Applicants: University of Pittsburgh - Of the Commonwealth System of Higher Education, Carnegie Mellon University
    Inventors: Louis D. Falo, JR., Geza Erdos, O. Burak Ozdoganlar
  • Publication number: 20200296825
    Abstract: Manufacturing technology to fabricate liquid metal-based soft and flexible electronics (sensors, antennas, etc.) in a high-throughput fashion, with fabrication rates that may approach that of the traditional integrated circuit components and circuits, are described. The technique allows creation of liquid-metal-only circuits, as well as seamless integration of solid IC chips into the circuits, in which liquid metal traces are used as flexible interconnects and/or as other circuit elements. The process may be applied at the wafer scale and may be integrated into the traditional microelectronics fabrication processes. Many sensors, antennas, and other circuit elements may be directly created using liquid metal, and when combined with the IC chips, a broad range of electronic functionality may be provided in a flexible, soft circuit that can be conformable, wearable.
    Type: Application
    Filed: March 12, 2020
    Publication date: September 17, 2020
    Applicant: Carnegie Mellon University
    Inventors: O Burak Ozdoganlar, Carmel Majidi, Kadri Bugra Ozutemiz, James Wissman
  • Publication number: 20200070249
    Abstract: A method and apparatus for conformal surface finishing and/or forming of additive manufactured products and an improved system for a combined electrolytic removal of material followed by precise mechanical cleaning and removal of excess material to create improved precision in a single stage without requiring the use of a grinding wheel. An automated computerized embodiment is disclosed.
    Type: Application
    Filed: September 4, 2018
    Publication date: March 5, 2020
    Applicant: OBERG INDUSTRIES
    Inventors: O. BURAK OZDOGANLAR, JOSEPH A. DEANGELO
  • Publication number: 20200047401
    Abstract: A method and device for fabricating vascular networks in for tissue engineering. The vascular network is embedded in a porous scaffold and is created from a sacrificial wax template, according to one embodiment. A extrusion-based three dimensional printer is used to create the template, wherein the printer utilizes an extruder incorporating a mixer to maintain the consistency of the extrudate.
    Type: Application
    Filed: August 9, 2019
    Publication date: February 13, 2020
    Applicant: CARNEGIE MELLON UNIVERSITY
    Inventors: Zhou Yu, Philip R. LeDuc, O. Burak Ozdoganlar
  • Patent number: 10350021
    Abstract: Apparatus and method for surgeon-assisted rapid surgical implantation of devices into soft tissue. The apparatus comprises several subsystems that enable the referencing of the spatial position and orientation of the device being implanted with respect to the soft tissue into which it is being implanted and then the controlled implantation of the device at a predefined speed with higher positional accuracy and precision and a reduction in soft tissue damage, provided by ultrasonic assisted motion, compared to current state-of-the-art implantation methods and devices.
    Type: Grant
    Filed: August 8, 2016
    Date of Patent: July 16, 2019
    Assignee: CARNEGIE MELLON UNIVERSITY
    Inventors: Peter J. Gilgunn, O. Burak Ozdoganlar, Takashi Daniel Yoshida Kozai, Gary Fedder, Xinyan Cui, Douglas J. Weber
  • Publication number: 20180272621
    Abstract: A method of forming a microneedle array can include forming a microneedle array that has one or more bioactive component. The microneedle array can include a base portion and plurality of microneedles extending from the base portion, and the one or more bioactive components are present in a higher concentration in the plurality of microneedles than in the base portion.
    Type: Application
    Filed: March 26, 2018
    Publication date: September 27, 2018
    Applicants: University of Pittsburgh - Of the Commonwealth System of Higher Education, Carnegie Mellon University
    Inventors: Louis D. Falo, Jr., Geza Erdos, O. Burak Ozdoganlar
  • Publication number: 20180119077
    Abstract: Provided herein are devices and methods used to produce tattoo biosensors that are based on spatially controlled intracutaneous gene delivery of optical reporters driven by specific transcription factor pathways for a given cytokine or other analyte. The biosensors can be specific to a given analyte, or more generically represent the convergence of several cytokines into commonly shared intracellular transcription factor pathways. These biosensors can be delivered as an array in order to monitor multiple cytokines. Biosensor redeployment can enable chronic monitoring from months to years. The tattooed biosensor array of the present invention includes endogenous reporter cells, naturally tuned to each patient's own biology and can be used to reliably measure the state of a patient in real-time.
    Type: Application
    Filed: April 22, 2016
    Publication date: May 3, 2018
    Inventors: O. Burak Ozdoganlar, Marcel P. Bruchez, Phil G. Campbell, Jonathan W. Jarvik, Louis Falo, Geza Erdos
  • Patent number: 9944019
    Abstract: A method of forming a microneedle array can include forming a microneedle array that has one or more bioactive component. The microneedle array can include a base portion and plurality of microneedles extending from the base portion, and the one or more bioactive components are present in a higher concentration in the plurality of microneedles than in the base portion.
    Type: Grant
    Filed: May 1, 2013
    Date of Patent: April 17, 2018
    Assignees: University of Pittsburgh—Of the Commonwealth System of Higher Education, Carnegie Mellon University
    Inventors: Louis D. Falo, Jr., Geza Erdos, O. Burak Ozdoganlar
  • Publication number: 20170156815
    Abstract: Apparatus and method for surgeon-assisted rapid surgical implantation of devices into soft tissue. The apparatus comprises several subsystems that enable the referencing of the spatial position and orientation of the device being implanted with respect to the soft tissue into which it is being implanted and then the controlled implantation of the device at a predefined speed with higher positional accuracy and precision and a reduction in soft tissue damage, provided by ultrasonic assisted motion, compared to current state-of-the-art implantation methods and devices.
    Type: Application
    Filed: August 8, 2016
    Publication date: June 8, 2017
    Applicants: CARNEGIE MELLON UNIVERSITY, a Pennsylvania Non-Profit Corporation, University of Pittsburgh - Of the Commonwealth System of Higher Education
    Inventors: Peter J. Gilgunn, O. Burak Ozdoganlar, Takashi Daniel Yoshida Kozai, Gary Fedder, Xinyan Cui, Douglas J. Weber
  • Patent number: 9408571
    Abstract: Apparatus and method for surgeon-assisted rapid surgical implantation of devices into soft tissue. The apparatus comprises several subsystems that enable the referencing of the spatial position and orientation of the device being implanted with respect to the soft tissue into which it is being implanted and then the controlled implantation of the device at a predefined speed with higher positional accuracy and precision and a reduction in soft tissue damage, provided by ultrasonic assisted motion, compared to current state-of-the-art implantation methods and devices.
    Type: Grant
    Filed: June 18, 2013
    Date of Patent: August 9, 2016
    Assignees: Carnegie Mellon University, University of Pittsburgh—Of the Commonwealth System of Higher Education
    Inventors: Peter J. Gilgunn, O. Burak Ozdoganlar, Takashi Daniel Yoshida Kozai, Gary Fedder, Xinyan Cui, Douglas J. Weber
  • Publication number: 20160136407
    Abstract: A method of forming a microneedle array can include forming a microneedle array having one or more chemotherapeutic agents. The microneedle array can include a base portion and plurality of microneedles extending from the base portion, and the one or more chemotherapeutic agents can be present in a higher concentration in the plurality of microneedles than in the base portion.
    Type: Application
    Filed: November 6, 2015
    Publication date: May 19, 2016
    Applicants: University of Pittsburgh - Of the Commonwealth System of Higher Education, Carnegie Mellon University
    Inventors: Louis D. Falo, JR., Geza Erdos, O. Burak Ozdoganlar
  • Publication number: 20150376595
    Abstract: The present invention relates generally to a method that is used to create three-dimensional synthetic vascular networks. Micromachining and molding techniques are used to create a template in a shape that mimics a biological network. Cellular material can be seeded around the template or a space created by the template and grown into an engineered tissue-construct.
    Type: Application
    Filed: June 25, 2015
    Publication date: December 31, 2015
    Applicants: CARNEGIE MELLON UNIVERSITY, a Pennsylvania Non-Profit Corporation, University of Pittsburgh - Of the Commonwealth System of Higher Education
    Inventors: Philip R. LeDuc, O. Burak Ozdoganlar, Mary E. Wilson, Emrullah Korkmaz, Yadong Wang, Donna Beer-Stolz
  • Publication number: 20150126923
    Abstract: A method of forming a microneedle array can include forming a microneedle array that has one or more bioactive component. The microneedle array can include a base portion and plurality of microneedles extending from the base portion, and the one or more bioactive components are present in a higher concentration in the plurality of microneedles than in the base portion.
    Type: Application
    Filed: May 1, 2013
    Publication date: May 7, 2015
    Inventors: Louis D. Falo, JR., Geza Erdos, O. Burak Ozdoganlar