Patents by Inventor O. Burak Ozdoganlar
O. Burak Ozdoganlar has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240032189Abstract: Manufacturing technology to fabricate liquid metal-based soft and flexible electronics (sensors, antennas, etc.) in a high-throughput fashion, with fabrication rates that may approach that of the traditional integrated circuit components and circuits, are described. The technique allows creation of liquid-metal-only circuits, as well as seamless integration of solid IC chips into the circuits, in which liquid metal traces are used as flexible interconnects and/or as other circuit elements. The process may be applied at the wafer scale and may be integrated into the traditional microelectronics fabrication processes. Many sensors, antennas, and other circuit elements may be directly created using liquid metal, and when combined with the IC chips, a broad range of electronic functionality may be provided in a flexible, soft circuit that can be conformable, wearable.Type: ApplicationFiled: October 5, 2023Publication date: January 25, 2024Applicant: Carnegie Mellon UniversityInventors: O. Burak OZDOGANLAR, Carmel MAJIDI, Kadri Bugra OZUTEMIZ, James WISSMAN
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Publication number: 20230404929Abstract: A therapeutic delivery system uses an engineered extracellular vesicle-albumin hybrid carrier for curcumin, which is embedded in dissolvable microneedle arrays. The co-encapsulation of curcumin with albumin in extracellular vesicles extends curcumin's stability. The incorporation of therapeutic loaded carrier into microneedle arrays does not alter its cell uptake properties or bioactivity. Moreover, the bioactivity of therapeutic loaded carrier can be preserved for at least one year when encapsulated in microneedle arrays and stored under room temperature storage conditions. The microneedle arrays of the delivery system are fabricated using molding and casting processes. The extracellular vesicle carrier can be loaded using sonication.Type: ApplicationFiled: December 1, 2021Publication date: December 21, 2023Applicant: Carnegie Mellon UniversityInventors: O. Burak Ozdoganlar, Phil G. Campbell, Saigopalakrishna Saileelaprasa Yerneni, Ezgi Pinar Yalcintas
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Patent number: 11805597Abstract: A high-throughput method of manufacturing a liquid metal circuit may include applying a liquid metal to an alloying metal pattern on an elastic substrate to form the liquid metal circuit. The elastic substrate may have a surface area greater than 1 square inch. The liquid metal circuit may include a plurality of liquid metal circuits on the elastic substrate. Methods of using the liquid metal circuit are also described.Type: GrantFiled: March 12, 2020Date of Patent: October 31, 2023Assignee: CARNEGIE MELLON UNIVERSITYInventors: O Burak Ozdoganlar, Carmel Majidi, Kadri Bugra Ozutemiz, James Wissman
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Publication number: 20230311426Abstract: A method of forming a microneedle array can include forming a microneedle array that has one or more bioactive component. The microneedle array can include a base portion and plurality of microneedles extending from the base portion, and the one or more bioactive components are present in a higher concentration in the plurality of microneedles than in the base portion.Type: ApplicationFiled: March 8, 2023Publication date: October 5, 2023Applicants: University of Pittsburgh - Of the Commonwealth System of Higher Education, Carnegie Mellon UniversityInventors: Louis D. Falo, JR., Geza Erdos, O. Burak Ozdoganlar
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Patent number: 11744927Abstract: A method of forming a microneedle array can include forming a sheet of material having a plurality of layers and micromilling the sheet of material to form a microneedle array. At least one of the plurality of layers can include a bioactive component, and the microneedle array can include a base portion and plurality of microneedles extending from the base portion.Type: GrantFiled: April 28, 2020Date of Patent: September 5, 2023Assignees: University of Pittsburgh—Of the Commonwealth System of Higher Education, Carnegie Mellon UniversityInventors: Louis D. Falo, Jr., Geza Erdos, O. Burak Ozdoganlar
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Publication number: 20230141251Abstract: A device to collect a biological sample may generally include an elongated rod having a handle and terminating in a tip; and a core and a plurality of projections extending in a radial direction from a surface of the core. The projections may have curved geometric pattern, such as a sinusoidal pattern, a circular arc pattern, and/or a helical pattern, for example. The device may include a layer of fibers disposed on a surface of the projections by flocking. Method of making and using the device are also described.Type: ApplicationFiled: April 23, 2021Publication date: May 11, 2023Inventors: O. Burak OZDOGANLAR, Yusuf SENTURK, Toygun CETINKAYA, Ant YUCESOY, Ali GURER, Lisha WHITE, Ezgi YALCINTAS
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Publication number: 20230134699Abstract: A hybrid microneedle array and a method of fabricating the array is used for delivery of drugs, vaccines, and other therapeutic agents into tissues, including skin, heart, inner ear, and other tissues. The microneedle array can facilitate precise and reproducible intradermal delivery. Each microneedle has a dissolvable tip with a hollow body permitting the delivery of a variety of therapeutic agents into the skin. A fabrication process utilizes a two part mold to separately mold a dissolvable tip and a solid body portion of each microneedle in the array.Type: ApplicationFiled: April 9, 2021Publication date: May 4, 2023Applicant: Carnegie Mellon UniversityInventors: O. Burak Ozdoganlar, Ant Yucesoy
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Patent number: 11639021Abstract: A method and device for fabricating vascular networks in for tissue engineering. The vascular network is embedded in a porous scaffold and is created from a sacrificial wax template, according to one embodiment. A extrusion-based three dimensional printer is used to create the template, wherein the printer utilizes an extruder incorporating a mixer to maintain the consistency of the extrudate.Type: GrantFiled: August 9, 2019Date of Patent: May 2, 2023Assignee: CARNEGIE MELLON UNIVERSITYInventors: Zhou Yu, Philip R. LeDuc, O. Burak Ozdoganlar
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Patent number: 11540921Abstract: A system and method used to fabricate an implant from cartilage, where the implant can be used in reconstructive surgery. The system includes a thermoregulation device capable of maintaining a desired temperature range during milling operations. The milling machine is controlled by instructions generated from a digital model of the implant. The digital model can be a stock model or a custom model created from medical scans.Type: GrantFiled: April 1, 2021Date of Patent: January 3, 2023Assignees: Carnegie Mellon University, University of Pittsburgh—Of the Commonwealth System of Higher EducationInventors: Liliana Camison Bravo, Phil G. Campbell, Toygun Cetinkaya, O. Burak Ozdoganlar, Lucas A. Dvoracek, Jesse A. Goldstein
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Publication number: 20220193386Abstract: A method of forming a microneedle array can include forming a microneedle array having one or more chemotherapeutic agents. The microneedle array can include a base portion and plurality of microneedles extending from the base portion, and the one or more chemotherapeutic agents can be present in a higher concentration in the plurality of microneedles than in the base portion.Type: ApplicationFiled: January 14, 2022Publication date: June 23, 2022Applicants: University of Pittsburgh - Of the Commonwealth System of Higher Education, Carnegie Mellon UniversityInventors: Louis D. Falo, JR., Geza Erdos, O. Burak Ozdoganlar
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Publication number: 20220176116Abstract: An electro-stimulation apparatus provides stimulation of the supplementary motor area, premotor area, cerebellum and/or subthalamic nucleus of a human. The electro-stimulation apparatus includes at least one micro needle electrode having a stimulation end and a base. Said at least one micro needle electrode is provided with a stimulation end configured to stimulate intrinsic auricular muscles of the human and said stimulation end of said micro needle electrode is adapted to generate an electrical stimulation signal during a stimulating state.Type: ApplicationFiled: December 8, 2021Publication date: June 9, 2022Applicant: Stoparkinson Healthcare Systems, LLCInventors: O. Burak Özdoganlar, Yusuf Özgür Çakmak, Burak Özsoy, Yalin Geçer, Ali Cem Soysal
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Publication number: 20210307912Abstract: A system and method used to fabricate an implant from cartilage, where the implant can be used in reconstructive surgery. The system includes a thermoregulation device capable of maintaining a desired temperature range during milling operations. The milling machine is controlled by instructions generated from a digital model of the implant. The digital model can be a stock model or a custom model created from medical scans.Type: ApplicationFiled: April 1, 2021Publication date: October 7, 2021Applicants: CARNEGIE MELLON UNIVERSITY, University of Pittsburgh - Of the Commonwealth System of Higher EducationInventors: Liliana Camison Bravo, Phil G. Campbell, Toygun Cetinkaya, O. Burak Ozdoganlar, Lucas A. Dvoracek, Jesse A. Goldstein
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Publication number: 20210187262Abstract: Provided herein are devices and methods used to produce tattoo biosensors that are based on spatially controlled intracutaneous gene delivery of optical reporters driven by specific transcription factor pathways for a given cytokine or other analyte. The biosensors can be specific to a given analyte, or more generically represent the convergence of several cytokines into commonly shared intracellular transcription factor pathways. These biosensors can be delivered as an array in order to monitor multiple cytokines. Biosensor redeployment can enable chronic monitoring from months to years. The tattooed biosensor array of the present invention includes endogenous reporter cells, naturally tuned to each patient's own biology and can be used to reliably measure the state of a patient in real-time.Type: ApplicationFiled: December 23, 2020Publication date: June 24, 2021Inventors: O. Burak Ozdoganlar, Marcel P. Bruchez, Phil G. Campbell, Jonathan W. Jarvik, Louis Falo, Geza Erdos
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Publication number: 20210178636Abstract: The present invention relates generally to a method that is used to create three-dimensional synthetic vascular networks. Micromachining and molding techniques are used to create a template in a shape that mimics a biological network. Cellular material can be seeded around the template or a space created by the template and grown into an engineered tissue-construct.Type: ApplicationFiled: February 8, 2021Publication date: June 17, 2021Applicants: CARNEGIE MELLON UNIVERSITY, University of Pittsburgh - Of the Commonwealth System of Higher EducationInventors: Philip R. LeDuc, O. Burak Ozdoganlar, Mary E. Wilson, Emrullah Korkmaz, Yadong Wang, Donna Beer-Stolz
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Patent number: 10919183Abstract: The present invention relates generally to a method that is used to create three-dimensional synthetic vascular networks. Micromachining and molding techniques are used to create a template in a shape that mimics a biological network. Cellular material can be seeded around the template or a space created by the template and grown into an engineered tissue-construct.Type: GrantFiled: June 25, 2015Date of Patent: February 16, 2021Assignees: CARNEGIE MELLON UNIVERSITY, a Pennsylvania Non-Profit Corporation, University of Pittsburgh—Of the Commonwealth System of Higher EducationInventors: Philip R. LeDuc, O. Burak Ozdoganlar, Mary E. Wilson, Emrullah Korkmaz, Yadong Wang, Donna Beer-Stolz
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Patent number: 10894151Abstract: Provided herein are devices and methods used to produce tattoo biosensors that are based on spatially controlled intracutaneous gene delivery of optical reporters driven by specific transcription factor pathways for a given cytokine or other analyte. The biosensors can be specific to a given analyte, or more generically represent the convergence of several cytokines into commonly shared intracellular transcription factor pathways. These biosensors can be delivered as an array in order to monitor multiple cytokines. Biosensor redeployment can enable chronic monitoring from months to years. The tattooed biosensor array of the present invention includes endogenous reporter cells, naturally tuned to each patient's own biology and can be used to reliably measure the state of a patient in real-time.Type: GrantFiled: April 22, 2016Date of Patent: January 19, 2021Assignees: Carnegie Mellon University, University of Pittsburgh—Of the Commonwealth System of Higher EducationInventors: O. Burak Ozdoganlar, Marcel P. Bruchez, Phil G. Campbell, Jonathan W. Jarvik, Louis Falo, Geza Erdos
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Publication number: 20200397955Abstract: A method of forming a microneedle array can include forming a sheet of material having a plurality of layers and micromilling the sheet of material to form a microneedle array. At least one of the plurality of layers can include a bioactive component, and the microneedle array can include a base portion and plurality of microneedles extending from the base portion.Type: ApplicationFiled: April 28, 2020Publication date: December 24, 2020Applicants: University of Pittsburgh - Of the Commonwealth System of Higher Education, Carnegie Mellon UniversityInventors: Louis D. Falo, JR., Geza Erdos, O. Burak Ozdoganlar
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Patent number: D977089Type: GrantFiled: April 23, 2021Date of Patent: January 31, 2023Assignee: Carnegie Mellon UniversityInventors: O. Burak Ozdoganlar, Yusuf Mert Senturk, Toygun Cetinkaya, Ant Yucesoy, Ali Alp Gurer, Lisha White, Ezgi Pinar Yalcintas
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Patent number: D977090Type: GrantFiled: April 23, 2021Date of Patent: January 31, 2023Assignee: Carnegie Mellon UniversityInventors: O. Burak Ozdoganlar, Yusuf Mert Senturk, Toygun Cetinkaya, Ant Yucesoy, Ali Alp Gurer, Lisha White, Ezgi Pinar Yalcintas
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Patent number: D977091Type: GrantFiled: April 23, 2021Date of Patent: January 31, 2023Assignee: Carnegie Mellon UniversityInventors: O. Burak Ozdoganlar, Yusuf Mert Senturk, Toygun Cetinkaya, Ant Yucesoy, Ali Alp Gurer, Lisha White, Ezgi Pinar Yalcintas