Patents by Inventor O'neil W. Guthrie

O'neil W. Guthrie has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods and Compositions for Preventing and Treating Auditory Dysfunctions
    Publication number: 20240024271
    Abstract: The invention provides methods for treating auditory impairments in a subject in need of treatment comprising administering to said subject an effective amount of a composition comprising, as an active agent, one or more of a carboxy alkyl ester, a quinic acid derivative, a caffeic acid derivative, a ferulic acid derivative, or a quinic acid lactone or derivative thereof or pharmaceutically acceptable salt thereof and an acceptable carrier or excipient, so as to treat auditory impairments in the subject.
    Type: Application
    Filed: September 27, 2023
    Publication date: January 25, 2024
    Inventor: O'Neil W. Guthrie
  • Methods and Compositions for Preventing and Treating Auditory Dysfunctions
    Publication number: 20210236450
    Abstract: The invention provides methods for treating auditory impairments in a subject in need of treatment comprising administering to said subject an effective amount of a composition comprising, as an active agent, one or more of a carboxy alkyl ester, a quinic acid derivative, a caffeic acid derivative, a ferulic acid derivative, or a quinic acid lactone or derivative thereof or pharmaceutically acceptable salt thereof and an acceptable carrier or excipient, so as to treat auditory impairments in the subject.
    Type: Application
    Filed: April 13, 2021
    Publication date: August 5, 2021
    Inventor: O'Neil W. Guthrie
  • Methods and compositions for preventing and treating auditory dysfunctions
    Patent number: 10987333
    Abstract: The invention provides methods for treating auditory impairments in a subject in need of treatment comprising administering to said subject an effective amount of a composition comprising, as an active agent, one or more of a carboxy alkyl ester, a quinic acid derivative, a caffeic acid derivative, a ferulic acid derivative, or a quinic acid lactone or derivative thereof or pharmaceutically acceptable salt thereof and an acceptable carrier or excipient, so as to treat auditory impairments in the subject.
    Type: Grant
    Filed: July 9, 2019
    Date of Patent: April 27, 2021
    Assignee: United States Government as represented by the Department of Veterans Affairs
    Inventor: O'Neil W. Guthrie
  • Methods and Compositions for Preventing and Treating Auditory Dysfunctions
    Publication number: 20200069628
    Abstract: The invention provides methods for treating auditory impairments in a subject in need of treatment comprising administering to said subject an effective amount of a composition comprising, as an active agent, one or more of a carboxy alkyl ester, a quinic acid derivative, a caffeic acid derivative, a ferulic acid derivative, or a quinic acid lactone or derivative thereof or pharmaceutically acceptable salt thereof and an acceptable carrier or excipient, so as to treat auditory impairments in the subject.
    Type: Application
    Filed: July 9, 2019
    Publication date: March 5, 2020
    Inventor: O'Neil W. Guthrie
  • Methods of treating, inhibiting and/or preventing an auditory impairment
    Patent number: 10124062
    Abstract: The present invention provides methods of treating an auditory impairment associated with outer hair cells of the cochlea in a subject. The method may comprise administering to said subject an effective amount of a composition comprising, as an active agent, an oligonucleotide sequence having a portion of a mammalian telomere sequence so as to reduce the auditory impairment thereby treating the auditory impairment in the subject.
    Type: Grant
    Filed: February 27, 2017
    Date of Patent: November 13, 2018
    Assignee: The United States of America as represented by the Department of Veterans Affairs
    Inventor: O'neil W. Guthrie
  • Methods and compositions for preventing and treating auditory dysfunctions
    Patent number: 9889107
    Abstract: The invention provides methods for treating auditory impairments in a subject in need of treatment comprising administering to said subject an effective amount of a composition comprising, as an active agent, one or more of a carboxy alkyl ester, a quinic acid derivative, a caffeic acid derivative, a ferulic acid derivative, or a quinic acid lactone or derivative thereof or pharmaceutically acceptable salt thereof and an acceptable carrier or excipient, so as to treat auditory impairments in the subject.
    Type: Grant
    Filed: August 5, 2016
    Date of Patent: February 13, 2018
    Assignee: The United States of America as represented by the Department of Veterans Affairs
    Inventor: O'neil W. Guthrie
  • METHODS OF TREATING, INHIBITING AND/OR PREVENTING AN AUDITORY IMPAIRMENT
    Publication number: 20170260525
    Abstract: The present invention provides methods of treating an auditory impairment associated with outer hair cells of the cochlea in a subject. The method may comprise administering to said subject an effective amount of a composition comprising, as an active agent, an oligonucleotide sequence having a portion of a mammalian telomere sequence so as to reduce the auditory impairment thereby treating the auditory impairment in the subject.
    Type: Application
    Filed: February 27, 2017
    Publication date: September 14, 2017
    Inventor: O'neil W. Guthrie
  • METHODS AND COMPOSITIONS FOR PREVENTING AND TREATING AUDITORY DYSFUNCTIONS
    Publication number: 20160338986
    Abstract: The invention provides methods for treating auditory impairments in a subject in need of treatment comprising administering to said subject an effective amount of a composition comprising, as an active agent, one or more of a carboxy alkyl ester, a quinic acid derivative, a caffeic acid derivative, a ferulic acid derivative, or a quinic acid lactone or derivative thereof or pharmaceutically acceptable salt thereof and an acceptable carrier or excipient, so as to treat auditory impairments in the subject.
    Type: Application
    Filed: August 5, 2016
    Publication date: November 24, 2016
    Inventor: O'neil W. Guthrie
  • Methods and compositions for preventing and treating auditory dysfunctions
    Patent number: 9457009
    Abstract: The invention provides methods for treating auditory impairments in a subject in need of treatment comprising administering to said subject an effective amount of a composition comprising, as an active agent, one or more of a carboxy alkyl ester, a quinic acid derivative, a caffeic acid derivative, a ferulic acid derivative, or a quinic acid lactone or derivative thereof or pharmaceutically acceptable salt thereof and an acceptable carrier or excipient, so as to treat auditory impairments in the subject.
    Type: Grant
    Filed: May 31, 2013
    Date of Patent: October 4, 2016
    Assignee: THE UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS
    Inventor: O'neil W. Guthrie
  • METHODS AND COMPOSITIONS FOR PREVENTING AND TREATING AUDITORY DYSFUNCTIONS
    Publication number: 20130324594
    Abstract: The invention provides methods for treating auditory impairments in a subject in need of treatment comprising administering to said subject an effective amount of a composition comprising, as an active agent, one or more of a carboxy alkyl ester, a quinic acid derivative, a caffeic acid derivative, a ferulic acid derivative, or a quinic acid lactone or derivative thereof or pharmaceutically acceptable salt thereof and an acceptable carrier or excipient, so as to treat auditory impairments in the subject.
    Type: Application
    Filed: May 31, 2013
    Publication date: December 5, 2013
    Inventor: O'neil W. Guthrie