Patents by Inventor Octavian Lungu

Octavian Lungu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • VZV ORF29p protein-related compositions and methods
    Patent number: 6809182
    Abstract: The present invention provides compositions of matter comprising 29p protein having bound thereto an agent whose delivery into a eukaryotic cell is desired. The present invention also provides a monoclonal antibody which specifically binds to 29p protein. The present invention further provides methods for delivering an agent into a eukaryotic cell, and methods for causing a eukaryotic cell to secrete a desired protein in the form of a fusion protein. The present invention further provides 29p protein-containing pharmaceutical compositions. The present invention still further provides nucleic acid molecules which hybridize to at least a portion of a nucleic acid molecule encoding 29p protein. Finally, the present invention provides methods for detecting the presence of, and quantitatively determining the amount of, a 29p protein-encoding nucleic acid molecule in a sample.
    Type: Grant
    Filed: January 25, 2001
    Date of Patent: October 26, 2004
    Assignee: The Trustees of Columbia University in the City of New York
    Inventors: Saul J. Silverstein, Paula W. Annuziato, Anne A. Gershon, Octavian Lungu
  • VZV ORF29p protein-related compositions and methods
    Publication number: 20010039051
    Abstract: The present invention provides compositions of matter comprising 29p protein having bound thereto an agent whose delivery into a eukaryotic cell is desired. The present invention also provides a monoclonal antibody which specifically binds to 29p protein. The present invention further provides methods for delivering an agent into a eukaryotic cell, and methods for causing a eukaryotic cell to secrete a desired protein in the form of a fusion protein. The present invention further provides 29p protein-containing pharmaceutical compositions. The present invention still further provides nucleic acid molecules which hybridize to at least a portion of a nucleic acid molecule encoding 29p protein. Finally, the present invention provides methods for detecting the presence of, and quantitatively determining the amount of, a 29p protein-encoding nucleic acid molecule in a sample.
    Type: Application
    Filed: January 25, 2001
    Publication date: November 8, 2001
    Inventors: Saul J. Silverstein, Paula W. Annunziato, Anne A. Gershon, Octavian Lungu
  • Detection of high oncogenic-risk papilloma virus in high grade cervical lesions and cancers by a PCR/ELISA assay
    Patent number: 5888724
    Abstract: This invention provides a method of detecting a high oncogenic-risk type human papillomavirus in a subject which comprises: obtaining from a subject a specimen containing cervical cells and treating the specimen so as to recover nucleic acid molecules present in the cervical cells; contacting the resulting nucleic acid molecules with multiple pairs of single-stranded labeled oligonucleotide primers capable of specifically hybridizing with a different high oncogenic-risk type of human papillomavirus; amplifying any nucleic acid molecules to which a pair of primers hybridizes so as to obtain a double-stranded amplification product and treating any double-stranded amplification product so as to obtain single-stranded nucleic acid molecules; contacting any resulting single-stranded nucleic acid molecules with multiple single-stranded labeled oligonucleotide probes which are capable of specifically hybridizing with such high oncogenic-risk types of human papillomavirus; contacting any resulting hybrids with a mark
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: March 30, 1999
    Assignee: The Trustees of Columbia University in the City of New York
    Inventors: Saul J. Silverstein, Octavian Lungu, Thomas C. Wright, Ralph M. Richart
  • Polymerase chain reaction/restriction fragment polymorphism method for the detection and typing of human papillomaviruses
    Patent number: 5814448
    Abstract: This invention provides a method of typing a human papillomavirus in a patient infected by human papillomavirus which comprises: obtaining a sample containing DNA from the human papillomavirus to be typed; amplifying the L1 portion of the human papillomavirus DNA; treating the resulting amplified DNA with a plurality of predetermined restriction enzymes so as to produce restriction fragments; and analyzing the fragments so produces so as to type the human papillomavirus.
    Type: Grant
    Filed: January 31, 1996
    Date of Patent: September 29, 1998
    Assignee: The Trustees of Columbia University in the City of New York
    Inventors: Saul J. Silverstein, Octavian Lungu, Thomas C. Wright, Jr.
  • Polymerase chain reaction/restriction fragment length polymorphism method for the detection and typing of myobacteria
    Patent number: 5543294
    Abstract: The subject invention provides a method of diagnosing congenital adrenal hyperplasia in a human subject. The subject invention also provides a method of typing a human papillomavirus in a patient infected by a human papillomavirus. The subject invention further provides a method for detecting Mycobacteria in a clinical sample. Finally, the subject invention provides a method for typing Mycobacteria in a clinical sample containing Mycobacteria.
    Type: Grant
    Filed: June 8, 1994
    Date of Patent: August 6, 1996
    Assignee: The Trustees of Columbia University in the City of New York
    Inventors: Saul J. Silverstein, Octavian Lungu, Thomas C. Wright, Jr.