Abstract: The present disclosure concerns mesoporous silica nanoparticles (MSNP) functionalized to cross in and out of cells and loaded with one or more therapeutics to provide a vehicle that can effectively provide localized treatment to both intracellular and extracellular space. The MSNPs provide a vehicle for adjunct treatment of periodontitis, being able to provide treatment against the microbes and to the tissue.

Abstract: An integrated circuit that can include a driver having a first driver output, and a first resistance coupled between a first node coupled to the first driver output and a second node. The first resistance can include a process resistor including a first material having a first temperature coefficient, and an interconnect resistor configured to provide at least 20% of the first resistance and including a second material having a second temperature coefficient which changes resistance in an opposite direction with temperature as compared to the first temperature coefficient. A first terminal of the interconnect resistor is directly connected to a first terminal of the process resistor.

Abstract: An integrated circuit that can include a driver having a first driver output, and a first resistance coupled between a first node coupled to the first driver output and a second node. The first resistance can include a process resistor including a first material having a first temperature coefficient, and an interconnect resistor configured to provide at least 20% of the first resistance and including a second material having a second temperature coefficient which changes resistance in an opposite direction with temperature as compared to the first temperature coefficient. A first terminal of the interconnect resistor is directly connected to a first terminal of the process resistor.

Abstract: A temperature sensor configured to, after a predetermined number of stop counting assertions, determine the temperature dependent voltage and thus the temperature at the output of a counter. During a calibration phase, when a counter value is not equal to a test counter value in a pulse generator circuit, capacitance of the temperature sensor is adjusted until the counter value is equal to the test counter value.

Abstract: A temperature sensor configured to, after a predetermined number of stop counting assertions, determine the temperature dependent voltage and thus the temperature at the output of a counter. During a calibration phase, when a counter value is not equal to a test counter value in a pulse generator circuit, capacitance of the temperature sensor is adjusted until the counter value is equal to the test counter value.

Abstract: A circuit and method for regulating an output voltage are provided. The circuit includes a fully differential first stage amplifier, a second stage amplifier, and a power output driver transistor. The first stage amplifier receives a reference voltage and feedback voltage relative to an output voltage of the power output driver transistor. A differential output of the first stage amplifier is received at differential inputs of the second stage amplifier. The second stage amplifier provides a voltage at a control terminal of the power transistor. The output voltage of the power transistor is based on the voltage at the control terminal and a supply voltage coupled to the power output driver transistor.

Abstract: A circuit and method for regulating an output voltage are provided. The circuit includes a fully differential first stage amplifier, a second stage amplifier, and a power output driver transistor. The first stage amplifier receives a reference voltage and feedback voltage relative to an output voltage of the power output driver transistor. A differential output of the first stage amplifier is received at differential inputs of the second stage amplifier. The second stage amplifier provides a voltage at a control terminal of the power transistor. The output voltage of the power transistor is based on the voltage at the control terminal and a supply voltage coupled to the power output driver transistor.

Abstract: Embodiments of the present invention relate generally to digital volume control in digital audio systems. One embodiment relates to a digital audio system having a digital audio processor and a digital volume control coupled to the digital audio processor. The digital volume control includes a feedback loop having an attenuator, and error determination unit, and a filter. The feedback loop determines the attenuation error and shifts the attenuation error beyond a predetermined digital audio range. The output of the digital volume control maintains a substantially constant SNR and THD with respect to the level attenuation over the predetermined digital audio range.

Abstract: Embodiments of the present invention relate generally to digital volume control in digital audio systems. One embodiment relates to a digital audio system having a digital audio processor and a digital volume control coupled to the digital audio processor. The digital volume control includes a feedback loop having an attenuator, and error determination unit, and a filter. The feedback loop determines the attenuation error and shifts the attenuation error beyond a predetermined digital audio range. The output of the digital volume control maintains a substantially constant SNR and THD with respect to the level attenuation over the predetermined digital audio range.