Patents by Inventor Octavio Ramilo

Octavio Ramilo has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Respiratory syncytial virus having altered NS1 protein function and related materials and methods
    Patent number: 10947512
    Abstract: Embodiments disclosed herein provide compositions, methods, and uses for respiratory syncytial viruses (RSV) and immunogenic compositions thereof. Certain embodiments provide RSV having a mutated NS1 protein, where the mutation causes the uncoupling of the NS1 protein's replication and type I interferon (IFN) antagonist functions. In some embodiments, this uncoupling can produce virions capable of inducing a strong, long-lasting innate immune response while maintaining its ability to replicate in vitro. Also provided are methods for amplifying RSV in host cells, wherein amplified RSV has mutated NS1 protein in which the protein's replication and IFN antagonistic functions are uncoupled. In certain embodiments, the amplified RSV having mutated NS1 protein is formulated into immunogenic compositions, including vaccines. Other embodiments provide methods for inducing an effective immune response against RSV infection in a subject.
    Type: Grant
    Filed: August 12, 2016
    Date of Patent: March 16, 2021
    Assignees: Research Institute at Nationwide Children's Hospital, The University of South Florida
    Inventors: Mark Edward Peeples, Michael Nan-hao Teng, Octavio Ramilo, Maria Asuncion Mejias, Emilio Flano
  • RESPIRATORY SYNCYTIAL VIRUS HAVING ALTERED NS1 PROTEIN FUNCTION AND RELATED MATERIALS AND METHODS
    Publication number: 20190169577
    Abstract: Embodiments disclosed herein provide compositions, methods, and uses for respiratory syncytial viruses (RSV) and immunogenic compositions thereof. Certain embodiments provide RSV having a mutated NS1 protein, where the mutation causes the uncoupling of the NS1 protein's replication and type I interferon (IFN) antagonist functions. In some embodiments, this uncoupling can produce virions capable of inducing a strong, long-lasting innate immune response while maintaining its ability to replicate in vitro. Also provided are methods for amplifying RSV in host cells, wherein amplified RSV has mutated NS1 protein in which the protein's replication and IFN antagonistic functions are uncoupled. In certain embodiments, the amplified RSV having mutated NS1 protein is formulated into immunogenic compositions, including vaccines. Other embodiments provide methods for inducing an effective immune response against RSV infection in a subject.
    Type: Application
    Filed: August 12, 2016
    Publication date: June 6, 2019
    Inventors: Mark Edward PEEPLES, Michael Nan-hao TENG, Octavio RAMILO, Maria Asuncion MEJIAS, Emilio FLANO
  • BIOMARKERS OF KAWASAKI DISEASE
    Publication number: 20140348818
    Abstract: Biomarkers of Kawasaki Disease (KD) are provided. In certain aspects, methods are provided for detecting KD biomarkers, such as elevated PDGFC expression. Likewise, methods of treating a subject having a biomarker of KD are described.
    Type: Application
    Filed: December 21, 2012
    Publication date: November 27, 2014
    Inventors: Virginia M. Pascual, Zhaohui Xu, Octavio Ramilo, Rolando Cimaz
  • Gene Expression Signatures in Blood Leukocytes Permit Differential Diagnosis of Acute Infections
    Publication number: 20080171323
    Abstract: The present invention includes compositions, systems and methods for the early detection and consistent determination of the extent, type and nature of a host immune response and the nature of the infectious disease using gene expression data.
    Type: Application
    Filed: August 10, 2007
    Publication date: July 17, 2008
    Applicants: BAYLOR RESEARCH INSTITUTE, BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
    Inventors: Jacques F. Banchereau, Anna Karolina Palucka, Octavio Ramilo, Damien Chaussabel