Patents by Inventor Octavio Silva
Octavio Silva has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10905452Abstract: The Vertebra Pick Device represents a new instrument to bore pilot holes in vertebra pedicles while imaging the operation with an integrated endoscope. The pilot holes are bored to provide entry points for pedicle screws that serve as anchor points for spine stabilizing rods to treat several spine conditions. The device consists of a metal body that terminates in a tapered incision tip, an endoscope that runs inside said metal body, a handle to drive the device into pedicle boney tissue and a fiber optics bundle assembly that enters the device handle and is used to connect to imaging, illumination, irrigation and suction devices to enable the endoscopic functions of the device. The fiber optics bundle assembly connects to an imaging camera that provides an electrical signal to a monitor to view the operation in real time.Type: GrantFiled: April 19, 2015Date of Patent: February 2, 2021Inventors: Octavio Silva, Fernando Silva
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Patent number: 10626080Abstract: It is provided a process for the preparation of bimatoprost, which comprises: a) reacting a compound of formula (III) with ethylamine in the presence of a suitable solvent; and b) deprotecting compound obtained in step a) to obtain bimatoprost, wherein R1 is selected from (C1-C16)alkyl, (C1C16)haloalkyl, (C2-C16)alkenyl, (C2-C16)haloalkenyl, (C1-C16)alkoxy(C1-C16)alkyl, aryl, (C1-C16)alkylaryl, allyl, —(CH2—CH2—O)n—CH3 wherein n=1, 2, 3 or 4, and —CH(O—CH2—CH2)2; R2 is selected from H, (C1-C16)alkyl, (C1-C16)haloalkyl, (C2-C16)alkenyl, (C2-C16)haloalkenyl, (C1-C16)alkoxy(CrC16)alkyl, aryl, (C1-C16)alkylaryl, allyl; or, alternatively, R1 and R2 taken together are selected from —CH2—CH2—CH2—, —CH2—CH2—, —O—CH2—CH2—, and —O—CH?CH—. There are also provided intermediates useful in such preparation process.Type: GrantFiled: April 18, 2017Date of Patent: April 21, 2020Assignee: GENTEC, S.A.Inventors: Luis Octavio Silva Guisasola, Joaquín Nebot Troyano, Jordi Ripoll Altadill
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Publication number: 20200010406Abstract: It is provided a process for the preparation of bimatoprost, which comprises: a) reacting a compound of formula (III) with ethylamine in the presence of a suitable solvent; and b) deprotecting compound obtained in step a) to obtain bimatoprost, wherein R1 is selected from (C1-C16)alkyl, (C1C16)haloalkyl, (C2-C16)alkenyl, (C2-C16)haloalkenyl, (C1-C16)alkoxy(C1-C16)alkyl, aryl, (C1-C16)alkylaryl, allyl, —(CH2—CH2—O)n—CH3 wherein n=1, 2, 3 or 4, and —CH(O—CH2—CH2)2; R2 is selected from H, (C1-C16)alkyl, (C1-C16)haloalkyl, (C2-C16)alkenyl, (C2-C16)haloalkenyl, (C1-C16)alkoxy(CrC16)alkyl, aryl, (C1-C16)alkylaryl, allyl; or, alternatively, R1 and R2 taken together are selected from —CH2—CH2—CH2—, —CH2—CH2—, —O—CH2—CH2—, and —O—CH?CH—. There are also provided intermediates useful in such preparation process.Type: ApplicationFiled: April 18, 2017Publication date: January 9, 2020Inventors: Luis Octavio SILVA GUISASOLA, Joaquín NEBOT TROYANO, Jordi RIPOLL ALTADILL
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Patent number: 9000195Abstract: Olopatadine can be obtained by means of a process comprising hydrolysis of a compound of general formula (II), wherein Y is OR1, wherein R1 is C1-C7 alkyl, C3-C7 cycloalkyl, aryl, arylalkyl, or heterocycle; or NR2R3, wherein R2 and R3, independently from each other, are C1-C7 alkyl, aryl, arylalkyl, or R2 and R3 together with the nitrogen atom to which they are bound form a heterocycle of 3 to 7 members, obtained by means of a process comprising reacting the corresponding ester or amide of 6,11-dihydro-11-oxodibenz[b,e]oxepin-2-acetic acid with a suitable Wittig reagent, in the presence of a base in a reaction medium comprising an organic solvent.Type: GrantFiled: July 14, 2009Date of Patent: April 7, 2015Assignee: Crystal Pharma, S.A.U.Inventors: Luis Octavio Silva Guisasola, Lydia Mateos Burón, Antonio Lorente Bonde-Larsen, Luis Gerardo Gutiérrez Fuentes
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Patent number: 8952173Abstract: The invention relates to a novel method for the resolution of the racemic mixture of compound (R,S)-2-amino-6-propylamino-4,5,6,7-tetrahydrobenzothiazole, or the enrichment of same with in one of its enantiomers, and to intermediate compounds which can be used to perform said method.Type: GrantFiled: May 9, 2006Date of Patent: February 10, 2015Assignee: Crystal Pharma, S.A.U.Inventors: Luis Octavio Silva Guisasola, Jorge Martin Juarez
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Publication number: 20130201277Abstract: ViSTORE is a video teleconferencing system used with networked devices and is capable of storing all or parts of video conferencing sessions on demand that can be played back at a later time. The system consists of a web portal, where all multimedia data is stored, and a software application hosted in the networked devices. The networked devices can be any wired or wireless devices such as laptops and smart phones. The system is capable of hosting multiple videoconferencing parties and each user is capable of storing any part of a given user video session. The system also can play concurrently video feeds, such as a live TV channel, or video clips, such as those of news websites. In addition, the system can display simultaneously multimedia such as photos and images. Finally, the system allows user to create and display notes and MS Office applications files.Type: ApplicationFiled: May 31, 2012Publication date: August 8, 2013Inventor: Octavio Silva
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Publication number: 20120004426Abstract: Olopatadine can be obtained by means of a process comprising hydrolysis of a compound of general formula (II), wherein Y is OR1, wherein R1 is C1-C7 alkyl, C3-C7 cycloalkyl, aryl, arylalkyl, or heterocycle; or NR2R3, wherein R2 and R3, independently from each other, are C1-C7 alkyl, aryl, arylalkyl, or R2 and R3 together with the nitrogen atom to which they are bound form a heterocycle of 3 to 7 members, obtained by means of a process comprising reacting the corresponding ester or amide of 6,11-dihydro-11-oxodibenz[b,e]oxepin-2-acetic acid with a suitable Wittig reagent, in the presence of a base in a reaction medium comprising an organic solvent.Type: ApplicationFiled: July 14, 2009Publication date: January 5, 2012Applicant: RAGACTIVES, S.L.U.Inventors: Luis Octavio Silva Guisasola, Lydia Mateos Burón, Antonio Lorente Bonde-Larsen, Luis Gerardo Gutiérrez Fuentes
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Patent number: 7842821Abstract: The invention is aimed at a compound of formula (I) wherein n is 0, 1 or 2, R1 is a linear or branched alkyl group, R2 is selected from a substituted or non substituted alkyl group, substituted or non substituted aryl group, substituted or non substituted aralkyl group, substituted or non substituted heterocyclyl group, or a substituted or non substituted heterocyclylalkyl group. Another object of the invention is a process for obtaining these compounds from the corresponding compound with a hydroxy group in position 4 by means of reacting with a sulfonamide in the presence of a phosphine and a dialkyl azadicarboxylate. The deprotection of the compound of formula (I) gives rise to the corresponding amine. The intermediate and the processes described are very useful in the synthesis of pharmaceutical products.Type: GrantFiled: November 4, 2005Date of Patent: November 30, 2010Assignee: Ragactives, S.L.Inventors: José María Gorgojo Lobato, Luis Octavio Silva Guisasola, Jorge Martín Juárez
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Patent number: 7795435Abstract: The process includes the steps of (i) dissolving finasteride in a substantially anhydrous organic solvent selected among n-butyl acetate, iso-butyl acetate, sec-butyl acetate, tert-butyl acetate, C5 alkyl acetate and mixtures thereof, at a temperature equal to or lower than the boiling point of said organic solvent; (ii) slowly cooling said finasteride solution to a cooling temperature determined on the basis of the chosen solvent; (iii) maintaining the resulting suspension at the cooling temperature for a period of time equal to or less than 16 hours; and (iv) recovering the resulting solid phase containing Form I of finasteride, for example by means of filtration, and removing the solvent, for example by means of drying said crystals. The process allows for obtaining the Form I of finasteride only and in a pure form.Type: GrantFiled: April 29, 2005Date of Patent: September 14, 2010Assignee: Ragactives, S.L.Inventors: Luis Octavio Silva Guisasola, Mario Laderas Muñoz, Jorge Martin Juarez
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Publication number: 20090076287Abstract: The invention is aimed at a compound of formula (I) wherein n is 0, 1 or 2, R1 is a linear or branched alkyl group, R2 is selected from a substituted or non substituted alkyl group, substituted or non substituted aryl group, substituted or non substituted aralkyl group, substituted or non substituted heterocyclyl group, or a substituted or non substituted heterocyclylalkyl group. Another object of the invention is a process for obtaining these compounds from the corresponding compound with a hydroxy group in position 4 by means of reacting with a sulfonamide in the presence of a phosphine and a dialkyl azadicarboxylate. The deprotection of the compound of formula (I) gives rise to the corresponding amine. The intermediate and the processes described are very useful in the synthesis of pharmaceutical products.Type: ApplicationFiled: November 4, 2005Publication date: March 19, 2009Applicant: RAGACTIVES, S.L.Inventors: Jose Maria Gorgojo Lobato, Luis Octavio Silva Guisasola, Jorge Martin Juarez
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Publication number: 20080194832Abstract: The invention relates to a novel method for the resolution of the racemic mixture of compound (R,S)-2-amino-6-propylamino-4,5,6,7-tetrahydrobenzothiazole, or the enrichment of same with in one of its enantiomers, and to intermediate compounds which can be used to perform said method.Type: ApplicationFiled: May 9, 2006Publication date: August 14, 2008Applicant: Ragactives, S.L.Inventors: Luis Octavio Silva Guisasola, Jorge Martin Juarez
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Patent number: 7105698Abstract: The process for separating the R(?)- and S(+)-5-[2-[[2-(2-ethoxyphenoxy)ethyl]amino]propyl]-2-methoxybenzene-sulfonamide enantiomers comprises (a) reacting a mixture of said enantiomers with an optically active organic acid to form diastereoisomeric salts with said enantiomers, where in said diastereoisomeric salts have different solubility and can be separated by crystallization; (b) separating the diastereoisomeric salt mixture enriched in the salt of one of the enantiomers; and (c) releasing said salts to obtain the R(?)or S(+) enantiomer. The R(?)-5-[2-[[2-(2-ethoxyphenoxy) ethyl]amino]propyl]-2-methoxybenzenesulfonamide enantiomer has ?-adrenergic blocking activity and is useful as an antihypertensive agent suitable for the treatment of congestive heart failure and benign prostatic hypertrophy.Type: GrantFiled: March 12, 2004Date of Patent: September 12, 2006Assignee: Ragactives, S.L.Inventors: Cristina Blanco Fernandez, Antonio Lorente Bonde-Larsen, Jorge Martin Juarez, Luis Octavio Silva Guisasola
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Patent number: 7030250Abstract: The process for obtaining 4-(N-alkylamino)-5,6-dihydro-4H-thien-(2,3-b)-thiopyran-2-sulfonamide-7,7-dioxides (I) wherein R1 is H or C1-5 alkyl, and R2 is C1-5 alkyl, starts from the corresponding 4-(N-alkylamino)-5,6-dihydro-4H-thien-(2,3-b)-thiopyran-7,7-dioxides, and comprises protecting the alkylamine group, introducing a sulfonamide group and eliminating protecting group.Type: GrantFiled: March 3, 2003Date of Patent: April 18, 2006Assignee: Ragatives, S.L.Inventors: Pablo García Losada, Luis Octavio Silva Guisasola, Antonio Lorente Bonde-Larsen, Jorge Martín Juárez
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Publication number: 20040181055Abstract: 6&agr;-fluorpregnanes (I), where the dotted line between positions 1 and 2 represents a single or double bond; R1 is OH, OCOR2, X, SO3R3, or an (R7)(R8)(R9)SiO— group, where X is halogen, R2 and R3 are C1-6 alkyl or phenyl optionally substituted by C1-4 alkyl, and R7, R8 and R9, equal or different, are C1-6 alkyl or phenyl optionally substituted by C1-4 alkyl, can be obtained by means of a high stereoselectivity process comprising reacting a 3-(trisubstituted)silyloxy-pregna-3,5-diene (IV) with a fluorinating agent selected among N-fluorosulfonimides and N-fluorosulfonamides. The 6&agr;-fluorpregnanes (I) are intermediates for the synthesis of steroids useful as anti-inflammatory and anti-asthmatic agents.Type: ApplicationFiled: January 26, 2004Publication date: September 16, 2004Applicant: Ragactives, S.L.Inventors: Jose Vicente Murillo Garrido, Luis Octavio Silva Guisasola, Jorge Martin Juarez
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Publication number: 20030220509Abstract: The process for obtaining 4-(N-alkylamino)-5,6-dihydro-4H-thien-(2,3-b)-thiopyran-2-sulfonamide-7,7-dioxides (I) wherein R1 is H or C1-5 alkyl, and R2 is C1-5 alkyl, starts from the corresponding 4-(N-alkylamino)-5,6-dihydro-4H-thien-(2,3-b)-thiopyran-7,7-dioxides, and comprises protecting the alkylamine group, introducing a sulfonamide group and eliminating protecting group. Some compounds of formula (I) are inhibitors of the carbonic anhydrase and can be used in the treatment of elevated intraocular pressure.Type: ApplicationFiled: March 3, 2003Publication date: November 27, 2003Applicant: RAGACTIVES, S.L.Inventors: Pablo Garcia Losada, Luis Octavio Silva Guisasola, Antonio Lorente Bonde-Larsen, Jorge Martin Juarez
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Patent number: 6509466Abstract: 17&bgr;-(N-tert-butylcarbamoyl)-3-one-4-aza-steroids (I) can be obtained by a process which comprises the reaction of 17&bgr;-(alkoxycarbonyl)-3-one-4-aza-steroid with lithium tert-butylamide in an organic solvent. Some compounds of formula (I), for example, finasteride, are useful as inhibitors of 5&agr;-reductase, and can be used in the treatment of benign prostatic hyperplasia and alopecia.Type: GrantFiled: March 5, 2001Date of Patent: January 21, 2003Assignee: Raga Consultores, S.L.Inventors: Luis Octavio Silva Guisasola, Cristina Blanco Fernandez, Antonio Lorente Bonde-Larsen, Jorge Martin Juarez
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Publication number: 20010008895Abstract: 17&bgr;-(N-tert-butylcarbamoyl)-3-one-4-aza-steroids (I) can be obtained by a process which comprises the reaction of 17&bgr;-(alkoxycarbonyl)-3-one-4-aza-steroid with lithium tert-butylamide in an organic solvent. Some compounds of formula (I), for example, finasteride, are useful as inhibitors of 5&agr;-reductase, and can be used in the treatment of benign prostatic hyperplasia and alopecia.Type: ApplicationFiled: March 5, 2001Publication date: July 19, 2001Applicant: Raga Consultores, S.L.Inventors: Luis Octavio Silva Guisasola, Cristina Blanco Fernandez, Antonio Lorente Bonde-Larsen, Jorge Martin Juarez