Patents by Inventor Odelya E. Pagovich

Odelya E. Pagovich has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods of Treating Food Allergy by Administering an IL-4R Antagonist and a BCMA Targeting Agent
    Publication number: 20260201051
    Abstract: Methods for treating a subject having an IgE-mediated allergy or for preventing or reducing the severity of an allergic reaction in a subject having an IgE-mediated allergy are provided. In one aspect, the methods comprise administering to a subject having an IgE-mediated allergy an IL-4R antagonist, such as an IL-4R? antibody, and a BCMA targeting agent, such as a BCMA x CD3 bispecific antibody.
    Type: Application
    Filed: January 9, 2026
    Publication date: July 16, 2026
    Inventors: Andre Limnander, Jennifer Maloney, Andrew J. Murphy, Jamie M. Orengo, Odelya E. Pagovich, Allen Radin, George D. Yancopoulos
  • Gene therapy for eosinophilic disorders
    Patent number: 12226492
    Abstract: Compositions and methods for eosinophilia in a mammal are provided. In one embodiment, the composition is a viral gene therapy vector, and a single dose of the vector reduces increased numbers of eosinophils in a mammal.
    Type: Grant
    Filed: December 28, 2018
    Date of Patent: February 18, 2025
    Assignee: Cornell University
    Inventors: Ronald G. Crystal, Odelya E. Pagovich, Katie Stiles
  • GENE THERAPY FOR THE TREATMENT OF ALDEHYDE DEHYDROGENASE DEFICIENCY
    Publication number: 20190160187
    Abstract: A vector comprising a promoter operably linked to a nucleic acid sequence encoding human aldehyde dehydrogenase, as well as a composition comprising the vector and method of using the vector to treat aldehyde dehydrogenase deficiency, or to prevent or treat a disease characterized by aldehyde dehydrogenase deficiency.
    Type: Application
    Filed: July 26, 2017
    Publication date: May 30, 2019
    Applicants: Cornell University, Adverum Biotechnologies, Inc.
    Inventors: Mehdi Gasmi, Ronald G. Crystal, Odelya E. Pagovich
  • Gene therapy to prevent reactions to allergens
    Patent number: 10293059
    Abstract: This invention is directed to a vector which comprises a promoter operably linked to a nucleic acid sequence encoding a therapeutic gene that blocks allergic reactions. The invention is also directed to a composition comprising the vector and method of using the vector to reduce or inhibit an immune response or allergic reaction to an allergen in a mammal.
    Type: Grant
    Filed: April 11, 2016
    Date of Patent: May 21, 2019
    Assignee: CORNELL UNIVERSITY
    Inventors: Ronald G. Crystal, Odelya E. Pagovich, Maria J. Chiuchiolo
  • ADENO-ASSOCIATED VIRUS MEDIATED DELIVERY OF C1EI AS A THERAPY FOR ANGIOEDEMA
    Publication number: 20190119653
    Abstract: This invention is directed to a vector which comprises a promoter operably linked to a nucleic acid sequence encoding the human C1 esterase inhibitor or Factor XII. The invention is also directed to a composition comprising the vector and a method of using the vector to treat or prevent hereditary angioedema.
    Type: Application
    Filed: January 4, 2019
    Publication date: April 25, 2019
    Inventors: Ronald G. Crystal, Odelya E. Pagovich, Maria J. Chiuchiolo
  • Adeno-associated virus mediated delivery of C1E1 as a therapy for angioedema
    Patent number: 10214731
    Abstract: This invention is directed to a vector which comprises a promoter operably linked to a nucleic acid sequence encoding the human C1 esterase inhibitor or Factor XII. The invention is also directed to a composition comprising the vector and a method of using the vector to treat or prevent hereditary angioedema.
    Type: Grant
    Filed: May 27, 2016
    Date of Patent: February 26, 2019
    Assignee: CORNELL UNIVERSITY
    Inventors: Ronald G. Crystal, Odelya E. Pagovich, Maria J. Chiuchiolo
  • ADENO-ASSOCIATED VIRUS MEDIATED DELIVERY OF C1EI AS A THERAPY FOR ANGIOEDEMA
    Publication number: 20160347822
    Abstract: This invention is directed to a vector which comprises a promoter operably linked to a nucleic acid sequence encoding the human C1 esterase inhibitor or Factor XII. The invention is also directed to a composition comprising the vector and a method of using the vector to treat or prevent hereditary angioedema.
    Type: Application
    Filed: May 27, 2016
    Publication date: December 1, 2016
    Inventors: Ronald G. Crystal, Odelya E. Pagovich, Maria J. Chiuchiolo
  • GENE THERAPY TO PREVENT REACTIONS TO ALLERGENS
    Publication number: 20160296638
    Abstract: This invention is directed to a vector which comprises a promoter operably linked to a nucleic acid sequence encoding a therapeutic gene that blocks allergic reactions. The invention is also directed to a composition comprising the vector and method of using the vector to reduce or inhibit an immune response or allergic reaction to an allergen in a mammal.
    Type: Application
    Filed: April 11, 2016
    Publication date: October 13, 2016
    Inventors: Ronald G. Crystal, Odelya E. Pagovich, Maria J. Chiuchiolo