Patents by Inventor Odile Puijalon

Odile Puijalon has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Molecular marker of plasmodium falciparum artemisinin resistance
    Patent number: 11732312
    Abstract: K13-propeller polymorphism is a useful molecular marker for tracking the emergence and spread of ART-resistant P. falciparum. The invention encompasses methods, compositions, and kits for detecting and genotyping Plasmodium, for example, Plasmodium falciparum. The methods, compositions, and kits can be used to detect the presence or absence of a mutated K-13 propeller nucleic acid or protein in the sample.
    Type: Grant
    Filed: December 16, 2020
    Date of Patent: August 22, 2023
    Assignees: INSTITUT PASTEUR, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, INSTITUT PASTEUR DU CAMBODGE
    Inventors: Frederic Ariey, Odile Puijalon, Didier Menard, Francoise Benoit-Vical, Johann Beghain, Benoit Witkowski, Jean-Christophe Barale, Christiane Bouchier, Nimol Khim
  • MOLECULAR MARKER OF PLASMODIUM FALCIPARUM ARTEMISININ RESISTANCE
    Publication number: 20210198755
    Abstract: K13-propeller polymorphism is a useful molecular marker for tracking the emergence and spread of ART-resistant P. falciparum. The invention encompasses methods, compositions, and kits for detecting and genotyping Plasmodium, for example, Plasmodium falciparum. The methods, compositions, and kits can be used to detect the presence or absence of a mutated K-13 propeller nucleic acid or protein in the sample.
    Type: Application
    Filed: December 16, 2020
    Publication date: July 1, 2021
    Inventors: Frederic ARIEY, Odile PUIJALON, Didier MENARD, Francoise BENOIT-VICAL, Johann BEGHAIN, Benoit WITKOWSKI, Jean-Christophe BARALE, Christiane BOUCHIER, Nimol KHIM
  • Molecular marker of plasmodium falciparum artemisinin resistance
    Patent number: 10900093
    Abstract: K13-propeller polymorphism is a useful molecular marker for tracking the emergence and spread of ART-resistant P. falciparum. The invention encompasses methods, compositions, and kits for detecting and genotyping Plasmodium, for example, Plasmodium falciparum. The methods, compositions, and kits can be used to detect the presence or absence of a mutated K-13 propeller nucleic acid or protein in the sample.
    Type: Grant
    Filed: November 14, 2014
    Date of Patent: January 26, 2021
    Assignees: INSTITUT PASTEUR, INSTITUT PASTEUR DU CAMBODGE, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
    Inventors: Frederic Ariey, Odile Puijalon, Didier Menard, Francoise Benoit-Vical, Johann Beghain, Benoit Witkowski, Jean-Christophe Barale, Christiane Bouchier, Nimol Khim
  • A MOLECULAR MARKER OF PLASMODIUM FALCIPARUM ARTEMISININ RESISTANCE
    Publication number: 20160289774
    Abstract: K13-propeller polymorphism is a useful molecular marker for tracking the emergence and spread of ART-resistant P. falciparum. The invention encompasses methods, compositions, and kits for detecting and genotyping Plasmodium, for example, Plasmodium falciparum. The methods, compositions, and kits can be used to detect the presence or absence of a mutated K-13 propeller nucleic acid or protein in the sample.
    Type: Application
    Filed: November 14, 2014
    Publication date: October 6, 2016
    Inventors: Frederic ARIEY, Odile PUIJALON, Didier MENARD, Francoise BENOIT-VICAL, Johann BEGHAIN, Benoit WITKOWSKI, Jean-Christophe BARALE, Christiane BOUCHIER, Nimol KHIM
  • Screening methods for identifying proteases inhibitors
    Patent number: 9404142
    Abstract: The invention relates to the field of parasitology. Methods and peptidic substrate for screening and identifying inhibitors of Plasmodium are described. Also described are compounds identified by these screening methods, including more particularly inhibitors of Plasmodium subtilisin-like proteases. The invention also concerns anti-malaria compounds, anti-malaria compositions, and uses thereof for preventing, treating, improving, and/or alleviating a Plasmodium infection in a subject, and more Plasmodium vivax and/or by Plasmodium falciparum human infections.
    Type: Grant
    Filed: November 29, 2010
    Date of Patent: August 2, 2016
    Assignee: Institut Pasteur
    Inventors: Jean-Christophe Barale, Anthony Bouillon, David Giganti, Olivier Louis Gabiel Gorgette, Veronique Stoven, Michael Nilges, Odile Puijalon
  • SCREENING METHODS FOR IDENTIFYING PLASMODIUM PROTEASES INHIBITORS
    Publication number: 20140134657
    Abstract: The invention relates to the field of parasitology. Methods and peptidic substrate for screening and identifying inhibitors of Plasmodium are described. Also described are compounds identified by these screening methods, including more particularly inhibitors of Plasmodium subtilisin-like proteases. The invention also concerns anti-malaria compounds, anti-malaria compositions, and uses thereof for preventing, treating, improving, and/or alleviating a Plasmodium infection in a subject, and more Plasmodium vivax and/or by Plasmodium falciparum human infections.
    Type: Application
    Filed: November 29, 2010
    Publication date: May 15, 2014
    Inventors: Jean-Christophe Barale, Anthony Bouillon, Olivier Louis Gabriel Gorgette, David Giganti, Véronique Stoven, Michael Nilges, Odile Puijalon
  • METHOD FOR SCREENING COMPOUNDS FOR THEIR ABILITY TO INCREASE RIGIDITY OF RED BLOOD CELLS INFECTED BY A PROTOZOAN PARASITE OF THE GENUS PLASMODIUM, METHOD FOR FILTERING RED BLOOD CELLS, AND APPLICATION THEREOF
    Publication number: 20110230369
    Abstract: The invention relates to a method for screening compounds for their ability to increase rigidity of red blood cells (RBCs) infected by a protozoan parasite of the genus Plasmodium and in particular by Plasmodium falciparum. The present invention also relates to a method for filtering RBCs that enables retention, in a filtering unit, of RBCs having an abnormal and in particular a decreased deformability, as a surrogate for spleen filtering function. Said method enables in particular isolating and/or detecting Plasmodium-infected RBCs or spherocytes associated with acquired or hereditary spherocytosis from a sample of blood from a patient, or analysing in vitro spleen function of a patient.
    Type: Application
    Filed: May 28, 2009
    Publication date: September 22, 2011
    Inventors: Pierre Antoine Buffet, Guillaume Deplaine, Gencvièvc Milon, Peter David, Innocent Safeukui Noubissi, Sylvie Perrot, Valentine Brousse, Narla Mohandas, Francois Lacoste, Odile Puijalon
  • Molecules containing at least one peptide sequence carrying one or several epitopes characteristic of a protein produced by P. falciparum in hepatocytes and compositions containing them
    Patent number: 5928901
    Abstract: The invention relates to a molecule comprising one or more peptide sequences of formula:Leu-Ala-Lys-Glu-Lys-Leu-Gln-X-Gln-Gln-Ser-Asp-Leu- Glu-Gln-Glu-Argin which X is Glu or Gly. It also relates to the utilisation of these molecules in assays and in vitro diagnostic kits for malaria on a biological sample derived from the individual in whom the disease is to be detected.
    Type: Grant
    Filed: December 3, 1996
    Date of Patent: July 27, 1999
    Assignee: Institut Pasteur
    Inventors: Claudine Marchand, Pierre Druilhe, Odile Puijalon-Mercereau, Gordon Langsley
  • DNA encoding molecules containing at least one peptide sequence carrying one or several epitopes characteristic of a liver stage antigen produced by p. falciparum in hepatocytes and compositions containing them
    Patent number: 5602031
    Abstract: The invention relates to a molecule comprising one or more peptide sequences of formula:Leu-Ala-Lys-Glu-Lys-Leu-Gln-X-Gln-Gln-Ser-Asp-Leu-Glu-Gln-Glu-Argin which X is Glu or Gly.It also relates to the utilisation of these molecules in assays and in vitro diagnostic kits for malaria on a biological sample derived from the individual in whom the disease is to be detected.
    Type: Grant
    Filed: June 5, 1995
    Date of Patent: February 11, 1997
    Assignee: Institut Pasteur
    Inventors: Claudine Marchand, Pierre Druilhe, Odile Puijalon-Mercereau, Gordon Langsley
  • Molecules containing at least one peptide sequence carrying one or several epitopes characteristic of a liver stage antigen produced by P. falciparum in hepatocytes and compositions containing them
    Patent number: 5599542
    Abstract: The invention relates to a molecule comprising one or more peptide sequences of formula:Leu-Ala-Lys-Glu-Lys-Leu-Gln-X-Gln-Gln-Ser-Asp-Leu-Glu-Gln-Glu-Argin which X is Glu or Gly.It also relates to the utilization of these molecules in assays and in vitro diagnostic kits for malaria on a biological sample derived from the individual in whom the disease is to be detected.
    Type: Grant
    Filed: October 6, 1988
    Date of Patent: February 4, 1997
    Assignee: Institut Pasteur
    Inventors: Claudine Marchand, Pierre Druilhe, Odile Puijalon-Mercereau, Gordon Langsley
  • Antibodies which bind to molecules containing at least one peptide sequence carrying one or several epitopes characteristic of a liver stage antigen produced by P. falciparum in hepatocytes
    Patent number: 5589343
    Abstract: The invention relates to a molecule comprising one or more peptide sequences of formula:Leu-Ala-Lys-Glu-Lys-Leu-Gln-X-Gln-Gln-Ser-Asp-Leu-Glu-Gln-Glu-Argin which X is Glu or Gly.It also relates to the utilisation of these molecules in assays in vitro diagnostic kits for malaria on a biological sample derived from the individual in whom the disease is to be detected.
    Type: Grant
    Filed: June 5, 1995
    Date of Patent: December 31, 1996
    Assignee: Institut Pasteur
    Inventors: Claudine Marchand, Pierre Druilhe, Odile Puijalon-Mercereau, Gordon Langsley