Abstract: An ocular implant includes an endothelial patch constructed of a clear, transparent, biologically compatible material, and which has a property-modified region that has different properties than other portions of the endothelial patch.

Abstract: An ocular implant includes an endothelial protective implant which is dome-shaped and constructed of a clear, transparent, biologically compatible material, and a grasping member that extends outwards from a periphery of the endothelial protective implant.

Abstract: A method is described of improving adhesion of an ocular implant to corneal tissue by forming an implant adhesive layer on the ocular implant, the implant adhesive layer having greater adhesive strength than a rest of the implant or by forming a corneal adhesive layer on a posterior surface of a posterior portion of the corneal tissue, the corneal adhesive layer having greater adhesive strength than a rest of the corneal tissue.

Abstract: A corneal implant (10) includes a central portion (12) and a peripheral skirt (14) extending outwards from the central portion (12), and at least a portion of the peripheral skirt (14) includes a mesh (16).

Abstract: An ocular implant is constructed of a clear, transparent, biologically compatible material and includes a hydrophilic outer surface configured for continuous attachment to a posterior surface of a cornea. The ocular implant has a first radius of curvature at initial attachment to the posterior surface of the cornea and a second radius of curvature at post-initial attachment to the posterior surface of the cornea. The first radius of curvature is different than the second radius of curvature. The ocular implant remains attached to the posterior surface of the cornea at both the first and second radii of curvature.

Abstract: A corneal implant injector system includes an injector including a plunger slidable in a plunger housing, and a distal cartridge grabbing member engageable with an implant-holding cartridge.

Abstract: An ocular implant is constructed of a clear, transparent, biologically compatible material and includes a hydrophilic outer surface configured for continuous attachment to a posterior surface of a cornea. The ocular implant has a first radius of curvature at initial attachment to the posterior surface of the cornea and a second radius of curvature at post-initial attachment to the posterior surface of the cornea. The first radius of curvature is different than the second radius of curvature. The ocular implant remains attached to the posterior surface of the cornea at both the first and second radii of curvature.

Abstract: A corneal implant (10) includes a central portion (12) and a peripheral skirt (14) extending outwards from the central portion (12), and at least a portion of the peripheral skirt (14) includes a mesh (16).

Abstract: A corneal implant injector system includes an injector including a plunger slidable in a plunger housing, and a distal cartridge grabbing member engageable with an implant-holding cartridge.

Abstract: A method is described of improving adhesion of an ocular implant to corneal tissue by forming an implant adhesive layer on the ocular implant, the implant adhesive layer having greater adhesive strength than a rest of the implant or by forming a corneal adhesive layer on a posterior surface of a posterior portion of the corneal tissue, the corneal adhesive layer having greater adhesive strength than a rest of the corneal tissue.

Abstract: A method includes placing a contact lens over a cornea of an eye. The contact lens includes a central convex disc, a peripheral curved portion that extends radially from the disc, an annular groove formed in the disc on the posterior portion, and one or more apertures formed in the groove. A drug substance is placed over the anterior portion of the contact lens. The groove is in contact with the cornea and is a depot for the drug substance. The groove is in fluid connection with the anterior portion of the lens via the one or more apertures. The drug substance moves in an undiluted manner to the groove and the contact lens holds the drug substance in contact with the cornea, unaffected by blinking or tear exchange, facilitating enhanced bioavailability to the cornea of the drug substance.

Abstract: A method is described of improving adhesion of an ocular implant to corneal tissue by forming an implant adhesive layer on the ocular implant, the implant adhesive layer having greater adhesive strength than a rest of the implant or by forming a corneal adhesive layer on a posterior surface of a posterior portion of the corneal tissue, the corneal adhesive layer having greater adhesive strength than a rest of the corneal tissue.

Abstract: A method is described of improving adhesion of an ocular implant to corneal tissue by forming an implant adhesive layer on the ocular implant, the implant adhesive layer having greater adhesive strength than a rest of the implant or by forming a corneal adhesive layer on a posterior surface of a posterior portion of the corneal tissue, the corneal adhesive layer having greater adhesive strength than a rest of the corneal tissue.

Abstract: A method is described of improving adhesion of an ocular implant to corneal tissue by forming an implant adhesive layer on the ocular implant, the implant adhesive layer having greater adhesive strength than a rest of the implant or by forming a corneal adhesive layer on a posterior surface of a posterior portion of the corneal tissue, the corneal adhesive layer having greater adhesive strength than a rest of the corneal tissue.

Abstract: A corneal implant includes a central portion and a peripheral skirt extending outwards from the central portion, and at least a portion of the peripheral skirt includes a mesh.

Abstract: A method is described of improving adhesion of an ocular implant to corneal tissue by forming an implant adhesive layer on the ocular implant, the implant adhesive layer having greater adhesive strength than a rest of the implant or by forming a corneal adhesive layer on a posterior surface of a posterior portion of the corneal tissue, the corneal adhesive layer having greater adhesive strength than a rest of the corneal tissue.

Abstract: A method includes placing a contact lens over a cornea of an eye. The contact lens includes a central convex disc, a peripheral curved portion that extends radially from the disc, an annular groove formed in the disc on the posterior portion, and one or more apertures formed in the groove. A drug substance is placed over the anterior portion of the contact lens. The groove is in contact with the cornea and is a depot for the drug substance. The groove is in fluid connection with the anterior portion of the lens via the one or more apertures. The drug substance moves in an undiluted manner to the groove and the contact lens holds the drug substance in contact with the cornea, unaffected by blinking or tear exchange, facilitating enhanced bioavailability to the cornea of the drug substance.

Abstract: A hyper-osmotic contact lens including a contact lens including a central convex disc, a peripheral curved portion that extends radially from the disc, an annular groove formed in the disc and one or more apertures formed in the groove.

Abstract: A keratoprosthesis includes an anterior collagen layer made of transparent synthetic collagen, and a hydrophobic posterior layer, an anterior surface of the posterior layer being posterior of an anterior surface of the collagen layer.

Abstract: A method for drug delivery includes placing a contact lens over a cornea of an eye. The contact lens includes a central convex disc, a peripheral curved portion that extends radially from the disc, an annular groove formed in the disc, and one or more apertures formed in the groove. An inner volume of the lens defines a chamber. A drug substance is placed in the chamber, which traps the drug substance therein for a period of time.