Abstract: Embodiments of the present disclosure are directed to blood-flow regulation systems and associated methods, and, in some embodiments, includes an adjustable blood flow regulation device that includes an inner tube, an expandable member coupled to the inner tube, a proximal control handle that includes a controller operatively coupled to the member and configured to control expansion of the member, and a downstream tip member coupled to a distal portion of the inner tube which is distal to the member. The tip member is coupled to a first fluid pressure sensor. A second fluid pressure sensor is coupled to a portion of the inner tube proximal to the member.