Abstract: An expandable clot mobilizer device for extraction of an occlusion from a blood vessel is provided, which comprises a working portion including a plurality of crowns of cells. Each cell comprises an open area bordered by two proximal cell struts, two distal cell struts, and two middle cell struts. The proximal cell struts each extending distally from a common proximal end to a proximal end of a respective one of the two middle cell struts, the distal cell struts each extending proximally from a common distal end to a distal end of a respective one of the two middle cell struts, each middle cell strut in each crown bordering two adjacent cells in that crown and each middle cell strut being adapted and configured to be more flexible than the distal cell strut and the proximal cell strut to which it extends. The clot mobilizer also comprises a tapered portion.

Abstract: A self-expandable medical device for advancement through vasculature to an expansion site in a blood vessel is disclosed. The device comprises a working portion and a connection portion that can be connected to a pusher. The working portion provides an outward radial force at every diameter between and including the diameter of a compressed and an expanded configurations, and comprises a plurality of crowns of cells comprising an open area bordered by two proximal cell struts, two distal cell struts, and two middle cell struts. The proximal cell struts each extend distally from a common proximal end to a proximal end of a respective one of the two middle cell struts. The distal cell struts each extend proximally from a common distal end to a distal end of a respective one of the two middle cell struts. Each middle cell strut is more flexible than the distal cell strut and proximal cell strut to which it extends.

Abstract: A method of extracting a thrombus from a thrombus site in a cerebral artery of a patient by advancing a first catheter into an internal carotid artery of the patient; advancing a funnel catheter within the first catheter; moving the funnel catheter and the first catheter with respect to each other to place the funnel outside of the first catheter; expanding the funnel into contact with an inner wall of the internal carotid artery at or proximal to a distal end of a carotid siphon, thereby reducing blood flow past the funnel; advancing a clot-mobilizer distally through the first catheter toward the thrombus and beyond the carotid siphon; engaging thrombus material from the thrombus with the clot-mobilizer; moving the clot-mobilizer and thrombus material proximally at least partially into the funnel; applying suction to aspirate thrombus material; and moving the funnel, the clot-mobilizer and the thrombus material proximally within the vasculature.

Abstract: A clot mobilizer device for extraction of an occlusion from a blood vessel is provided, which comprises a working portion including a plurality of crowns of cells. Each cell comprises an open area bordered by struts. A distal end of each cell in a first crown is contiguous with a proximal end of a corresponding cell in a third crown, and a distal end of each cell in a second crown is contiguous with a proximal end of a corresponding cell in a fourth crown. The second crown is disposed distal to the first crown and proximal to the third crown, and the fourth crown is disposed distal to the third crown. The plurality of crowns of cells define a tubular-shaped section forming a cylindrically closed structure. The clot mobilizer also comprises a tapered portion extending proximally from the proximal end of the working portion and comprising a plurality of struts.

Abstract: An elongated device with an improved attachment of its elements is provided. The device comprises a working element comprising a first connection portion extending proximally, the first connection portion having a first attachment surface; a pusher comprising a second connection portion extending distally, the second connection portion having a second attachment surface facing and extending longitudinally aligned to the first attachment surface to define an overlapping portion and to define first and second seams extending longitudinally along first and second lateral extents of the overlapping portion; a first weld attaching the first and second connection portions, extending from the first seam toward the second seam; and a second weld attaching the first and second connection portions, extending from the second seam toward the first seam. A method for connecting a working element to a pusher is also provided.

Abstract: Thrombectomy devices, systems and methods for extraction of vascular thrombi from a blood vessel.

Abstract: A loading device for loading a medical device into a catheter is provided. The loading device comprises a body having a lumen to receive an expandable portion of a medical device. The lumen has a length as the expandable portion when the latter is in a collapsed configuration and has a diameter that is greater than the collapsed configuration. The body comprises a first portion and a second portion that are reversibly separable to expose the lumen in an open configuration and enclose the lumen in a closed configuration. The first and second portions each comprise an inner face having a groove defining a first portion of the lumen and a second portion of the lumen, respectively. The body also has a distal tip portion to reversibly couple with a hemostatic valve of a delivery catheter. A method of loading a medical device into a catheter is also provided.

Abstract: A delivery catheter device for accessing intracranial vasculature are disclosed. The delivery catheter comprises an elongated tubular body having a lumen, a proximal section (10), a distal section (30) and at least three longitudinally arranged transition sections (20) disposed between the proximal section (10) and the distal section (30), wherein the distal section (30) is the most flexible section and the proximal section (10) is the stiffest section. A first transition section (21, 21B) has a stiffness less or equal than a stiffness of the proximal section (10), a second transition section (22) is disposed distal to the first transition section (21, 21B) and has a stiffness greater or equal than the stiffness of the first transition section (21, 21B), and a third transition section (23, 23A) is disposed distal to the second transition section (22) and has a stiffness less than the stiffness of the second transition section (22).

Abstract: A method of extracting a thrombus from a thrombus site in a cerebral artery of a patient by advancing a first catheter into an internal carotid artery of the patient; advancing a funnel catheter within the first catheter; moving the funnel catheter and the first catheter with respect to each other to place the funnel outside of the first catheter; expanding the funnel into contact with an inner wall of the internal carotid artery at or proximal to a distal end of a carotid siphon, thereby reducing blood flow past the funnel; advancing a clot-mobilizer distally through the first catheter toward the thrombus and beyond the carotid siphon; engaging thrombus material from the thrombus with the clot-mobilizer; moving the clot-mobilizer and thrombus material proximally at least partially into the funnel; applying suction to aspirate thrombus material; and moving the funnel, the clot-mobilizer and the thrombus material proximally within the vasculature.

Abstract: A loading device for loading a medical device into a catheter is provided. The loading device comprises a body having a lumen to receive an expandable portion of a medical device. The lumen has a length as the expandable portion when the latter is in a collapsed configuration and has a diameter that is greater than the collapsed configuration. The body comprises a first portion and a second portion that are reversibly separable to expose the lumen in an open configuration and enclose the lumen in a closed configuration. The first and second portions each comprise an inner face having a groove defining a first portion of the lumen and a second portion of the lumen, respectively. The body also has a distal tip portion to reversibly couple with a hemostatic valve of a delivery catheter. A method of loading a medical device into a catheter is also provided.

Abstract: A thrombectomy system and method of extraction of thrombus are disclosed. The thrombectomy system comprises a delivery catheter; an aspiration catheter, comprising an aspiration funnel, configured to be movably disposed within the delivery catheter in a retracted position and at least partially outside the delivery catheter in an extended and expanded position, the funnel comprising a non-permeable covering, the funnel being configured to adapt its shape and length to a surrounding blood vessel such that the funnel reduces blood flow through the blood vessel and lengthens as it narrows to retain a thrombus within the funnel; a clot-capture element configured to capture the thrombus and to be at least partially withdrawn with the captured thrombus into the funnel; and a microcatheter adapted to carry the clot-capture element to the thrombus. The clot-capture element is movably disposed within the microcatheter in a retracted position. The microcatheter is movably disposed within the aspiration catheter.

Abstract: A device, a thrombectomy apparatus and a method for extraction of thrombus from a blood vessel are disclosed. The device comprises a segment changing its shape from a retracted position in a compressed state to an extended and expanded position. The segment is formed by a mesh of at least two sets of helicoidal filaments turning respectively in opposite directions and being intertwined. The mesh comprises two distinct tubular sections. The mesh of the first section has helicoidal filaments with a braiding angle providing radial forces higher than in the second section, thus the first section becomes appositioned against the inner wall of the blood vessel. The second section comprises two sub-sections. The first sub-section has a conical shape and comprises a braiding angle changing at its proximal and distal ends to provide radial strength to maintain the conical shape and to stop a proximal blood flow during the removal of the thrombus.

Abstract: A thrombectomy device including a delivery catheter; a tapered dilator catheter configured to be movably disposed within the delivery catheter; and an expandable aspiration funnel configured to be movably disposed within the delivery catheter in a retracted position and at least partially outside the delivery catheter in an extended position, the funnel comprising a non-permeable covering, a diameter of a distal end of the funnel being greater in the extended position than in the retracted position, the funnel being configured to adapt its shape and length to a surrounding blood vessel such that the funnel lengthens as it narrows to retain a thrombus within the funnel. The invention also includes methods of using the device.

Abstract: A thrombectomy device including a delivery catheter; a tapered dilator catheter configured to be movably disposed within the delivery catheter; and an expandable aspiration funnel configured to be movably disposed within the delivery catheter in a retracted position and at least partially outside the delivery catheter in an extended position, the funnel comprising a non-permeable covering, a diameter of a distal end of the funnel being greater in the extended position than in the retracted position, the funnel being configured to adapt its shape and length to a surrounding blood vessel such that the funnel lengthens as it narrows to retain a thrombus within the funnel. The invention also includes methods of using the device.

Abstract: A thrombectomy device including a delivery catheter; a tapered dilator catheter configured to be movably disposed within the delivery catheter; and an expandable aspiration funnel configured to be movably disposed within the delivery catheter in a retracted position and at least partially outside the delivery catheter in an extended position, the funnel comprising a non-permeable covering, a diameter of a distal end of the funnel being greater in the extended position than in the retracted position, the funnel being configured to adapt its shape and length to a surrounding blood vessel such that the funnel lengthens as it narrows to retain a thrombus within the funnel. The invention also includes methods of using the device.