Patents by Inventor Ofir Witzman

Ofir Witzman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11344408
    Abstract: An assembly can comprise a radially expandable and compressible annular frame, at least one linear actuator assembly coupled to the frame and at least one locking mechanism coupled to the frame. The linear actuator can be configured to apply a distally directed force and/or a proximally directed force to the frame to radially expand or compress the frame. The locking mechanism can comprise a first sleeve member connected to the frame at a first location, a second sleeve member having internal threads and being connected to the frame at a second location, and a first screw configured to engage the internal threads of the second sleeve member to retain the frame in a radially expanded state.
    Type: Grant
    Filed: March 9, 2020
    Date of Patent: May 31, 2022
    Assignee: Edwards Lifesciences Corporation
    Inventors: David Maimon, Boaz Manash, Eyal Leiba, Ziv Yohanan, Yair A. Neumann, Anatoly Dvorsky, Jonathan Bar-Or, Oren Cohen, Ofir Witzman, Liron Tayeb, Elazar Levi Schwarcz, Noam Miller, Tomer Saar
  • Publication number: 20220133513
    Abstract: A crimping device includes a housing and a crimping band. The housing has a lumen for receiving a prosthetic valve. The crimping band is adjustably coupled to the housing and has a first end portion, a second end portion, and a loop. The loop of the crimping band is disposed within the lumen and move between first and second configurations. In the first configuration, the loop has a first diameter and is configured such that the prosthetic valve in a radially expanded configuration can be positioned radially within the loop. In the second configuration, the loop has a second diameter and is configured to apply a radial force on the prosthetic valve to move the prosthetic valve to a radially compressed configuration. The loop of the crimping band is configured to contact less than half of an axial length of the prosthetic valve.
    Type: Application
    Filed: January 18, 2022
    Publication date: May 5, 2022
    Applicant: Edwards Lifesciences Corporation
    Inventors: Oren Cohen, Ofir Witzman
  • Publication number: 20220110742
    Abstract: Various mechanically expandable prosthetic heart valves, as well as deliver apparatus, delivery assemblies, and methods for implanting such prosthetic heart valves. In one example, a prosthetic heart valve includes a mechanically expandable frame, a valve structure, and an actuator. The frame includes a plurality of struts and is movable between a radially compressed state and a radially expanded state. The valve structure includes a plurality of leaflets. The actuator is coupled to the frame and comprises an actuation lumen, a locking member, and a locking element. The actuation lumen is circumferentially spaced and axially parallel to the locking member. The actuation lumen is configured for receiving an axially movable actuation shaft that can move the frame between the radially compressed state and the radially expanded state. The locking element is rotatably coupled to the locking member and is configured to lock the frame at a desired state.
    Type: Application
    Filed: December 20, 2021
    Publication date: April 14, 2022
    Applicant: Edwards Lifesciences Corporation
    Inventors: Tamir S. Levi, Michael Bukin, Noam Nir, Ziv Yohanan, Elazar Levi Schwarcz, Oren Cohen, Ofir Witzman, Eitan Atias, Noam Miller, Khen Perlmutter, Boaz Manash, Eyal Leiba, Eran Goldberg
  • Patent number: 11291540
    Abstract: Docking stations for transcatheter valves are described. The docking stations can include an expandable frame, at least one sealing portion, and a valve seat. The expandable frame can be configured to conform to an interior shape of a portion of the circulatory system when expanded inside the circulatory system. The sealing portion can be configured to contact an interior surface of the circulatory system to create a seal. The valve seat can be connected to the expandable frame and can be configured to support an expandable transcatheter valve. The docking stations are adaptable to different anatomies/locations to allow implantation of a transcatheter valve in a variety of anatomies/locations.
    Type: Grant
    Filed: July 13, 2018
    Date of Patent: April 5, 2022
    Assignee: Edwards Lifesciences Corporation
    Inventors: Liron Tayeb, Eran Goldberg, David Maimon, Adi Carmi, Arie Tylis, Ofir Witzman, Ralph Schneider, Mohammad Jafari, Hengchu Cao, Eason Michael Abbott, Dustin P. Armer, Michael D. Franklin, Tomer Saar, Anatoly Dvorsky, John J. Desrosiers, Daniel James Murray, Michael G. Valdez, Assaf Bash, Amir Blumenfeld, Noa Axelrod, Eitan Atias
  • Publication number: 20210307904
    Abstract: Embodiments of a prosthetic valve delivery apparatus are disclosed. The delivery apparatus includes a first portion configured to maintain a fixed spatial relationship relative to a first end of the prosthetic valve and a second portion configured to maintain a fixed spatial relationship relative to a second end of the prosthetic valve during radial expansion of the prosthetic valve. The first portion includes one or more reference radiopaque markers and the second portion includes an indicator radiopaque marker. A position of the indicator radiopaque marker relative to the one or more reference radiopaque markers measures an axial distance between the first and second ends of the prosthetic valve indicative of a corresponding diameter of the prosthetic valve as it is radially expanded from a radially compressed state to a radially expanded state.
    Type: Application
    Filed: June 21, 2021
    Publication date: October 7, 2021
    Applicant: Edwards Lifesciences Corporation
    Inventors: Elazar Levi Schwarcz, Oren Cohen, Ofir Witzman, Yair A. Neumann, Noam Miller, Ziv Yohanan
  • Publication number: 20210282921
    Abstract: A delivery apparatus including a measurement device to monitor the real-time diameter of a prosthetic heart valve can include a handle, at least one first actuator extending from the handle and being configured to apply a distally directed force to a proximal end portion of a prosthetic heart valve, at least one second actuator extending from the handle and being configured to apply a proximally directed force to a distal end portion of a prosthetic heart valve, a sensor, and first and second motion-transmitting members coupled to the first and second actuators, respectively, and having proximal ends coupled to the sensor, wherein the sensor senses relative movement between the motion-transmitting members upon actuation of the first and second actuators to determine the diameter of the prosthetic heart valve as it expands from a radially compressed configuration to a radially expanded configuration.
    Type: Application
    Filed: April 27, 2021
    Publication date: September 16, 2021
    Applicant: Edwards Lifesciences Corporation
    Inventors: Elazar Levi Schwarcz, Oren Cohen, Tomer Saar, Yair A. Neumann, Ofir Witzman
  • Publication number: 20210244534
    Abstract: A prosthetic valve delivery assembly is disclosed. The assembly includes a delivery apparatus having a shaft and a prosthetic valve mounted in a radially compressed configuration around a distal portion of the shaft. The delivery apparatus further includes an expansion assist device mounted on the shaft. The expansion assist device is independently radially expandable and compressible relative to the prosthetic valve between a radially compressed state and a radially expanded state. The prosthetic valve is radially expandable by applying an axially directed force against the prosthetic valve in a proximal or distal direction through contact between the prosthetic valve and the expansion assist device when the expansion assist device is in the radially expanded state.
    Type: Application
    Filed: April 28, 2021
    Publication date: August 12, 2021
    Applicant: Edwards Lifesciences Corporation
    Inventors: Oren Cohen, Ofir Witzman, Elazar Levi Schwarcz
  • Publication number: 20210228352
    Abstract: In one embodiment, a delivery apparatus handle, such as for a mechanical heart valve frame can comprise an actuation knob with a toggle mechanism that can toggle the actuation knob from a first state in which the actuation knob is operable to cause the linear or rotational movement of multiple elements or sets of elements, such as tubes that are attached to, e.g., a mechanical heart valve frame to cause expansion or collapsing of the frame, to a second state in which only a single element or set of elements is moved, allowing for additional operations, such as, e.g., locking the frame and/or releasing it from the delivery apparatus.
    Type: Application
    Filed: April 12, 2021
    Publication date: July 29, 2021
    Applicant: Edwards Lifesciences Corporation
    Inventors: Oren Cohen, Ofir Witzman
  • Patent number: 10973634
    Abstract: In one embodiment, a delivery apparatus handle, such as for a mechanical heart valve frame can comprise an actuation knob with a toggle mechanism that can toggle the actuation knob from a first state in which the actuation knob is operable to cause the linear or rotational movement of multiple elements or sets of elements, such as tubes that are attached to, e.g., a mechanical heart valve frame to cause expansion or collapsing of the frame, to a second state in which only a single element or set of elements is moved, allowing for additional operations, such as, e.g., locking the frame and/or releasing it from the delivery apparatus.
    Type: Grant
    Filed: April 23, 2018
    Date of Patent: April 13, 2021
    Assignee: Edwards Lifesciences Corporation
    Inventors: Oren Cohen, Ofir Witzman
  • Patent number: 10940000
    Abstract: A delivery catheter is in various embodiments configured to deliver an anchoring device to a native valve annulus of a patient's heart, where the anchoring device can better secure a prosthesis at the native annulus. The delivery catheter can includes a distal section that includes one or more spines or is laser cut to assume a particular shape for better facilitating delivery of the anchoring device at the implant site and can include a flexible tube, a first pull wire, and a second pull wire. The flexible tube can comprise a bore extending between the first end and the second end sized for passing the anchoring device therethrough. The distal portion can comprise a first flexing section and a second flexing section. Actuation of the first pull wire and the second pull wire can cause the flexible tube to move from a first configuration to a second configuration.
    Type: Grant
    Filed: May 21, 2018
    Date of Patent: March 9, 2021
    Assignee: Edwards Lifesciences Corporation
    Inventors: Darshin S. Patel, Boaz Manash, Tri D. Tran, Ofir Witzman, Yoav Rozen, Alexander J. Siegel, David M. Taylor
  • Publication number: 20210015606
    Abstract: A prosthetic valve delivery apparatus can comprise a handle, a gearbox, an input torque shaft and a plurality of output torque shafts. The input torque shaft can extend distally from the handle and can have a distal end portion operatively connected to the gearbox. The output torque shafts can be operatively connected to and extend distally from the gearbox. Rotation of the input torque shaft can cause rotation of the output torque shafts via the gear box.
    Type: Application
    Filed: October 5, 2020
    Publication date: January 21, 2021
    Applicant: Edwards Lifesciences Corporation
    Inventors: Oren Cohen, Ofir Witzman, Yair A. Neumann
  • Publication number: 20200390547
    Abstract: An implantable prosthetic device can include a frame that is radially expandable and compressible between a radially compressed configuration and a radially expanded configuration. The frame can have a first set of a plurality of struts extending in a first direction, and a second set of a plurality of struts extending in a second direction, and each strut of the first set of struts can be pivotably connected to at least one strut of the second set of struts. Each strut can be curved helically with respect to a first, longitudinal axis of the frame, and each strut can be curved with respect to a second axis that is perpendicular to the first, longitudinal axis of the frame.
    Type: Application
    Filed: August 27, 2020
    Publication date: December 17, 2020
    Applicant: Edwards Lifesciences Corporation
    Inventors: Anatoly Dvorsky, Tamir S. Levi, Yair A. Neumann, Noa Axelrod Manela, Eitan Atias, Oren Cohen, Elazar Levi Schwarcz, Ofir Witzman, Noam Miller, Boaz Manash, Danny M. Garmahi
  • Patent number: 10806573
    Abstract: A prosthetic valve delivery apparatus can comprise a handle, a gearbox, an input torque shaft and a plurality of output torque shafts. The input torque shaft can extend distally from the handle and can have a distal end portion operatively connected to the gearbox. The output torque shafts can be operatively connected to and extend distally from the gearbox. Rotation of the input torque shaft can cause rotation of the output torque shafts via the gear box.
    Type: Grant
    Filed: August 20, 2018
    Date of Patent: October 20, 2020
    Assignee: Edwards Lifesciences Corporation
    Inventors: Oren Cohen, Ofir Witzman, Yair A. Neumann
  • Publication number: 20200297482
    Abstract: An assembly can comprise a radially expandable and compressible annular frame, at least one linear actuator assembly coupled to the frame and at least one locking mechanism coupled to the frame. The linear actuator can be configured to apply a distally directed force and/or a proximally directed force to the frame to radially expand or compress the frame. The locking mechanism can comprise a first sleeve member connected to the frame at a first location, a second sleeve member having internal threads and being connected to the frame at a second location, and a first screw configured to engage the internal threads of the second sleeve member to retain the frame in a radially expanded state.
    Type: Application
    Filed: March 9, 2020
    Publication date: September 24, 2020
    Inventors: David Maimon, Boaz Manash, Eyal Leiba, Ziv Yohanan, Yair A. Neumann, Anatoly Dvorsky, Jonathan Bar-Or, Oren Cohen, Ofir Witzman, Liron Tayeb, Elazar Levi Schwarcz, Noam Miller, Tomer Saar
  • Publication number: 20200253731
    Abstract: Devices, systems and methods are described herein to provide improved steerability for delivering a prosthesis to a body location, for example, for delivering a replacement mitral valve to a native mitral valve location. The delivery system can include a number of advantageous steering and delivery features, in particular for the transseptal delivery approach.
    Type: Application
    Filed: April 30, 2020
    Publication date: August 13, 2020
    Inventors: Boaz Manash, Oren Cohen, Noam Nir, Ilan Tamir, Eitan Atias, Ofir Witzman, Michal Aliza Ruchelsman
  • Publication number: 20200188099
    Abstract: An implantable prosthetic device can include a frame that is radially expandable and compressible between a radially compressed configuration and a radially expanded configuration. The frame can have a first set of a plurality of struts extending in a first direction, and a second set of a plurality of struts extending in a second direction, and each strut of the first set of struts can be pivotably connected to at least one strut of the second set of struts. Each strut can be curved helically with respect to a first, longitudinal axis of the frame, and each strut can be curved with respect to a second axis that is perpendicular to the first, longitudinal axis of the frame.
    Type: Application
    Filed: February 11, 2020
    Publication date: June 18, 2020
    Applicant: Edwards Lifesciences Corporation
    Inventors: Anatoly Dvorsky, Tamir S. Levi, Yair A. Neumann, Noa Axelrod Manela, Eitan Atias, Oren Cohen, Elazar Levi Schwarcz, Ofir Witzman, Noam Miller, Boaz Manash, Danny M. Garmahi
  • Publication number: 20200170789
    Abstract: Disclosed herein are representative embodiments of methods, apparatus, and systems used to deliver a prosthetic heart valve to a deficient valve. In one embodiment, for instance, a support member is positioned to at least partially surround the native leaflets of a valve. A locking member is used to couple both ends of the support member, forming a support band. An expandable prosthetic heart valve is delivered into the native heart valve and expanded while the expandable prosthetic valve is at least partially within the support band, thereby causing one or more of the native leaflets of the native heart valve to be frictionally secured between the support band and the expanded prosthetic heart valve.
    Type: Application
    Filed: February 7, 2020
    Publication date: June 4, 2020
    Inventors: Oded Meiri, Tamir S. Levi, Ofir Witzman
  • Patent number: 10646340
    Abstract: Devices, systems and methods are described herein to provide improved steerability for delivering a prosthesis to a body location, for example, for delivering a replacement mitral valve to a native mitral valve location. The delivery system can include a number of advantageous steering and delivery features, in particular for the transseptal delivery approach.
    Type: Grant
    Filed: August 17, 2017
    Date of Patent: May 12, 2020
    Assignee: Edwards Lifesciences Corporation
    Inventors: Boaz Manash, Oren Cohen, Noam Nir, Ilan Tamir, Eitan Atias, Ofir Witzman, Michal Aliza Ruchelsman
  • Patent number: 10603165
    Abstract: An assembly can comprise a radially expandable and compressible annular frame, at least one linear actuator assembly coupled to the frame and at least one locking mechanism coupled to the frame. The linear actuator can be configured to apply a distally directed force and/or a proximally directed force to the frame to radially expand or compress the frame. The locking mechanism can comprise a first sleeve member connected to the frame at a first location, a second sleeve member having internal threads and being connected to the frame at a second location, and a first screw configured to engage the internal threads of the second sleeve member to retain the frame in a radially expanded state.
    Type: Grant
    Filed: December 4, 2017
    Date of Patent: March 31, 2020
    Assignee: Edwards Lifesciences Corporation
    Inventors: David Maimon, Boaz Manash, Eyal Leiba, Ziv Yohanan, Yair A. Neumann, Anatoly Dvorsky, Jonathan Bar-Or, Oren Cohen, Ofir Witzman, Liron Tayeb, Elazar Levi Schwarcz, Noam Miller, Tomer Saar
  • Patent number: 10568736
    Abstract: Methods, apparatus, and systems used to deliver a prosthetic heart valve to a deficient valve. In one embodiment, for instance, a support member is positioned to at least partially surround the native leaflets of a valve. A locking member is used to couple both ends of the support member, forming a support band. An expandable prosthetic heart valve is delivered into the native heart valve and expanded while the expandable prosthetic valve is at least partially within the support band, thereby causing one or more of the native leaflets of the native heart valve to be frictionally secured between the support band and the expanded prosthetic heart valve.
    Type: Grant
    Filed: October 11, 2017
    Date of Patent: February 25, 2020
    Assignee: Edward Lifesciences Corporation
    Inventors: Oded Meiri, Tamir S. Levi, Ofir Witzman