Abstract: Presented systems and methods enable efficient and effective radiation treatment planning and treatment, including accurate and convenient transmission of the radiation towards a tissue target. In one embodiment, a radiation system includes a particle source, a bremsstrahlung target, and a pinhole collimator. The particle source is configured to produce a particle beam (e.g., an electron beam, etc.). The bremsstrahlung target is configured to receive the particle beam and generate a photon radiation beam. The received particle beam and generated photon radiation beam can correspond to an inflected image. The inflected image can be associated with a tumor/tissue target. The pinhole collimator is configured to receive the photon radiation beam in a pattern that corresponds to the inflected image, invert the photon radiation beam pattern, and forward the results towards a tissue target.