Abstract: The present invention relates to RNAi constructs for reducing expression of the ASGR1 gene. Methods of using such RNAi constructs to treat or prevent cardiovascular disease, such as coronary artery disease and myocardial infarction, and to reduce serum non-HDL cholesterol levels are also described.

Abstract: This invention relates to combination therapies comprising a Programmed Death 1 receptor (PD-1) pathway inhibitor, and a Leukocyte Immunoglobulin Like Receptor B (LILRB) signaling inhibitor, and the use of the combination therapies for the treatment of cancer. The invention also relates to the treatment of cancer patients who are refractory to monotherapy with a PD-1 pathway inhibitor.

Abstract: The present invention relates to RNAi constructs for reducing expression of the ASGR1 gene. Methods of using such RNAi constructs to treat or prevent cardiovascular disease, such as coronary artery disease and myocardial infarction, and to reduce serum non-HDL cholesterol levels are also described.

Abstract: The present invention relates to RNAi constructs for reducing expression of the ASGR1 gene. Methods of using such RNAi constructs to treat or prevent cardiovascular disease, such as coronary artery disease and myocardial infarction, and to reduce serum non-HDL cholesterol levels are also described.

Abstract: The present invention relates to RNAi constructs for reducing expression of the ASGR1 gene. Methods of using such RNAi constructs to treat or prevent cardiovascular disease, such as coronary artery disease and myocardial infarction, and to reduce serum non-HDL cholesterol levels are also described.

Abstract: A Bradbury-Nielson gate (BNG) includes a set of evenly spaced, co-planar, and parallel wires. The wires alternate in a repeating ABAB pattern, where all of the A wires are electrically connected to each other, all of the B wires are electrically connected to each other, and the set of A wires is electrically isolated from the set of B wires. Improved fabrication of Bradbury-Nielson gates is provided based on two key ideas. The first key idea is the use of wire positioning template surfaces having wire insertion features with enhanced spacing. Wire insertion features having enhanced spacing allow for non-microscopic assembly of finely spaced wire arrays. The second key idea is the use of two template surfaces, each having wires spaced by twice the eventual gate wire spacing. The use of two template surfaces facilitates making the alternating electrical contact required for a BNG.

Abstract: Improved mass spectrometry is provided by modulating the fragmentation efficiency of analyte ions according to a modulation input signal. The fragmentation modulated ions are then analyzed according to time of flight and according to either ion kinetic energy or ion momentum to provide measured data. A mathematical inversion corresponding to the modulation input is applied to the measured data along the time axis to deconvolute the effect of the modulation input signal on the data, thereby providing 2-D data for time of flight vs. energy/momentum for precursor ions and fragment ions simultaneously. After the dissociation, the ion velocity remains almost unchanged, but the kinetic energy or momentum is partitioned amongst the fragments. Thus, the time of flight and energy/momentum can be converted to precursor mass and fragment mass to obtain 2-D spectrum of fragments vs. their corresponding precursors. The resulting technique can be referred to as fragmentation modulation mass spectrometry (FMMS).

Abstract: A Bradbury-Nielson gate (BNG) includes a set of evenly spaced, co-planar, and parallel wires. The wires alternate in a repeating ABAB pattern, where all of the A wires are electrically connected to each other, all of the B wires are electrically connected to each other, and the set of A wires is electrically isolated from the set of B wires. Improved fabrication of Bradbury-Nielson gates is provided based on two key ideas. The first key idea is the use of wire positioning template surfaces having wire insertion features with enhanced spacing. Wire insertion features having enhanced spacing allow for non-microscopic assembly of finely spaced wire arrays. The second key idea is the use of two template surfaces, each having wires spaced by twice the eventual gate wire spacing. The use of two template surfaces facilitates making the alternating electrical contact required for a BNG.