Patents by Inventor Ohad Karnieli
Ohad Karnieli has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11859163Abstract: An inverted conical bioreactor is provided for growing cells or microorganisms. The bioreactor has an internal space and a perforated barrier within the vessel, through which a liquid may flow, where cells or microorganisms cannot pass through the perforated barrier. The perforated barrier divides the internal space of the bioreactor into a first chamber and a second chamber. Cells are grown within the second chamber and can be perfused by re-circulating the liquid, for example a growth medium, through the bioreactor. Various inlet ports and outlet ports allow controlling the parameters of flow of the growth medium.Type: GrantFiled: October 24, 2022Date of Patent: January 2, 2024Assignee: ADVA Biotechnology Ltd.Inventor: Ohad Karnieli
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Publication number: 20230383236Abstract: Bioreactor systems and controlled operation of bioreactor systems are disclosed herein. The bioreactor systems can include at least one bioreactor chamber, at least one reservoir, a plurality of sensors, and a fluid circuit. The operational methods disclosed herein are directed towards growing cells or tissue while measuring various parameters, and a controlled operation of the various parameters during the operation of the bioreactor systems. The controlled operation of the parameters includes, for example, cell concentration; a rate of flow; a volume; a pH; a temperature; a level of oxygen; a level of carbon dioxide; a level of bicarbonate ion; nutrient compound; and any combination thereof.Type: ApplicationFiled: April 4, 2023Publication date: November 30, 2023Inventors: Ohad KARNIELI, Noam BERCOVICH
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Publication number: 20230340387Abstract: A decentralized distributed vaccine manufacturing systems and methods thereof provide a cost effective, simple to operate, automated, and small-scale development and manufacturing process by automated computer-controlled devices. The devices and methods disclosed that allows localized vaccine development and manufacture. The bioreactor systems can include at least one bioreactor chamber, at least one reservoir, a plurality of sensors, and a fluid circuit. The operational methods disclosed herein are directed towards growing cells or tissue while measuring various parameters, and a controlled operation of the various parameters during the operation of the bioreactor systems.Type: ApplicationFiled: April 1, 2021Publication date: October 26, 2023Inventors: Ohad KARNIELI, Barbara PALDUS
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Patent number: 11667882Abstract: Bioreactor systems and controlled operation of bioreactor systems are disclosed herein. The bioreactor systems can include at least one bioreactor chamber, at least one reservoir, a plurality of sensors, and a fluid circuit. The operational methods disclosed herein are directed towards growing cells or tissue while measuring various parameters, and a controlled operation of the various parameters during the operation of the bioreactor systems. The controlled operation of the parameters includes, for example, cell concentration; a rate of flow; a volume; a pH; a temperature; a level of oxygen; a level of carbon dioxide; a level of bicarbonate ion; nutrient compound; and any combination thereof.Type: GrantFiled: March 7, 2022Date of Patent: June 6, 2023Assignee: ADVA BIOTECHNOLOGY LTD.Inventors: Ohad Karnieli, Noam Bercovich
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Publication number: 20230099216Abstract: An inverted conical bioreactor is provided for growing cells or microorganisms. The bioreactor has an internal space and a perforated barrier within the vessel, through which a liquid may flow, where cells or microorganisms cannot pass through the perforated barrier. The perforated barrier divides the internal space of the bioreactor into a first chamber and a second chamber. Cells are grown within the second chamber and can be perfused by re-circulating the liquid, for example a growth medium, through the bioreactor. Various inlet ports and outlet ports allow controlling the parameters of flow of the growth medium.Type: ApplicationFiled: October 24, 2022Publication date: March 30, 2023Inventor: Ohad KARNIELI
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Patent number: 11549090Abstract: An inverted conical bioreactor is provided for growing cells or microorganisms. The bioreactor has an internal space and a perforated barrier within the vessel, through which a liquid may flow, where cells or microorganisms cannot pass through the perforated barrier. The perforated barrier divides the internal space of the bioreactor into a first chamber and a second chamber. Cells are grown within the second chamber and can be perfused by re-circulating the liquid, for example a growth medium, through the bioreactor. Various inlet ports and outlet ports allow controlling the parameters of flow of the growth medium.Type: GrantFiled: August 21, 2017Date of Patent: January 10, 2023Assignee: ADVA BIOTECHNOLOGY LTD.Inventor: Ohad Karnieli
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Publication number: 20220204905Abstract: A bioreactor with a closed vessel, a reaction chamber, and at least one barrier, wherein the bioreactor is configured to support a biologically active environment. The barrier for the reaction chamber of the bioreactor includes pores and a media flow path connected to the pores. The media flow path is configured to have a diameter that is smaller than the average diameter of the pores. The barrier of the bioreactor includes a surface feature, internal structural feature, or combinations thereof, which are configured to improve or enhance the growth of cells or microorganisms.Type: ApplicationFiled: December 27, 2021Publication date: June 30, 2022Inventors: Ohad KARNIELI, Noam BERCOVINCH, Mahmoud ABU EL HIJA
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Publication number: 20220195375Abstract: Bioreactor systems and controlled operation of bioreactor systems are disclosed herein. The bioreactor systems can include at least one bioreactor chamber, at least one reservoir, a plurality of sensors, and a fluid circuit. The operational methods disclosed herein are directed towards growing cells or tissue while measuring various parameters, and a controlled operation of the various parameters during the operation of the bioreactor systems. The controlled operation of the parameters includes, for example, cell concentration; a rate of flow; a volume; a pH; a temperature; a level of oxygen; a level of carbon dioxide; a level of bicarbonate ion; nutrient compound; and any combination thereof.Type: ApplicationFiled: March 7, 2022Publication date: June 23, 2022Inventors: Ohad KARNIELI, Noam BERCOVICH
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Publication number: 20210222114Abstract: Bioreactor systems and controlled operation of bioreactor systems are disclosed herein. The bioreactor systems can include at least one bioreactor chamber, at least one reservoir, a plurality of sensors, and a fluid circuit. The operational methods disclosed herein are directed towards growing cells or tissue while measuring various parameters, and a controlled operation of the various parameters during the operation of the bioreactor systems. The controlled operation of the parameters includes, for example, cell concentration; a rate of flow; a volume; a pH; a temperature; a level of oxygen; a level of carbon dioxide; a level of bicarbonate ion; nutrient compound; and any combination thereof.Type: ApplicationFiled: January 20, 2021Publication date: July 22, 2021Inventors: Ohad KARNIELI, Noam BERCOVICH
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Patent number: 10392593Abstract: This disclosure is directed to methods and systems for growing and/or harvesting cells. The method can include seeding cells on a plurality of carriers. The method can also include incubating the carriers under conditions suitable for cell growth.Type: GrantFiled: March 3, 2015Date of Patent: August 27, 2019Assignee: PLURISTEM LTD.Inventors: Harel Kasuto, Ohad Karnieli, Dotan Hoffman, Lior Raviv
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Publication number: 20190211294Abstract: An inverted conical bioreactor is provided for growing cells or microorganisms. The bioreactor has an internal space and a perforated barrier within the vessel, through which a liquid may flow, where cells or microorganisms cannot pass through the perforated barrier. The perforated barrier divides the internal space of the bioreactor into a first chamber and a second chamber. Cells are grown within the second chamber and can be perfused by re-circulating the liquid, for example a growth medium, through the bioreactor. Various inlet ports and outlet ports allow controlling the parameters of flow of the growth medium.Type: ApplicationFiled: August 21, 2017Publication date: July 11, 2019Applicant: ADVA BIOTECHNOLOGY LTD.Inventor: Ohad KARNIELI
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Patent number: 10251389Abstract: This disclosure is a system for heating a sample, e.g. a biological material, in a vessel. The system can include a heating device configured to transmit energy to the vessel and a base moveably coupled to the heating device. The system can also include a processor configured to receive an input associated with a target temperature, and transmit a signal to controllably move the heating device relative to the base for a time period, wherein the time period is determined based on the target temperature and content volume.Type: GrantFiled: January 15, 2015Date of Patent: April 9, 2019Assignee: PLURISTEM LTD.Inventors: Ohad Karnieli, Tal Slonim, Lior Raviv, Nufar Gross
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Publication number: 20170073625Abstract: This disclosure is directed to methods and systems for growing and/or harvesting cells. The method can include seeding cells on a plurality of carriers. The method can also include incubating the carriers under conditions suitable for cell growth.Type: ApplicationFiled: March 3, 2015Publication date: March 16, 2017Applicant: Pluristem Ltd.Inventors: Harel Kasuto, Ohad Karnieli, Dotan Hoffman, Lior Raviv
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Publication number: 20150125138Abstract: This disclosure is a system for heating a sample, e.g. a biological material, in a vessel. The system can include a heating device configured to transmit energy to the vessel and a base moveably coupled to the heating device. The system can also include a processor configured to receive an input associated with a target temperature, and transmit a signal to controllably move the heating device relative to the base for a time period, wherein the time period is determined based on the target temperature and content volume.Type: ApplicationFiled: January 15, 2015Publication date: May 7, 2015Applicant: Pluristem Ltd.Inventors: Ohad Karnieli, Tal Slonim, Lior Raviv, Nufar Gross
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Patent number: D961115Type: GrantFiled: January 20, 2020Date of Patent: August 16, 2022Assignee: ADVA BIOTECHNOLOGY LTD.Inventors: Ohad Karnieli, Noam Bercovich