Abstract: An adapter including at least one wall defining a chamber, at least one opening within the wall, and a water-soluble additive coating at least a portion of the wall such that fluid flowing from one opening through the chamber dissolves the water-soluble additive within the chamber.

Abstract: This invention provides a kit for making an adhesive and/or a sealant which includes: a first composition of alginate and a multivalent cation salt at a concentration ratio (mg/ml) of 30:1 to 1:60, and a second composition of alginate and a buffer, wherein the buffer has a pH value of between 2 to 7. The invention also provides a method for making a sealant or an adhesive, by contacting the first composition and the second composition.

Abstract: This invention provides a kit for making an adhesive and/or a sealant which includes: a first composition of alginate and a multivalent cation salt at a concentration ratio (mg/ml) of 30:1 to 1:60, and a second composition of alginate and a buffer, wherein the buffer has a pH value of between 2 to 7. The invention also provides a method for making a sealant or an adhesive, by contacting the first composition and the second composition.

Abstract: This invention provides a kit for making an adhesive and/or a sealant which includes: a first composition of alginate and a multivalent cation salt at a concentration ratio (mg/ml) of 30:1 to 1:60, and a second composition of alginate and a buffer, wherein the buffer has a pH value of between 2 to 7. The invention also provides a method for making a sealant or an adhesive, by contacting the first composition and the second composition.

Abstract: Method comprising: applying uncured pre-gel (UP to surface; contacting UP with cross-linking agents; allowing applied UP to cure, increasing adhere to first surface, source of agents; solid support comprising agent, or insoluble agent salt in UP, wherein trigger compound is added to UP, or spraying/coating agent, with solid support added.

Abstract: Method comprising: applying uncured pre-gel (UP) to surface; contacting UP with cross-linking agents; allowing applied UP to cure, increasingly adhere to first surface, source of agents: solid support comprising agent, or insoluble agent salt in UP, wherein trigger compound is added to UP, or spraying/coating agent, with solid support added.

Abstract: A method of in-situ adhering comprising providing pre-gel that comprises a mixture of at least one phenol-based compound and at least one water miscible polymer selected from at least one of a naturally existing form of a carbohydrate, a synthetically prepared form of carbohydrate and a salt of an anionic polysaccharide; spreading a layer of the pre-gel onto a first surface; adding a solid support, comprising at least one cross linking agent capable of interacting with the water miscible polymer to the pre-gel; and allowing the pre-gel to cure and adhere onto the first surface.

Abstract: A method of in-situ adhering including providing pre-gel including phenolic compound and water miscible polymers like carbohydrates, salts of anionic polysaccharide, spreading layer of pre-gel onto a surface, adding solid support, comprising cross linking agents capable of interacting with the polymer, to pre-gel, and allowing pre-gel to cure and adhere onto surface.

Abstract: Apparatus is provided for applying one or more patches to a tubular structure in a body of a patient. The apparatus includes an applicator, which is configured to removably hold the one or more patches, and to place the one or more patches at least partially around the tubular structure. The applicator includes one or more patch supports. Each of the patch supports includes a yielding pad, which is removably coupleable to one of the patches; and a stiff back support structure, to which the yielding pad is fixed. Each of the patch supports is shaped so as to define at least one chamber that itself has a volume of at least 0.5 ml when the patch supports are in respective resting states. Other embodiments are also described.

Abstract: A composition including pre-gel including at least one phenol-based compound, excluding phloroglucinol and derivatives, at least one water miscible polymer, at least one cross linking agent capable of interacting with the polymer. The polymer is selected from one or more natural and/or synthetic carbohydrate, and salt of an anionic polysaccharide.

Abstract: Apparatus is provided for applying one or more patches to a tubular structure in a body of a patient. The apparatus includes an applicator, which is configured to removably hold the one or more patches, and to place the one or more patches at least partially around the tubular structure. The applicator includes one or more patch supports. Each of the patch supports includes a yielding pad, which is removably coupleable to one of the patches; and a stiff back support structure, to which the yielding pad is fixed. Each of the patch supports is shaped so as to define at least one chamber that itself has a volume of at least 0.5 ml when the patch supports are in respective resting states. Other embodiments are also described.

Abstract: In situ application of reinforced adhesive: applying uncured and curable matter to a surface, applying biocompatible inert reinforcing agent comprising at least one curing agent to the uncured composition; allowing curing within subject, cured composition together with the added reinforcing agent being configured to have improved mechanical support and strength.

Abstract: Method comprising: applying uncured pre-gel (UP) to surface; contacting UP with cross-linking agents; allowing applied UP to cure, increasingly adhere to first surface, source of agents: solid support comprising agent, or insoluble agent salt in UP, wherein trigger compound is added to UP, or spraying/coating agent, with solid support added.

Abstract: Apparatus is provided for use with a tubular structure (2) in a body of a patient. The apparatus includes an adhesive including first and second components, a container (27), one or more patches (3), and an applicator (1). The container (27) contains the first component of the adhesive and not the second component of the adhesive. The one or more patches (3) include the second component of the adhesive and not the first component of the adhesive. The applicator (1) is configured to removably hold the one or more patches (3), and to place the one or more patches (3) at least partially around the tubular structure (2). Other embodiments are also described.

Abstract: A method of in-situ adhering including providing pre-gel including phenolic compound and water miscible polymers like carbohydrates, salts of anionic polysaccharide, spreading layer of pre-gel onto a surface, adding solid support, comprising cross linking agents capable of interacting with the polymer, to pre-gel, and allowing pre-gel to cure and adhere onto surface.

Abstract: A composition including pre-gel including at least one phenol-based compound, excluding phloroglucinol and derivatives, at least one water miscible polymer, at least one cross linking agent capable of interacting with the polymer. The polymer is selected from one or more natural and/or synthetic carbohydrate, and salt of an anionic polysaccharide.