Patent number: 7879848
Abstract: Novel compounds exhibiting good inhibitory activity versus Dipeptidyl Peptidase-IV(DPP-IV) include those of the following formula (1) or pharmaceutically acceptable salt thereof: wherein A is a substituted or unsubstituted 1,4,5,7-tetrahydro-pyrazolo[3,4-c]pyridine, 5,6 -dihydro-8H-[1,2,4]triazolo[4,3-a]pyrazine, 4,5-dihydro-7H-isooxazolo[3,4-c]pyridine, 3,4 -dihydroisoquinoline, 5,8-dihydropyrido[3,4-d]pyrimidine, or 6,7 -dihydro[1,3]thiazolo[4,5,c]pyridine, and B is a substituted or unsubstituted piperidin-2-one, morpholin-3-one, oxazolidin-2-one, pyrrolidin-2-one, or 1,5-dihydro-pyrrol-2-one. Methods of preparing the novel inhibitory compounds of formula (1) and pharmaceutical compositions containing the same as an active agent are disclosed.
Type:
Grant
Filed:
March 30, 2006
Date of Patent:
February 1, 2011
Assignee:
LG Life Sciences, Ltd.
Inventors:
Chang-Seok Lee, Jong Sung Koh, Ki Dong Koo, Geun Tae Kim, Kyoung-Hee Kim, Sang Yong Hong, Sungsub Kim, Min-Jung Kim, Hyeon Joo Yim, Dongchul Lim, Hye Jin Kim, Hee Oon Han, Seong Cheol Bu, Oh Hwan Kwon, Sung Ho Kim, Gwong-Cheung Hur, Ji Young Kim, Zi-Ho Yeom, Dong-Jun Yeo