Abstract: The present invention relates to 21-deoxymacbecin analogues that are useful, e.g. in the treatment of cancer, B-cell malignancies, malaria, fungal infection, diseases of the central nervous system and neurodegenerative diseases, diseases dependent on angiogenesis, autoimmune diseases or as a prophylactic pretreatment for cancer. The present invention also provides methods for the production of these compounds and their use in medicine, in particular in the treatment and or prophylaxis of cancer or B-cell malignancies.

Abstract: In a method and an apparatus for transforming the coordinate system of MRI-guided medical equipment to the coordinate system of an MRI system MRI imaging is used to determine the rotational and translational values of the coordinate system of MRI-guided medical equipment relative to the coordinate system of an MRI system, so as to achieve the transformation. A number of fiducial markers are arranged in the MRI-guided medical equipment, and a coil winding is arranged on each fiducial marker for generating signals to determine its position in the coordinate system of the MRI system. The coil windings are serially connected and the serially connected windings are connected to the magnetic resonance system via an interface circuit.