Patents by Inventor Oihana MURILLO SAUCA

Oihana MURILLO SAUCA has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • NUCLEIC ACID CONSTRUCTS AND GENE THERAPY VECTORS FOR USE IN THE TREATMENT OF WILSON DISEASE
    Publication number: 20220008559
    Abstract: The invention relates to nucleic acid constructs and gene therapy vectors that comprise an ATP7B variant for use in the treatment of conditions associated with a deficiency or dysfunction of Copper-transporting ATPase 2, and particularly of Wilson's disease. An AAV vector devised according to the invention significantly reduced urine Cu excretion, and liver Cu content in Wilson's disease mice treated with the vector, while ceruloplasmin activity was significantly restored. On the other hand, the administration of the vector resulted in the normalization of serum transaminases' levels and of liver histology, together with a marked reduction of the inflammatory infiltrate.
    Type: Application
    Filed: September 24, 2021
    Publication date: January 13, 2022
    Applicant: FUNDACIÓN PARA LA INVESTIGACIÓN MÈDICA APLICADA
    Inventors: Oihana MURILLO SAUCA, Gloria GONZÁLEZ ASEGUINOLAZA, Rubén HERNÁNDEZ ALCOCEBA
  • Nucleic acid constructs and gene therapy vectors for use in the treatment of Wilson disease
    Patent number: 11147887
    Abstract: The invention relates to nucleic acid constructs and gene therapy vectors that comprise an ATP7B variant for use in the treatment of conditions associated with a deficiency or dysfunction of Copper-transporting ATPase 2, and particularly of Wilson's disease. An AAV vector devised according to the invention significantly reduced urine Cu excretion, and liver Cu content in Wilson's disease mice treated with the vector, while ceruloplasmin activity was significantly restored. On the other hand, the administration of the vector resulted in the normalization of serum transaminases' levels and of liver histology, together with a marked reduction of the inflammatory infiltrate.
    Type: Grant
    Filed: December 17, 2015
    Date of Patent: October 19, 2021
    Assignee: FUNDACIÓN PARA LA INVESTIGACIÓN MÈDICA APLICADA
    Inventors: Oihana Murillo Sauca, Gloria González Aseguinolaza, Rubén Hernández Alcoceba
  • Nucleic acid constructs and gene therapy vectors for use in the treatment of Wilson's disease and other conditions
    Patent number: 11118238
    Abstract: The invention relates to a nucleic acid construct carrying ATP7B protein, an expression vector and a viral particle comprising the nucleic acid construct, and their use for treatment of Wilson's disease and other conditions caused by a deficiency or dysfunction of ATP7B protein. An AAV vector devised according to the invention significantly reduced urine Cu excretion, and liver Cu content in Wilson's disease mice treated with the vector, while ceruloplasmin activity was significantly restored. On the other hand, the administration of the vector resulted in the normalization of serum transaminases levels and of liver histology, together with a marked reduction of the inflammatory infiltrate.
    Type: Grant
    Filed: December 17, 2015
    Date of Patent: September 14, 2021
    Assignee: FUNDACIÓN PARA LA INVESTIGACIÓN MÈDICA APLICADA
    Inventors: Oihana Murillo Sauca, Gloria González Aseguinolaza, Rubén Hernández Alcoceba
  • NUCLEIC ACID CONSTRUCTS AND GENE THERAPY VECTORS FOR USE IN THE TREATMENT OF WILSON'S DISEASE AND OTHER CONDITIONS
    Publication number: 20170356060
    Abstract: The invention relates to a nucleic acid construct carrying ATP7B protein, an expression vector and a viral particle comprising the nucleic acid construct, and their use for treatment of Wilson's disease and other conditions caused by a deficiency or dysfunction of ATP7B protein. An AAV vector devised according to the invention significantly reduced urine Cu excretion, and liver Cu content in Wilson's disease mice treated with the vector, while ceruloplasmin activity was significantly restored. On the other hand, the administration of the vector resulted in the normalization of serum transaminases levels and of liver histology, together with a marked reduction of the inflammatory infiltrate.
    Type: Application
    Filed: December 17, 2015
    Publication date: December 14, 2017
    Applicant: FUNDACIÓN PARA LA INVESTIGACIÓN MÈDICA APLICADA
    Inventors: Oihana MURILLO SAUCA, Gloria GONZÁLEZ ASEGUINOLAZA, Rubén HERNÁNDEZ ALCOCEBA
  • NUCLEIC ACID CONSTRUCTS AND GENE THERAPY VECTORS FOR USE IN THE TREATMENT OF WILSON DISEASE
    Publication number: 20170348435
    Abstract: The invention relates to nucleic acid constructs and gene therapy vectors that comprise an ATP7B variant for use in the treatment of conditions associated with a deficiency or dysfunction of Copper-transporting ATPase 2, and particularly of Wilson's disease. An AAV vector devised according to the invention significantly reduced urine Cu excretion, and liver Cu content in Wilson's disease mice treated with the vector, while ceruloplasmin activity was significantly restored. On the other hand, the administration of the vector resulted in the normalization of serum transaminases' levels and of liver histology, together with a marked reduction of the inflammatory infiltrate.
    Type: Application
    Filed: December 17, 2015
    Publication date: December 7, 2017
    Applicant: FUNDACIÓN PARA LA INVESTIGACIÓN MÈDICA APLICADA
    Inventors: Oihana MURILLO SAUCA, Gloria GONZÁLEZ ASEGUINOLAZA, Rubén HERNÁNDEZ ALCOCEBA