Patents by Inventor Oivin M. Guicherit

Oivin M. Guicherit has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Mediators of hedgehog signaling pathways, compositions and uses related thereto
    Patent number: 9173869
    Abstract: The present invention makes available methods and reagents for inhibiting aberrant growth states resulting from hedgehog gain-of-function by contacting the cell with a hedgehog antagonist, such as a small molecule, in a sufficient amount to aberrant growth state, e.g., to agonize a normal ptc pathway or antagonize hedgehog activity.
    Type: Grant
    Filed: April 28, 2010
    Date of Patent: November 3, 2015
    Assignee: CURIS, INC.
    Inventors: Oivin M. Guicherit, Lee Rubin
  • Mediators of hedgehog signaling pathways, compositions and uses related hereto
    Patent number: 8815895
    Abstract: The present invention makes available methods and reagents for inhibiting aberrant growth states resulting from hedgehog gain-of-function, ptc loss-of-function or smoothened gain-of-function comprising contacting the cell with a hedgehog antagonist of formula (I) in a sufficient amount to aberrant growth state, e.g., to agonize a normal ptc pathway or antagonize smoothened or hedgehog activity.
    Type: Grant
    Filed: March 16, 2012
    Date of Patent: August 26, 2014
    Assignees: Curis, Inc., Genentech, Inc.
    Inventors: Oivin M. Guicherit, Edward Andrew Boyd, Shirley Ann Brunton, Stephen Price, John Harry Alexander Stibbard, Colin H. Mackinnon
  • MEDIATORS OF HEDGEHOG SIGNALING PATHWAYS, COMPOSITIONS AND USES RELATED HERETO
    Publication number: 20120283258
    Abstract: The present invention makes available methods and reagents for inhibiting aberrant growth states resulting from hedgehog gain-of-function, ptc loss-of-function or smoothened gain-of-function comprising contacting the cell with a hedgehog antagonist of formula (I) in a sufficient amount to aberrant growth state, e.g., to agonize a normal ptc pathway or antagonize smoothened or hedgehog activity.
    Type: Application
    Filed: March 16, 2012
    Publication date: November 8, 2012
    Applicants: CURIS, INC., GENENTECH, INC.
    Inventors: Oivin M. GUICHERIT, Edward Andrew BOYD, Judith Boyd, Shirley Ann BRUNTON, Stephen PRICE, John Harry Alexander STIBBARD, Colin H. MACKINNON
  • SMALL ORGANIC MOLECULE REGULATORS OF CELL PROLIFERATION
    Publication number: 20120245184
    Abstract: The present invention makes available methods and reagents for modulating proliferation or differentiation in a cell or tissue comprising contacting the cell with a compound. In certain embodiments, the methods and reagents may be employed to correct or inhibit an aberrant or unwanted growth state, e.g., by antagonizing a normal patched pathway or agonizing smoothened or hedgehog activity.
    Type: Application
    Filed: June 8, 2012
    Publication date: September 27, 2012
    Inventors: Shirley Ann Brunton, Oivin M. Guicherit, Lawrence I. Kruse
  • Small organic molecule regulators of cell proliferation
    Patent number: 8273747
    Abstract: The present invention makes available methods and reagents for modulating proliferation or differentiation in a cell or tissue comprising contacting the cell with a compound. In certain embodiments, the methods and reagents may be employed to correct or inhibit an aberrant or unwanted growth state, e.g., by antagonizing a normal patched pathway or agonizing smoothened or hedgehog activity.
    Type: Grant
    Filed: November 2, 2007
    Date of Patent: September 25, 2012
    Assignee: Curis, Inc.
    Inventors: Shirley Ann Brunton, Oivin M. Guicherit, Lawrence I. Kruse
  • Mediators of hedgehog signaling pathways, compositions and uses related thereto
    Patent number: 8168653
    Abstract: The present invention makes available methods and reagents for inhibiting aberrant growth states resulting from hedgehog gain-of-function, ptc loss-of-function or smoothened gain-of-function comprising contacting the cell with a hedgehog antagonist of formula (I) in a sufficient amount to aberrant growth state, e.g., to agonize a normal ptc pathway or antagonize smoothened or hedgehog activity.
    Type: Grant
    Filed: August 2, 2010
    Date of Patent: May 1, 2012
    Assignees: Curis, Inc., Genentech, Inc.
    Inventors: Oivin M. Guicherit, Edward Andrew Boyd, Shirley Ann Brunton, Stephen Price, John Harry Alexander Stibbard, Colin H. Mackinnon
  • MEDIATORS OF HEDGEHOG SIGNALING PATHWAYS, COMPOSITIONS AND USES RELATED THERETO
    Publication number: 20110077256
    Abstract: The present invention makes available methods and reagents for inhibiting aberrant growth states resulting from hedgehog gain-of-function by contacting the cell with a hedgehog antagonist, such as a small molecule, in a sufficient amount to aberrant growth state, e.g., to agonize a normal ptc pathway or antagonize hedgehog activity.
    Type: Application
    Filed: April 28, 2010
    Publication date: March 31, 2011
    Inventors: Oivin M. Guicherit, Lee Rubin
  • Mediators of hedgehog signaling pathways, compositions and uses related thereto
    Publication number: 20100317660
    Abstract: The present invention makes available methods and reagents for inhibiting aberrant growth states resulting from hedgehog gain-of-function, ptc loss-of-function or smoothened gain-of-function comprising contacting the cell with a hedgehog antagonist of formula (I) in a sufficient amount to aberrant growth state, e.g., to agonize a normal ptc pathway or antagonize smoothened or hedgehog activity.
    Type: Application
    Filed: August 2, 2010
    Publication date: December 16, 2010
    Inventors: Oivin M. Guicherit, Edward Andrew Boyd, Judith Boyd, Shirley Ann Brunton, Stephen Price, John Harry Alexander Stibbard, Colin H. Mackinnon
  • Mediators of hedgehog signaling pathways, compositions and uses related thereto
    Patent number: 7816369
    Abstract: The present invention makes available methods and reagents for inhibiting aberrant growth states resulting from hedgehog gain-of-function, ptc loss-of-function or smoothened gain-of-function comprising contacting the cell with a hedgehog antagonist, such as a small molecule, in a sufficient amount to aberrant growth state, e.g., to agonize a normal ptc pathway or antagonize smoothened or hedgehog activity.
    Type: Grant
    Filed: November 3, 2005
    Date of Patent: October 19, 2010
    Assignees: Curis, Inc., Genentech, Inc.
    Inventors: Oivin M. Guicherit, Edward Andrew Boyd, Judith Boyd, legal representative, Shirley Ann Brunton, Stephen Price, John Harry Alexander Stibbard, Colin H. MacKinnon
  • Small organic molecule regulators of cell proliferation
    Publication number: 20080194637
    Abstract: The present invention makes available methods and reagents for modulating proliferation or differentiation in a cell or tissue comprising contacting the cell with a compound. In certain embodiments, the methods and reagents may be employed to correct or inhibit an aberrant or unwanted growth state, e.g., by antagonizing a normal patched pathway or agonizing smoothened or hedgehog activity.
    Type: Application
    Filed: November 2, 2007
    Publication date: August 14, 2008
    Applicants: Curis, Inc., Wyeth
    Inventors: Shirley Ann Brunton, Oivin M. Guicherit, Simon N. Haydar, Lawrence I. Kruse, Dane Springer
  • Small organic molecule regulators of cell proliferation
    Publication number: 20080193423
    Abstract: The present invention makes available methods and reagents for modulating proliferation or differentiation in a cell or tissue comprising contacting the cell with a compound. In certain embodiments, the methods and reagents may be employed to correct or inhibit an aberrant or unwanted growth state, e.g., by antagonizing a normal patched pathway or agonizing smoothened or hedgehog activity.
    Type: Application
    Filed: November 2, 2007
    Publication date: August 14, 2008
    Applicant: Curis, Inc.
    Inventors: Shirley Ann Brunton, Oivin M. Guicherit, Lawrence I. Kruse
  • Small organic molecule regulators of cell proliferation
    Publication number: 20080182859
    Abstract: The present invention makes available methods and reagents for modulating proliferation or differentiation in a cell or tissue comprising contacting the cell with a compound. In certain embodiments, the methods and reagents may be employed to correct or inhibit an aberrant or unwanted growth state, e.g., by antagonizing a normal patched pathway or agonizing smoothened or hedgehog activity.
    Type: Application
    Filed: November 2, 2007
    Publication date: July 31, 2008
    Applicant: Curis, Inc.
    Inventors: Shirley Ann Brunton, Oivin M. Guicherit, Lawrence I. Kruse
  • Agonists of hedgehog signaling pathways and uses related thereto
    Patent number: 6683108
    Abstract: The present invention makes available methods and reagents for inducing activation of a hedgehog pathway in a cell or tissue comprising contacting the cell with a hedgehog agonist, such as a small molecule, in a sufficient amount to achieve a therapeutic result. In certain embodiments, the methods and reagents may be employed to correct or inhibit an aberrant or unwanted growth state, e.g., by antagonizing a normal ptc pathway or agonizing smoothened or hedgehog activity.
    Type: Grant
    Filed: November 28, 2000
    Date of Patent: January 27, 2004
    Assignee: Curis, Inc.
    Inventors: Anthony David Baxter, Edward Andrew Boyd, Oivin M. Guicherit, Jeffrey Porter, Stephen Price, Lee Rubin
  • Small organic molecule regulators of cell proliferation
    Patent number: 6683192
    Abstract: A compound represented in general formula (X) and (XI):
    Type: Grant
    Filed: September 26, 2001
    Date of Patent: January 27, 2004
    Assignee: Curis, Inc.
    Inventors: Anthony David Baxter, Edward Andrew Boyd, Oivin M. Guicherit, Jeffrey Porter, Stephen Price, Lee Rubin, John Harry Alexander Stibbard
  • Small organic molecule regulators of cell proliferation
    Patent number: 6613798
    Abstract: The present invention makes available methods and reagents for modulating proliferation or differentiation in a cell or tissue comprising contacting the cell with a hedgehog agonist, such as the compounds depicted in FIGS. 32 and 33. In certain embodiments, the methods and reagents may be employed to correct or inhibit an aberrant or unwanted growth state, e.g., by antagonizing a normal ptc pathway or agonizing smoothened or hedgehog activity.
    Type: Grant
    Filed: November 28, 2000
    Date of Patent: September 2, 2003
    Assignee: Curis, Inc.
    Inventors: Jeffrey Porter, Oivin M. Guicherit, Lee Rubin, Anthony David Baxter, Edward Andrew Boyd, Stephen Price
  • Mediators of hedgehog signaling pathways, compositions and uses related thereto
    Patent number: 6552016
    Abstract: The present invention makes available methods and reagents for inhibiting aberrant growth states resulting from hedgehog gain-of-function, ptc loss-of-function or smoothened gain-of-function comprising contacting the cell with a hedgehog antagonist, such as a small molecule, in a sufficient amount to aberrant growth state, e.g., to agonize a normal ptc pathway or antagonize smoothened or hedgehog activity.
    Type: Grant
    Filed: October 13, 2000
    Date of Patent: April 22, 2003
    Assignee: Curis, Inc.
    Inventors: Anthony David Baxter, Edward Andrew Boyd, Oivin M. Guicherit, Stephen Price, Lee Rubin
  • Mediators of hedgehog signaling pathways, compositions and uses related thereto
    Patent number: 6545005
    Abstract: The present invention makes available methods and reagents for inhibiting aberrant growth states resulting from hedgehog gain-of-function by contacting the cell with a hedgehog antagonist, such as a small molecule, in a sufficient amount to aberrant growth state, e.g., to agonize a normal ptc pathway or antagonize hedgehog activity.
    Type: Grant
    Filed: September 15, 2000
    Date of Patent: April 8, 2003
    Assignee: Curtis, Inc.
    Inventors: Anthony David Baxter, Edward Andrew Boyd, Oivin M. Guicherit, Stephen Price, Lee D. Rubin
  • Small organic molecule regulators of cell proliferation
    Publication number: 20020198236
    Abstract: The present invention makes available methods and reagents for modulating proliferation or differentiation in a cell or tissue comprising contacting the cell with a hedgehog agonist, such as the compounds depicted in FIGS. 32 and 33. In certain embodiments, the methods and reagents may be employed to correct or inhibit an aberrant or unwanted growth state, e.g., by antagonizing a normal ptc pathway or agonizing smoothened or hedgehog activity.
    Type: Application
    Filed: September 26, 2001
    Publication date: December 26, 2002
    Inventors: Anthony David Baxter, Edward Andrew Boyd, Oivin M. Guicherit, Jeffery Porter, Stephen Price, Lee Rubin, John Harry Alexander Stibbard
  • Mediators of hedgehog signaling pathways, compositions and uses related thereto
    Publication number: 20020165221
    Abstract: The present invention makes available methods and reagents for inhibiting aberrant growth states resulting from hedgehog gain-of-function, ptc loss-of-function or smoothened gain-of-function comprising contacting the cell with a hedgehog antagonist, such as a small molecule, in a sufficient amount to aberrant growth state, e.g., to agonize a normal ptc pathway or antagonize smoothened or hedgehog activity.
    Type: Application
    Filed: October 12, 2001
    Publication date: November 7, 2002
    Inventors: Anthony David Baxter, Edward Andrew Boyd, Oivin M. Guicherit, Stephen Price, Lee L. Rubin