Patents by Inventor Okhil Nag

Okhil Nag has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Metal-porphyrin complexes for the inactivation of the biological activity of opioids
    Patent number: 11744834
    Abstract: A rhodium-loaded porphyrin complex, comprising the porphyrin (meso-tri(4-sulfonatophenyl) mono(4-carboxyphenyl)porphine (C1S3TPP)) with coordinated with rhodium, effectively neutralizes the biological activity of naturally-occurring and synthetic opioids.
    Type: Grant
    Filed: April 1, 2020
    Date of Patent: September 5, 2023
    Assignee: The Government of the United States of America, as represented by the Secretary of the Navy
    Inventors: Okhil Nag, Gregory Ellis, Scott Walper, Jeffrey R. Deschamps, D. Andrew Knight, James B. Delehanty
  • Cobalt-Porphyrin Complexes for the Inactivation of the Biological Activity of Opioids
    Publication number: 20220257553
    Abstract: A cobalt-loaded porphyrin complex, comprising the porphyrin (meso-tri(4-sulfonatophenyl) mono(4-carboxyphenyl)porphine (C1S3TPP)) with coordinated with cobalt, effectively neutralizes the biological activity of opioids.
    Type: Application
    Filed: February 22, 2022
    Publication date: August 18, 2022
    Inventors: Okhil Nag, D. Andrew Knight, James B. Delehanty
  • Modular, multifunctional nanoparticle-based bioconjugate for realtime visualization of cellular membrane potential
    Patent number: 11287430
    Abstract: A construct for detecting cellular membrane potential includes a nanoparticle operable as an electron donor; a modular peptide attached to the nanoparticle, the peptide comprising a nanoparticle association domain, a motif configured to mediate peptide insertion into the plasma membrane, and at least one attachment point for an electron acceptor positioned at a controlled distance from the nanoparticle; and an electron acceptor. The nanoparticle can be a quantum dot and the electron acceptor can be C60 fullerene. Emission correlates with cellular membrane potential.
    Type: Grant
    Filed: June 8, 2020
    Date of Patent: March 29, 2022
    Assignee: The Government of the United States of America, as represented by the Secretary of the Navy
    Inventors: James B. Delehanty, Michael H. Stewart, Okhil Nag, Jeffrey R. Deschamps, Kimihiro Susumu, Eunkeu Oh, Lauren D. Field, Alexander L. Efros, Alan L. Huston, Igor L. Medintz, Philip E. Dawson
  • Modular, Multifunctional Nanoparticle-Based Bioconjugate for Realtime Visualization of Cellular Membrane Potential
    Publication number: 20200355696
    Abstract: A construct for detecting cellular membrane potential includes a nanoparticle operable as an electron donor; a modular peptide attached to the nanoparticle, the peptide comprising a nanoparticle association domain, a motif configured to mediate peptide insertion into the plasma membrane, and at least one attachment point for an electron acceptor positioned at a controlled distance from the nanoparticle; and an electron acceptor. The nanoparticle can be a quantum dot and the electron acceptor can be C60 fullerene. Emission correlates with cellular membrane potential.
    Type: Application
    Filed: June 8, 2020
    Publication date: November 12, 2020
    Inventors: James B. Delehanty, Michael H. Stewart, Okhil Nag, Jeffrey R. Deschamps, Kimihiro Susumu, Eunkeu Oh, Lauren D. Field, Alexander L. Efros, Alan L. Huston, Igor L. Medintz, Philip E. Dawson
  • Metal-porphyrin complexes for the inactivation of the biological activity of opioids
    Publication number: 20200316085
    Abstract: A rhodium-loaded porphyrin complex, comprising the porphyrin (meso-tri(4-sulfonatophenyl) mono(4-carboxyphenyl)porphine (C1S3TPP)) with coordinated with rhodium, effectively neutralizes the biological activity of naturally-occurring and synthetic opioids.
    Type: Application
    Filed: April 1, 2020
    Publication date: October 8, 2020
    Inventors: Okhil Nag, Gregory Ellis, Scott Walper, Jeffrey R. Deschamps, D. Andrew Knight, James B. Delehanty
  • Multifunctional nanoparticle bioconjugates for photoacoustic-based recording of cellular membrane potential
    Patent number: 10780185
    Abstract: A construct for detecting cellular membrane potential includes a nanoparticle operable as an electron donor; a modular peptide attached to the nanoparticle, the peptide comprising a nanoparticle association domain, a motif configured to mediate peptide insertion into the plasma membrane, and at least one attachment point for an electron acceptor positioned at a controlled distance from the nanoparticle; and an electron acceptor. The nanoparticle can be a quantum dot and the electron acceptor can be C60 fullerene. Photoacoustic emission from the construct correlates with cellular membrane potential.
    Type: Grant
    Filed: July 10, 2018
    Date of Patent: September 22, 2020
    Assignee: The Government of the United States of America, as represented by the Secretary of the Navy
    Inventors: James B. Delehanty, Michael H. Stewart, Okhil Nag, Jeffrey R. Deschamps, Kimihiro Susumu, Eunkeu Oh, Lauren D. Field, Alexander L. Efros, Alan L. Huston, Igor L. Medintz, Philip E. Dawson, Nashaat Rasheed, Parag V. Chitnis, John R. Cressman
  • Zinc phthalocyanine (ZnPC) and Perylene (PY) Co-Loaded Multifunctional Nanoparticles for Photodynamic Therapy (PDT)
    Publication number: 20200215190
    Abstract: A liquid crystal nanoparticle (LCNP)-based system allows for the encapsulation and targeted delivery of Zinc (II) phthalocyanine (ZnPC) to the plasma membrane bilayer of living cells for photodynamic therapy (PDT). The formulation comprises LCNPs that are loaded in their hydrophobic core with perylene (PY) and ZnPC. In embodiments, the LCNP surface is functionalized with Poly(ethylene glycol)-cholesterol conjugates (PEG-Chol) and/or another material enabling targeting the particle to the cellular membrane. This can improve cell killing via reactive oxygen species (ROS) generation as it allows for the localized ROS-mediated peroxidation of lipids in the membrane bilayer.
    Type: Application
    Filed: February 18, 2020
    Publication date: July 9, 2020
    Inventors: Okhil Nag, Jawad Naciri, Jeff Erickson, James B. Delehanty
  • Modular, multifunctional nanoparticle-based bioconjugate for realtime visualization of cellular membrane potential
    Patent number: 10705092
    Abstract: A construct for detecting cellular membrane potential includes a nanoparticle operable as an electron donor; a modular peptide attached to the nanoparticle, the peptide comprising a nanoparticle association domain, a motif configured to mediate peptide insertion into the plasma membrane, and at least one attachment point for an electron acceptor positioned at a controlled distance from the nanoparticle; and an electron acceptor. The nanoparticle can be a quantum dot and the electron acceptor can be C60 fullerene. Emission correlates with cellular membrane potential.
    Type: Grant
    Filed: January 29, 2018
    Date of Patent: July 7, 2020
    Assignee: The Government of the United States of Americam as Represented by the Secretary of the Navy
    Inventors: James B. Delehanty, Michael H. Stewart, Okhil Nag, Jeffrey R. Deschamps, Kimihiro Susumu, Eunkeu Oh, Lauren D. Field, Alexander L. Efros, Alan L. Huston, Igor L. Medintz, Philip E. Dawson
  • Multifunctional Nanoparticle Bioconjugates for Photoacoustic-Based Recording of Cellular Membrane Potential
    Publication number: 20180326097
    Abstract: A construct for detecting cellular membrane potential includes a nanoparticle operable as an electron donor; a modular peptide attached to the nanoparticle, the peptide comprising a nanoparticle association domain, a motif configured to mediate peptide insertion into the plasma membrane, and at least one attachment point for an electron acceptor positioned at a controlled distance from the nanoparticle; and an electron acceptor. The nanoparticle can be a quantum dot and the electron acceptor can be C60 fullerene. Photoacoustic emission from the construct correlates with cellular membrane potential.
    Type: Application
    Filed: July 10, 2018
    Publication date: November 15, 2018
    Inventors: James B. Delehanty, Michael H. Stewart, Okhil Nag, Jeffrey R. Deschamps, Kimihiro Susumu, Eunkeu Oh, Lauren D. Field, Alexander L. Efros, Alan L. Huston, Igor L. Medintz, Philip E. Dawson, Nashaat Rasheed, Parag V. Chitnis, John R. Cressman
  • Modular, Multifunctional Nanoparticle-Based Bioconjugate for Realtime Visualization of Cellular Membrane Potential
    Publication number: 20180217153
    Abstract: A construct for detecting cellular membrane potential includes a nanoparticle operable as an electron donor; a modular peptide attached to the nanoparticle, the peptide comprising a nanoparticle association domain, a motif configured to mediate peptide insertion into the plasma membrane, and at least one attachment point for an electron acceptor positioned at a controlled distance from the nanoparticle; and an electron acceptor. The nanoparticle can be a quantum dot and the electron acceptor can be C60 fullerene. Emission correlates with cellular membrane potential.
    Type: Application
    Filed: January 29, 2018
    Publication date: August 2, 2018
    Inventors: James B. Delehanty, Michael H. Stewart, Okhil Nag, Jeffrey R. Deschamps, Kimihiro Susumu, Eunkeu Oh, Lauren D. Field, Alexander L. Efros, Alan L. Huston, Igor L. Medintz, Philip E. Dawson