Patents by Inventor Oksana Lockridge

Oksana Lockridge has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Butyrylcholinesterase variants and methods of use
    Patent number: 7070973
    Abstract: The invention provides four butyrylcholinesterase variants having increased cocaine hydrolysis activity as well as the corresponding encoding nucleic acids. The invention also provides libraries comprising butyrylcholinesterase variants having at least one amino acid alteration in one or more regions of butyrylcholinesterase and further having at least one butyrylcholinesterase variant exhibiting enhanced cocaine hydrolysis activity compared to butyrylcholinesterase. The invention further provides methods of hydrolyzing a cocaine-based butyrylcholinesterase substrate as well as methods of treating a cocaine-induced condition.
    Type: Grant
    Filed: December 26, 2000
    Date of Patent: July 4, 2006
    Assignees: Board of Regents of the University of Nebraska, Applied Molecular Evolution
    Inventors: Oksana Lockridge, Jeffry D. Watkins
  • Butyrylcholinesterase variants and methods of use
    Publication number: 20060063248
    Abstract: The invention provides four butyrylcholinesterase variants having increased cocaine hydrolysis activity as well as the corresponding encoding nucleic acids. The invention also provides libraries comprising butyrylcholinesterase variants having at least one amino acid alteration in one or more regions of butyrylcholinesterase and further having at least one butyrylcholinesterase variant exhibiting enhanced cocaine hydrolysis activity compared to butyrylcholinesterase. The invention further provides methods of hydrolyzing a cocaine-based butyrylcholinesterase substrate as well as methods of treating a cocaine-induced condition.
    Type: Application
    Filed: September 21, 2005
    Publication date: March 23, 2006
    Inventors: Oksana Lockridge, Jeffry Watkins
  • Butyrylcholinesterase variants and methods of use
    Publication number: 20020119489
    Abstract: The invention provides four butyrylcholinesterase variants having increased cocaine hydrolysis activity as well as the corresponding encoding nucleic acids. The invention also provides libraries comprising butyrylcholinesterase variants having at least one amino acid alteration in one or more regions of butyrylcholinesterase and further having at least one butyrylcholinesterase variant exhibiting enhanced cocaine hydrolysis activity compared to butyrylcholinesterase. The invention further provides methods of hydrolyzing a cocaine-based butyrylcholinesterase substrate as well as methods of treating a cocaine-induced condition.
    Type: Application
    Filed: December 26, 2000
    Publication date: August 29, 2002
    Inventors: Oksana Lockridge, Jeffry D. Watkins
  • Site-directed mutagenesis of esterases
    Patent number: 6001625
    Abstract: A method of modifying esterases by substitution with histadine of at least one amino acid within 6 .ANG. of an active site serine provides esterases useful for detoxifying organophasphates.
    Type: Grant
    Filed: May 19, 1995
    Date of Patent: December 14, 1999
    Assignee: The United States of America as represented by the Secretary of the Army
    Inventors: Clarence A. Broomfield, Charles B. Millard, Oksana Lockridge