Abstract: A three-plate pressure die casting mold for producing at least one metallic die casting part by die casting a metal melt, includes first, second and third mold parts and at least one mold cavity as well as a sprue system. In the third mold part there is at least one spring-loaded pressure element which, when opening the die casting mold, presses the sprue produced in the sprue system against the first mold part, whereby the sprue is retained and tears off from the die casting part in a defined manner. A method for pressure die casting using the three-plate pressure die casting mold is disclosed.

Abstract: A heat pipe having a working chamber having an evaporator region operatively connected to a heat source, and a condenser region operatively connected to a heat sink. A working fluid is provided in the working chamber, and heat is transferred from the heat source to the heat sink by the working fluid in a first state of operation. The heat pipe is a switchable and/or programmable thermal diode or a switchable and/or programmable heat switch, at least one activatable functional material is provided, which is arranged and configured to keep the evaporator region free of the working fluid and/or to prevent the working fluid from evaporating in a second state of operation, in order to reduce and/or hinder heat transfer and/or to alter the preferential direction of heat conduction. A system and method for switching and/or programming heat transfer in a heat pipe are also provided.

Abstract: A method for producing a thermoelectric module (1) having an inner tube (2), and an outer tube (8), and at least two thermoelectric base elements (5), the method including providing the thermoelectric base elements (5) outside the inner tube (2) or inside the outer tube, and widening the inner tube (2) and/or shrinking the outer tube (8). At least one plastically or elastically deformable functional layer is applied between the inner tube (2) and the thermoelectric base elements (5) and/or between the thermoelectric base elements (5) and the outer tube (8) before the widening/shrinking, and the thermoelectric base elements (5) are operatively connected to the functional layer parallel to the inner tube (2), such that an interference fit assembly is produced by the widening of the inner tube (2) and/or the shrinkage of the outer tube (8).

Abstract: A method for stabilization and/or control and/or regulation of the working temperature of a cyclic-process-based system having at least one heat-exchanger unit with at least one calorically active material element. It is essential that a base temperature of the calorically active material element (11, 12) is controlled by a cooling fluid. A heat-exchanger unit, a refrigeration machine, and a heat pump according to this are also provided.

Abstract: An exhaust-gas aftertreatment system for an internal combustion engine, having a catalyst device, which is designed to catalytically react at least one exhaust-gas component with a reactant, and a reactant-metering device, which is arranged upstream of the catalyst device along a flow path of the exhaust gas through the exhaust-gas aftertreatment system. The reactant-metering device has at least one exhaust-gas flow nozzle.

Abstract: The present invention relates to a process for the preparation of 5-fluorotryptophol as well as a process for the preparation of (1r,4r)-6?-fluoro-N,N-dimethyl-4-phenyl-4?,9?-dihydro-3?H-spiro[cyclohexane-1,1?-pyrano-[3,4b]-indol]-4-amine using the 5-fluorotryptophol obtained by said first process. The process according to the invention provides 5-fluorotryptophol in improved yield and purity without the need for chromatographic purification of the product.

Abstract: An exhaust-gas aftertreatment system for an internal combustion engine, having a catalyst device, which is designed to catalytically react at least one exhaust-gas component with a reactant, and a reactant-metering device, which is arranged upstream of the catalyst device along a flow path of the exhaust gas through the exhaust-gas aftertreatment system. The reactant-metering device has at least one exhaust-gas flow nozzle.

Abstract: The present invention relates to a process for the preparation of 5-fluorotryptophol as well as a process for the preparation of (1r,4r)-6?-fluoro-N,N-dimethyl-4-phenyl-4?,9?-dihydro-3?H-spiro[cyclohexane-1,1?-pyrano-[3,4b]-indol]-4-amine using the 5-fluorotryptophol obtained by said first process. The process according to the invention provides 5-fluorotryptophol in improved yield and purity without the need for chromatographic purification of the product.

Abstract: The present invention provides conjugates of disorazoles and their derivatives with cell-binding molecules, such as peptides, proteins, hormones, blood proteins and antibodies. The present invention further provides novel disorazole derivatives and processes of manufacturing such conjugates and disorazole derivatives. These compounds can be used as medicaments for the treatment of physiological and/or pathophysiological conditions in mammals, in particular for the treatment of various tumors.

Abstract: A process for producing 6-dimethylaminomethyl-1-(3-hydroxy- or 3-C1-C4 alkoxyphenyl)-cyclohexane-1,3-diols from 6-dimethylaminomethyl-1-hydroxy-1-(3-hydroxy- or 3-C1-C4 alkoxyphenyl)-cyclohexane-3-ones by catalytic hydrogenation in the presence of heterogeneous or homogeneous catalysts, or by using metal hydrides.

Abstract: The present invention provides conjugates of disorazoles and their derivatives with cell-binding molecules, such as peptides, proteins, hormones, blood proteins and antibodies. The present invention further provides novel disorazole derivatives and processes of manufacturing such conjugates and disorazole derivatives. These compounds can be used as medicaments for the treatment of physiological and/or pathophysiological conditions in mammals, in particular for the treatment of various tumors.

Abstract: The present invention provides conjugates of disorazoles and their derivatives with cell-binding molecules, such as peptides, proteins, hormones, blood proteins and antibodies. The present invention further provides novel disorazole derivatives and processes of manufacturing such conjugates and disorazole derivatives. These compounds can be used as medicaments for the treatment of physiological and/or pathophysiological conditions in mammals, in particular for the treatment of various tumors.

Abstract: The present invention provides conjugates of disorazoles and their derivatives with cell-binding molecules, such as peptides, proteins, hormones, blood proteins and antibodies. The present invention further provides novel disorazole derivatives and processes of manufacturing such conjugates and disorazole derivatives. These compounds can be used as medicaments for the treatment of physiological and/or pathophysiological conditions in mammals, in particular for the treatment of various tumors.

Abstract: A handpiece for a medical laser comprising an inner channel (6, 8, 8.1) into which a laser fiber (7) is fitted and protrudes with a free end portion of length (1) from a channel mouth (10), the length (1) of the laser fiber (7) protruding from the channel mouth (10) is adjustable.

Abstract: A process for producing 6-dimethylaminomethyl-1-(3-hydroxy- or 3-C1-C4 alkoxyphenyl)-cyclohexane-1,3-diols from 6-dimethylaminomethyl-1-hydroxy-1-(3-hydroxy- or 3-C1-C4 alkoxyphenyl)-cyclohexane-3-ones by catalytic hydrogenation in the presence of heterogeneous or homogeneous catalysts, or by using metal hydrides.

Abstract: The present invention provides conjugates of disorazoles and their derivatives with cell-binding molecules, such as peptides, proteins, hormones, blood proteins and antibodies. The present invention further provides novel disorazole derivatives and processes of manufacturing such conjugates and disorazole derivatives. These compounds can be used as medicaments for the treatment of physiological and/or pathophysiological conditions in mammals, in particular for the treatment of various tumors.

Abstract: The invention provides a production method for the phytoestrogen 8-Prenylnaringenin, the preparation produced by this method and the use of 8-Prenylnaringenin for the production of a medicament for the prevention and treatment of hormone-dependent osteoporosis and of peri- and postmenopausal symptoms in women.

Abstract: In a device for the automatic production of dental replacement parts, a blank 13 is fitted in a substantially plate-shaped carrier body 10 which is so dimensioned that the blank 13 does not exceed the carrier body 10 in any direction. The carrier body 10 serves not only for holding the blank 13 in the working machine but also for protecting it during its automatic handling in magazines or the like. The carrier body 10 is provided with a bar code 20 which relates to the material and dimensions of the blank 13 and may identify data according to which the blank 13 is to be worked The bar code 20 is adapted to be changed by the working machine so as to prevent the carrier body 10 from being reused with the same or a different blank 13.

Abstract: In a device for the automatic production of dental replacement parts, a blank 13 is fitted in a substantially plate-shaped carrier body 10 which is so dimensioned that the blank 13 does not exceed the carrier body 10 in any direction. The carrier body 10 serves not only for holding the blank 13 in the working machine but also for protecting it during its automatic handling in magazines or the like. The carrier body 10 is provided with a bar code 20 which relates to the material and dimensions of the blank 13 and may identify data according to which the blank 13 is to be worked. The bar code 20 is adapted to be changed by the working machine so as to prevent the carrier body 10 from being reused with the same or a different blank 13.

Abstract: A capsule holder for retaining a mixing capsule on a rotary mixing device includes a carrier plate 10, an actuator disk 11 rotatable relative to the plate, and two retaining arms 12, 13 for clamping the capsule from opposite sides, the retaining arms having driving pins 22 engaging spiral cam slots 26 of the actuator disk 11. By rotating the actuator disk 11, the retaining arms 12, 13 are moved away from, or toward, each other. The thus constituted gearing is self-locking in one direction of force transmission so that centrifugal forces exerted on the retaining arms 12, 13 during rotation cannot move the arms apart. On the other hand, the retaining arms 12, 13 are opened with little effort by rotating the actuator disk 11.