Abstract: Described is the use of a parvovirus, preferably H-1PV, for the therapeutical elimination of cancer stem cells (CSCs), preferably neuroblastoma stem cells and glioblastoma stem cells.

Abstract: A method of operating a dispensing system for a washing machine including a suds container for receiving wash liquid and at least one supply container for receiving a treating agent. The method includes selecting and activating a wash or treatment cycle from a plurality of wash or treatment cycles using an input device. The treating agent for delivery to the suds container is selected based on suitability information corresponding to the selected wash or treatment cycle. The treating agent is delivered to the suds container at the start of the activated wash or treatment cycle. The activated wash or treatment cycle is performed using a controller.

Abstract: Described is the use of a parvovirus, preferably H-1PV, for the therapeutical elimination of cancer stem cells (CSCs), preferably neuroblastoma stem cells and glioblastoma stem cells.

Abstract: Described is the use of a parvovirus, preferably H-1PV, for the therapeutical elimination of cancer stem cells (CSCs), preferably neuroblastoma stem cells and glioblastoma stem cells.

Abstract: The present invention relates to a method of identifying a subject being susceptible to a co-treatment with an histone deacetylase 10 (HDAC10)-inhibitor, said subject being in need of and/or being treated with cancer therapy against a cancer, comprising the steps of a) determining the amount of an HDAC10 gene product and/or an autophagy-related gene 4D (ATG4D) product in a cancer sample from said subject, b) comparing the amount of said HDAC10 gene product as determined in step a) with a reference amount for said HDAC10 gene product and/or the amount of ATG4D product as determined in step a) with a reference amount for said ATG4D product, and c) identifying a subject being susceptible to co-treatment with an HDAC10-inhibitor.

Abstract: Described is the use of a parvovirus, preferably H-1PV, for the therapeutical elimination of cancer stem cells (CSCs), preferably neuroblastoma stem cells and glioblastoma stem cells.

Abstract: A configuration for purification of an exhaust gas flow of an internal combustion engine includes at least one exhaust gas line having an element for exhaust gas purification with a first end face and a second end face. The exhaust gas flows through the element from the first end face to the second end face. An adding device is provided downstream of the element for adding a reactant to the exhaust gas flow. The adding device is positioned at a distance of no more than 30 mm from the second end face of the element in such a way that at least part of the added reactant strikes the second end face of the element. A method for adding a reactant into an exhaust line during the operation of an internal combustion engine is also provided.

Abstract: The present invention is concerned with the therapy of neuroblastoma and related diseases. Specifically, the present invention relates to a method for treating or preventing neuroblastoma comprising administering to a subject a therapeutically effective amount of bone morphogenetic protein 4 (BMP4). Preferably, said BMP4 is applied together with chemotherapy and/or radiation therapy.

Abstract: A dispensing system for powdered treating agent for use in a washing machine includes a supply container for the treating agent, a delivery device configured to deliver the treating agent to the washing machine through a connecting hose, and a dosing device for dispensing the treating agent from the supply container to the delivery device. The supply container has an agitator with a first vertical rotatable shaft and rotatable blades. The dosing device includes a cylindrical chamber, with a compartmented wheel having spokes disposed therein. The compartmented wheel is disposed below a bottom of the supply container and is coupled to a second vertical rotatable shaft. The cylindrical chamber has an inlet opening disposed in the bottom of the supply container and an underside of the cylindrical chamber has an outlet opening to the delivery device. The compartmented wheel is also coupled to the vertical shaft of the agitator.

Abstract: A treating agent dispensing system for a washing machine including a base unit and at least two supply containers removably and securably disposed on the base unit. The at least two supply containers are respectively configured to receive a treating agent. The treating agent is a powdered treating agent or a liquid treating agent. A delivery device is disposed in the base unit and is operable to deliver the treating agent to the washing machine through a hose.

Abstract: The present invention is concerned with the therapy of neuroblastoma and related diseases. Specifically, the present invention relates to a method for treating or preventing neuroblastoma comprising administering to a subject a therapeutically effective amount of bone morphogenetic protein 4 (BMP4). Preferably, said BMP4 is applied together with chemotherapy and/or radiation therapy.

Abstract: A method for adding at least one, in particular liquid, reactant, to an exhaust gas stream of an internal combustion engine includes adding a reactant flow to the stream downstream of an element provided for an at least partial conversion and/or at least partial elimination of at least one component of the stream, so that at least part of the reactant flow impinges on the element. This achieves rapid evaporation of the reactant flow. Impinging on the element, which is hot during operation, i.e. at temperatures of 400° C. and more, causes rapid evaporation and, because of a preferably porous coating of the element, take-up of the reactant solution into the element with successive evaporation. Urea, in particular, can be evaporated quickly, effectively and virtually completely upon introduction into an exhaust system as a reducing agent for selective catalytic reduction of nitrogen oxides, in particular in a downstream SCR catalytic converter.

Abstract: A method of operating a dispensing system for a washing machine including a suds container for receiving wash liquid and at least one supply container for receiving a treating agent. The method includes selecting and activating a wash or treatment cycle from a plurality of wash or treatment cycles using an input device. The treating agent for delivery to the suds container is selected based on suitability information corresponding to the selected wash or treatment cycle. The treating agent is delivered to the suds container at the start of the activated wash or treatment cycle. The activated wash or treatment cycle is performed using a controller.

Abstract: A treating agent dispensing system for a washing machine including a base unit and at least two supply containers removably and securably disposed on the base unit. The at least two supply containers are respectively configured to receive a treating agent. The treating agent is a powdered treating agent or a liquid treating agent. A delivery device is disposed in the base unit and is operable to deliver the treating agent to the washing machine through a hose.

Abstract: A dispensing system for powdered treating agent for use in a washing machine. The dispensing system includes at least one supply container with a fill opening for the powdered treating agent, an agitator having a vertical rotatable shaft and blades or vanes configured to be rotated by the rotatable shaft, and a contact protection grill configured to cover the fill opening so as to prevent contact with the agitator. The agitator is drivable by an electrical drive.

Abstract: A dispensing system for powdered treating agent for use in a washing machine. The dispensing system includes at least one supply container for the treating agent, a delivery device configured to deliver the treating agent to the washing machine through a connecting hose and a dosing device for dispensing the treating agent from the supply container to the delivery device. The supply container has an agitator with a first vertical rotatable shaft and blades configured to be rotated by the first vertical rotatable shaft. The agitator is drivable by an electric drive. The dosing device includes a cylindrical chamber and a compartmented wheel disposed therein. The compartmented wheel has a plurality of compartments separated by spokes. The compartmented wheel is disposed below a bottom of the supply container and is coupled to a second vertical rotatable shaft. The cylindrical chamber has an inlet opening disposed in the bottom of the supply container and is configured to fill the compartments therethrough.

Abstract: The present invention relates to uses of compounds having a structure as shown by formula (I) for the manufacture of a pharmaceutical composition for the treatment of neuroblastoma. Moreover, the present invention encompasses methods of treatment for said diseases.

Abstract: A method for adding at least one, in particular liquid, reactant, to an exhaust gas stream of an internal combustion engine includes adding a reactant flow to the stream downstream of an element provided for an at least partial conversion and/or at least partial elimination of at least one component of the stream, so that at least part of the reactant flow impinges on the element. This achieves rapid evaporation of the reactant flow. Impinging on the element, which is hot during operation, i.e. at temperatures of 400° C. and more, causes rapid evaporation and, because of a preferably porous coating of the element, take-up of the reactant solution into the element with successive evaporation. Urea, in particular, can be evaporated quickly, effectively and virtually completely upon introduction into an exhaust system as a reducing agent for selective catalytic reduction of nitrogen oxides, in particular in a downstream SCR catalytic converter.