Patents by Inventor Olay Smidsrod

Olay Smidsrod has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Cells encapsulated in alginate containing a high content of a- l- guluronic acid
    Patent number: 5459054
    Abstract: Cells such as mammalian or genetically modified cells are encapsulated in high-G alginate that provokes reduced immune response during transplantation or implantation. The alginate contains greater than 50% .alpha.-L-guluronic acid and a minimal amount of mannuronic acid. The amount of .alpha.-L-guluronic acid is preferably at least 65% and more preferably at least 85%. Encapsulation is carried out by suspending cells in a solution of the high-G alginate, forming drops of the solution and contacting the drops with calcium ions to gel the alginate and form microcapsules containing the cells. The microcapsules may contain multiple layers with the high-G alginate preferably forming the outermost layer.
    Type: Grant
    Filed: July 2, 1993
    Date of Patent: October 17, 1995
    Assignee: Neocrin Company
    Inventors: Gudmund Skjak-Braek, Olay Smidsrod, Terje Espevik, Marit Otterlei, Patrick Soon-Shiong