Abstract: Provided is a method of treating patients with cluster headache comprising intranasal administration to a patient in need thereof of an aqueous composition, e.g., pharmaceutical composition, comprising a therapeutically effective amount of ketamine, a method of reducing or eliminating side effects of ketamine when used in the treatment of Cluster headache, and to a composition, e.g., pharmaceutical composition, comprising a therapeutically effective amount of ketamine for use in the treatment of cluster headache, wherein the composition is in a nasal dosage form such as a nasal spray.

Abstract: Provided is a method of treating patients with Cluster Headache (CH) including chronic Cluster Headache (cCH) comprising intranasal administration to a patient in need thereof of an aqueous composition, e.g., pharmaceutical composition, comprising a therapeutically effective amount of ketamine, which may reduce or eliminate side effects of ketamine when used in the treatment of Cluster Headache, and to a composition, e.g., pharmaceutical composition, comprising a therapeutically effective amount of ketamine for use in the treatment of Cluster Headache, wherein the composition is in a nasal dosage form such as a nasal spray.

Abstract: A flushable biodegradable pouch having water-dispersible fibers along at least a portion of the outer surface of the pouch's cover layer provided with a water-soluble hydrophilic coating. The pouch's cover layer is water-disintegratable, and the water-soluble hydrophilic coating is a lubricating agent capable of becoming slippery when exposed to water and, upon subsequent drying, again becoming water-soluble upon re-exposure to water. As such, the hydrophilic coating serves as a rewettable, redesolving lubricating agent.

Abstract: An ostomy appliance having a face plate assembly and inner and outer pouches joined thereto, has its outer pouch provided with one or more peripherally-extending sealing seams that allow the walls of the outer pouch to be separated by peeling forces applied in directions transverse to such seam or seams. In preferred embodiments, the sealing seam, also peelably join the peripheral edges of the outer pouch to those of the inner pouch. A method of disposing of the pouch assembly of such an ostomy appliance is also disclosed.

Abstract: An ostomy appliance is provided with inner and outer pouches separably joined together by peelable seams. A vent passage and deodorising filter are also provided, most advantageously located externally of the pouches, and a pre-filter is preferably positioned in advance of the deodorising filter.

Abstract: An ostomy appliance having a face plate assembly and inner and outer pouches joined thereto, has its outer pouch provided with one or more peripherally-extending sealing seams that allow the walls of the outer pouch to be separated by peeling forces applied in directions transverse to such seam or seams. In preferred embodiments, the sealing seam, also peelably join the peripheral edges of the outer pouch to those of the inner pouch. A method of disposing of the pouch assembly of such an ostomy appliance is also disclosed.

Abstract: An ostomy appliance having a face plate assembly and inner and outer pouches joined thereto, has its outer pouch provided with one or more peripherally-extending sealing seams that allow the walls of the outer pouch to be separated by peeling forces applied in directions transverse to such seam or seams. In preferred embodiments, the sealing seam, also peelably join the peripheral edges of the outer pouch to those of the inner pouch. A method of disposing of the pouch assembly of such an ostomy appliance is also disclosed.

Abstract: A flushable biodegradable pouch having water-dispersible fibers along at least a portion of the outer surface of the pouch's cover layer provided with a water-soluble hydrophilic coating. The pouch's cover layer is water-disintegratable, and the water-soluble hydrophilic coating is a lubricating agent capable of becoming slippery when exposed to water and, upon subsequent drying, again becoming water-soluble upon re-exposure to water. As such, the hydrophilic coating serves as a rewettable, redesolving lubricating agent.

Abstract: An ostomy appliance is provided with inner and outer pouches separably joined together by peelable seams. A vent passage and deodorising filter are also provided, most advantageously located externally of the pouches, and a pre-filter is preferably positioned in advance of the deodorising filter.

Abstract: An ostomy appliance is provided with inner and outer pouches separably joined together by peelable seams. A vent passage and deodorizing filter are also provided, most advantageously located externally of the pouches, and a pre-filter is preferably positioned in advance of the deodorizing filter.

Abstract: An ostomy appliance comprising an adhesive face plate comprising an adhesive layer 2, a release sheet 3 and a carrier sheet 4 attached to a coupling ring 6 by means of a plastic film strip 9 forming a filter pouch together with a film strip 12 having a flatus gas venting aperture 18 covered by a filter 17, the filter pouch 9, 12 communicating through an aperture 20 in the film 9 with the interior of an ostomy bag 6b attached to the face plate by means of a coupling ring 6a engaging the coupling ring 6, an intermediate film 21 subdividing the filter pouch 9, 12 into two compartments 22 and 23 in flow communication through an aperture 24 in the film 21, the filter 17 being located in the compartment 23 such flatus gas flows from the interior of the bag 6b through aperture 20 into compartment 22, through aperture 24 into compartment 23, through filter 17 and out through aperture 18.

Abstract: An ostomy appliance is provided with inner and outer pouches separably joined together by peelable seams. A vent passage and deodorising filter are also provided, most advantageously located externally of the pouches, and a pre-filter is preferably positioned in advance of the deodorising filter.

Abstract: An ostomy appliance having a face plate assembly and inner and outer pouches joined thereto, has its outer pouch provided with one or more peripherally-extending sealing seams that allow the walls of the outer pouch to be separated by peeling forces applied in directions transverse to such seam or seams. In preferred embodiments, the sealing seam, also peelably join the peripheral edges of the outer pouch to those of the inner pouch. A method of disposing of the pouch assembly of such an ostomy appliance is also disclosed.

Abstract: A method for producing a soft convex adhesive wafer for attaching an ostomy appliance to a peristomal skin surface surrounding a stoma. In one embodiment, the method includes providing a resilient laminating pad adapted for being displaced to and fro in a laminating direction and that exerts a laminating pressure in the laminating direction, providing a plane counter-pressure surface at substantially right angles to the laminating direction, placing the wafer on the counter-pressure surface, and displacing the laminating pad in the laminating direction so that laminating pressure is exerted on an entire distal surface of the wafer by the laminating pad.

Abstract: An adhesive wafer for attaching an ostomy appliance to a peristomal skin surface surrounding a stoma has an integrally molded adhesive layer made of a skin barrier material, a distal surface covered by a flexible backing layer, and a proximal bodyside surface contoured so the adhesive layer has a thin peripheral portion and thick central portion surrounding a stoma-receiving aperture. A set of at least two wafers is provided in one embodiment, wherein individual wafers have differing central portion surface topography, and different stoma receiving apertures. To produce a closely fitting wafer for a given stoma, a method of producing wafers includes providing a representation of the topography of the peristomal surface and the stoma, and, using the representation, manufacturing a mold having a surface configuration substantially matching the topography of the peristomal surface and stoma.

Abstract: The invention relates to a method and a microsensor for measurement of transport coefficients like diffusivity or flow velocity. The microsensor has a reservoir provided with a mouth and a transducer. The transducer has a tip placed in the mouth, which can be provided with a membrane or insert. The reservoir contains one or more gases or one or more liquid-dissolved substances intended for the diffusion through the mouth into an area or field of a medium outside the mouth of the reservoir. The transducer measures the partial pressure of the gas or the concentration of the liquid-dissolved substance in the mouth, whereby transport coefficients of diffusivity or flow velocity are determined. Preferably, the gradient of the partial pressure or the concentration is determined.