Patents by Inventor Oleg Gang
Oleg Gang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240013852Abstract: The disclosed matter provides systems and methods for encoding an assembly of three-dimensional (3D) hierarchically ordered nanoparticle architectures through chromatic bonds. Through identification of the repeating mesovoxels including chromatic bonds and voxels, the presented disclose matter can allow for encoding the 3D architectures by using symmetries of mesovoxel, enable a compression of the information amount required for encoding.Type: ApplicationFiled: July 3, 2023Publication date: January 11, 2024Inventors: Oleg GANG, Brian MINEVICH, Hamed EMAMY, Shuting XIANG, Jason S. KAHN, Aaron MICHELSON, Kim KISSLINGER, Sanat KUMAR
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Patent number: 11866775Abstract: The present method of detection involves increasing an amount of analyte molecules by an isothermal molecular amplification approach. In the present approach a starting molecule of interest may be amplified through a reaction it induces with specifically engineered and functionalized particles, namely protected particles A and storage particles B. This reaction may result in a set of output DNA molecules that is larger in number than the input DNA molecules. Thus the reaction between nanoparticles for amplification of a certain DNA sequence (input DNA molecules) may occur when there is a match with a targeted molecule (stored molecules on storage particles B) and if the DNA sequence of the input DNA molecules does not match (partially or completely) the targeted molecule the reaction may not occur. Without a certain molecular input of the input DNA molecule the reaction may not occur.Type: GrantFiled: October 7, 2020Date of Patent: January 9, 2024Assignee: Brookhaven Science Associates, LLCInventors: Oleg Gang, Suchetan Pal
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Patent number: 11739162Abstract: The current invention pertains compositions and methods to generate compositions providing stability to biomolecules, including providing physiologically stable and functional DNA origami-based drug/gene delivery carriers by surface coating with the oligo-ethylene glycol conjugated peptoids of Formulas (I), (II), and (III).Type: GrantFiled: September 9, 2020Date of Patent: August 29, 2023Assignees: Brookhaven Science Associates LLC, The Board of Trustees of the Leland Stanford Junior University, The Regents of the University of California, The Trustees of Columbia University in the City of New YorkInventors: Shih-Ting Wang, Oleg Gang, Ronald N. Zuckermann, Carolyn R. Bertozzi
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Publication number: 20220365000Abstract: An apparatus includes a main body, circuit assembly, lens, and clamping assembly. The main body includes an aperture that receives a wafer configured to receive a sample under study. The main body is configured to support the circuit assembly, which includes illumination sources that emit light of different colors such that total internal reflection is generated in the wafer. The main body is configured to provide support for the lens, and the clamping assembly mechanically coupled to the main body such that the lens is selectively positionable with respect to a camera lens. A microscopy imaging apparatus includes an illumination source, wafer, and charge-coupled device. The illumination source is configured to emit white light such that total internal reflection is generated in the wafer.Type: ApplicationFiled: May 16, 2022Publication date: November 17, 2022Inventors: Mingzhao Liu, Justine E. Haupt, Connie-Rose Mai Deane, Oleg Gang
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Publication number: 20210264663Abstract: The present subject matter relates to a voxel and methods of organizing an object into a three-dimensional (3D) array using the voxel. The voxel can include a plurality of frames including at least one single stranded (ss) DNA motif with at least one free base, wherein the at least one ssDNA motif hybridizes with a complementary strand fragment of other frames.Type: ApplicationFiled: October 14, 2020Publication date: August 26, 2021Applicant: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORKInventors: Oleg Gang, Ye Tian, Jason S. Kahn, Yan Xiong, Brian Minevich, Sanat K. Kumar
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Publication number: 20210070886Abstract: The current invention pertains compositions and methods to generate compositions providing stability to biomolecules, including providing physiologically stable and functional DNA origami-based drug/gene delivery carriers by surface coating with the oligo-ethylene glycol conjugated peptoids of Formulas (I), (II), and (III).Type: ApplicationFiled: September 9, 2020Publication date: March 11, 2021Inventors: Shih-Ting Wang, Oleg Gang, Ronald N. Zuckermann, Carolyn R. Bertozzi
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Publication number: 20210024990Abstract: The present method of detection involves increasing an amount of analyte molecules by an isothermal molecular amplification approach. In the present approach a starting molecule of interest may be amplified through a reaction it induces with specifically engineered and functionalized particles, namely protected particles A and storage particles B. This reaction may result in a set of output DNA molecules that is larger in number than the input DNA molecules. Thus the reaction between nanoparticles for amplification of a certain DNA sequence (input DNA molecules) may occur when there is a match with a targeted molecule (stored molecules on storage particles B) and if the DNA sequence of the input DNA molecules does not match (partially or completely) the targeted molecule the reaction may not occur. Without a certain molecular input of the input DNA molecule the reaction may not occur.Type: ApplicationFiled: October 7, 2020Publication date: January 28, 2021Inventors: Oleg Gang, Suchetan Pal
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Publication number: 20180340217Abstract: The present method of detection involves increasing an amount of analyte molecules by an isothermal molecular amplification approach. In the present approach a starting molecule of interest may be amplified through a reaction it induces with specifically engineered and functionalized particles, namely protected particles A and storage particles B. This reaction may result in a set of output DNA molecules that is larger in number than the input DNA molecules. Thus the reaction between nanoparticles for amplification of a certain DNA sequence (input DNA molecules) may occur when there is a match with a targeted molecule (stored molecules on storage particles B,) and if the DNA sequence of the input DNA molecules does not match (partially or completely) the targeted molecule the reaction may not occur. Without a certain molecular input of the input DNA molecule the reaction may not occur.Type: ApplicationFiled: May 18, 2018Publication date: November 29, 2018Inventors: Oleg Gang, Suchetan Pal
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Patent number: 9751758Abstract: A method for lattice design via multivalent linkers (LDML) is disclosed that introduces a rationally designed symmetry of connections between particles in order to achieve control over the morphology of their assembly. The method affords the inclusion of different programmable interactions within one linker that allow an assembly of different types of particles. The designed symmetry of connections is preferably provided utilizing DNA encoding. The linkers may include fabricated “patchy” particles, DNA scaffold constructs and Y-shaped DNA linkers, anisotropic particles, which are preferably functionalized with DNA, multimeric protein-DNA complexes, and particles with finite numbers of DNA linkers.Type: GrantFiled: January 18, 2013Date of Patent: September 5, 2017Assignee: Brookhaven Science Associates, LLCInventors: Oleg Gang, Fang Lu, Miho Tagawa
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Publication number: 20160176988Abstract: The bio-programmable crystallization of multi-component functional nanoparticle systems is described, as well as methods for such bio-programmable crystallization, and the products resultant from such methods. Specifically, the systems disclosed and taught herein are directed to improved strategies for the DNA-mediated self-assembly of multi-component functionalized nanoparticles into three-dimensional order superlattices, wherein the functionalization of the nanoparticles with DNA is independent of either the composition of the material, or the shape of the nanoparticles.Type: ApplicationFiled: October 7, 2015Publication date: June 23, 2016Inventors: Yugang Zhang, Fang Lu, Daniel van der Lelie, Oleg Gang
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Publication number: 20150017444Abstract: A method for lattice design via multivalent linkers (LDML) is disclosed that introduces a rationally designed symmetry of connections between particles in order to achieve control over the morphology of their assembly. The method affords the inclusion of different programmable interactions within one linker that allow an assembly of different types of particles. The designed symmetry of connections is preferably provided utilizing DNA encoding. The linkers may include fabricated “patchy” particles, DNA scaffold constructs and Y-shaped DNA linkers, anisotropic particles, which are preferably functionalized with DNA, multimeric protein-DNA complexes, and particles with finite numbers of DNA linkers.Type: ApplicationFiled: January 18, 2013Publication date: January 15, 2015Inventors: Oleg Gang, Fang Lu, Miho Tagawa
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Publication number: 20140308520Abstract: The bio-programmable crystallization of multi-component functional nanoparticle systems is Ascribed, as well as methods for such bio-programmable crystallization, and the products resultant from such methods. Specifically, the systems disclosed and taught herein are directed to improved strategies for the DNA-mediated self-assembly of multi-component functionalized nanoparticles into three-dimensional order surperlattices, wherein the functionalization of the nanoparticles with DNA is independent of either the composition of the material, or the shape of the nanoparticles.Type: ApplicationFiled: April 12, 2012Publication date: October 16, 2014Applicant: BROOKHAVEN SCIENCE ASSOCIATES, LLCInventors: Yugang Zhang, Fang Lu, Oleg Gang, Daniel Van Der Lelie
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Patent number: 8729012Abstract: The invention relates to the use of peptides, proteins, and other oligomers to provide a means by which normally quenched nanoparticle fluorescence may be recovered upon detection of a target molecule. Further, the inventive technology provides a structure and method to carry out detection of target molecules without the need to label the target molecules before detection. In another aspect, a method for forming arbitrarily shaped two- and three-dimensional protein-mediated nanoparticle structures and the resulting structures are described. Proteins mediating structure formation may themselves be functionalized with a variety of useful moieties, including catalytic functional groups.Type: GrantFiled: June 2, 2009Date of Patent: May 20, 2014Assignee: Brookhaven Science Associates, LLCInventors: Soo-Kwan Lee, Oleg Gang, Daniel van der Lelie
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Publication number: 20140106258Abstract: Truncated ditetragonal gold prisms (Au TDPs) are synthesized by adding a dilute solution of gold seeds to a growth solution, and allowing the growth to proceed to completion. The Au TDPs exhibit the face-centered cubic crystal structure and are bounded by 12 high-index {310} facets. The Au TDPs may be used as heterogeneous catalysts as prepared, or may be used as substrates for subsequent deposition of an atomically thin layer of a platinum group metal catalyst. When the Au TDPs are used as substrates, the atomically thin layer of metal reproduces the high-index facets of the Au TDPs.Type: ApplicationFiled: October 15, 2013Publication date: April 17, 2014Applicant: Brookhaven Science Associates, LLCInventors: Fang Lu, Oleg Gang, Yugang Zhang, Yu Zhang, Jia X. Wang
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Publication number: 20130261292Abstract: In some embodiments, DNA-capped nanoparticles are used to define a degree of crystalline order in assemblies thereof. In some embodiments, thermodynamically reversible and stable body-centered cubic (bcc) structures, with particles occupying <˜10% of the unit cell, are formed. Designs and pathways amenable to the crystallization of particle assemblies are identified. In some embodiments, a plasmonic crystal is provided. In some aspects, a method for controlling the properties of particle assemblages is provided. In some embodiments a catalyst is formed from nanoparticles linked by nucleic acid sequences and forming an open crystal structure with catalytically active agents attached to the crystal on its surface or in interstices.Type: ApplicationFiled: June 12, 2013Publication date: October 3, 2013Inventors: OLEG GANG, DMYTRO NYKYPANCHUK, MATTHEW MAYE, DANIEL VAN DER LELIE
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Patent number: 8487084Abstract: In some embodiments, DNA-capped nanoparticles are used to define a degree of crystalline order in assemblies thereof. In some embodiments, thermodynamically reversible and stable body-centered cubic (bcc) structures, with particles occupying <˜10% of the unit cell, are formed. Designs and pathways amenable to the crystallization of particle assemblies are identified. In some embodiments, a plasmonic crystal is provided. In some aspects, a method for controlling the properties of particle assemblages is provided. In some embodiments a catalyst is formed from nanoparticles linked by nucleic acid sequences and forming an open crystal structure with catalytically active agents attached to the crystal on its surface or in interstices.Type: GrantFiled: April 3, 2009Date of Patent: July 16, 2013Assignee: Brookhaven Science Associates, LLCInventors: Oleg Gang, Dmytro Nykypanchuk, Mathew Maye, Daniel van der Lelie
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Publication number: 20130137602Abstract: The present invention is directed to nanoscale fabrication of nano-materials with application in electronics, energy conversion, bio-sensing and others. Specifically, the invention is directed to arbitrary, that is periodic and non-periodic, assembly of nano-objects on I D and 2D arrays. The present invention utilizes self-organization properties of nanoscale bio-encoded building blocks, programmability of biomolecular interactions, and simple processing techniques for providing arbitrary by-design fabrication capability. Specifically, the present invention utilizes double stranded DNA attached to a surface and intercalating PNA-DNA hybrids attached to nano-objects to bind the nano-objects to the dsDNA in a site specific manner. The present invention allows for an integration of a large number of nano-components in unified well-defined systems.Type: ApplicationFiled: March 7, 2011Publication date: May 30, 2013Applicant: Brookhaven Science Associates, LLCInventors: Oleg Gang, Daniel van der Lelie
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Publication number: 20120141797Abstract: The disclosure is directed to nanoparticles used in creating nanostructure complexes in the presence of divalent cations. In particular, the disclosure is directed to nanoparticles that are coated with zwitterions and linker portions in a manner that facilitates nanostructure complex assembly while reducing or preventing non-specific spontaneous aggregation of nanoparticle in the presence of divalent cations. The disclosure also provides a method for preparing a nanoparticle coating of the present invention. Furthermore, the disclosure provides a method for assembling nanostructure complexes using coated nanoparticles with a scaffold.Type: ApplicationFiled: April 20, 2011Publication date: June 7, 2012Applicant: Brookhaven Science Associates, LLCInventors: William B. Sherman, Thilak K. Mudalige, Oleg Gang
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Publication number: 20110196130Abstract: The invention relates to the use of peptides, proteins, and other oligomers to provide a means by which normally quenched nanoparticle fluorescence may be recovered upon detection of a target molecule. Further, the inventive technology provides a structure and method to carry out detection of target molecules without the need to label the target molecules before detection. In another aspect, a method for forming arbitrarily shaped two- and three-dimensional protein-mediated nanoparticle structures and the resulting structures are described. Proteins mediating structure formation may themselves be functionalized with a variety of useful moieties, including catalytic functional groups.Type: ApplicationFiled: June 2, 2009Publication date: August 11, 2011Applicant: BROOKHAVEN SCIENCE ASSOCIATESInventors: Soo-kwan Lee, Oleg Gang, Daniel van der lelie
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Publication number: 20090275465Abstract: In some embodiments, DNA-capped nanoparticles are used to define a degree of crystalline order in assemblies thereof. In some embodiments, thermodynamically reversible and stable body-centered cubic (bcc) structures, with particles occupying <˜10% of the unit cell, are formed. Designs and pathways amenable to the crystallization of particle assemblies are identified. In some embodiments, a plasmonic crystal is provided. In some aspects, a method for controlling the properties of particle assemblages is provided. In some embodiments a catalyst is formed from nanoparticles linked by nucleic acid sequences and forming an open crystal structure with catalytically active agents attached to the crystal on its surface or in interstices.Type: ApplicationFiled: April 3, 2009Publication date: November 5, 2009Applicant: Brookhaven Science Associates, LLCInventors: Oleg Gang, Dmytro Nykypanchuk, Mathew Maye, Daniel van der Lelie