Abstract: A peptide compound and composition useful for binding to amyloid-? peptides and/or preventing or reducing the formation of amyloid plaques, especially by inhibiting polymerization of the amyloid peptide in the form of amyloid plaques, and a method of treatment of a disease in which the formation of amyloid plaques occurs.

Abstract: A peptide compound of the following general formula (I) or (II): Ra—R1—R2—R3—R4—Rb??(I) or Ra—R4—R3—R2—R1—Rb??(II) wherein, R1 is a residue of amino acid H, R or K; R2 is a residue of amino acid A; R3 is a residue of amino acid E or D; R4 is a residue of amino acid E or D, Ra represents the N-terminal primary amine functions of the amino acid R1 or R4, either free or substituted with a protective group, Rb represents the hydroxyl function of the C-terminal carboxyl group of the amino acid R1 or R4, either free or substituted with a protective group.