Patents by Inventor Oleg N. Ekzemplyarov

Oleg N. Ekzemplyarov has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • N,N,N-Trimethyl derivatives of polyene amphoteric antibiotics, process of producing same and pharmaceutical composition
    Patent number: 4144328
    Abstract: The present invention relates to novel substances; namely, to N,N,N-trimethyl derivatives of polyene amphoteric antibiotics, and to a process of producing same, said substances having the following general formula: ##STR1## wherein R is aglycone of a polyene amphoteric antibiotic, without the carboxyl group.The process of producing N,N,N-trimethyl derivatives of polyene amphoteric antibiotics is carried out in an organic solvent medium wherein said polyene amphoteric antibiotics are subjected to complete amino-group methylation by means of a methylating agent with subsequent separation of the end product. N,N,N-trimethyl derivatives of polyene amphoteric antibiotics possess high antibiotic activity thus inhibiting the growth of yeast, yeast-like microorganisms, and filamentous fungi. Said compounds are used in medicine to treat fungal diseases.
    Type: Grant
    Filed: February 28, 1977
    Date of Patent: March 13, 1979
    Inventors: Viktor A. Vainshtein, Valter O. Kulbakh, Evgeny D. Etingov, Grigory N. Naumchik, Oleg N. Ekzemplyarov, Georgy A. Mikhailets, Grigory E. Grinberg, Alla N. Egorenkova