Abstract: Various approaches of focusing an ultrasound transducer having multiple transducer elements to a target region include generating at least one acoustic reflector in the target region; transmitting ultrasound waves to the acoustic reflector; measuring reflections off the acoustic reflector; and based at least in part on the measured reflections, adjusting the parameter value associated with the transducer element(s).

Abstract: Various approaches for focusing an ultrasound transducer having multiple transducer elements include causing the transducer elements to transmit ultrasound waves to a first one or more target regions and measure reflections of the ultrasound waves off the first one or more target regions; and based at least in part on the measured reflections, determining a parameter value associated with at least one of the transducer elements so as to generate an ultrasound focus at a second target region, different from the first one or more target regions.

Abstract: Various approaches of focusing an ultrasound transducer having multiple transducer elements to a target region include generating at least one acoustic reflector in the target region; transmitting ultrasound waves to the acoustic reflector; measuring reflections off the acoustic reflector; and based at least in part on the measured reflections, adjusting the parameter value associated with the transducer element(s).

Abstract: Various approaches for focusing an ultrasound transducer having multiple transducer elements include causing the transducer elements to transmit ultrasound waves to a target region and measure reflections of the ultrasound waves off the target region; for each of at least some of the transducer elements, adjusting a parameter value associated with said each transducer element based at least in part on parameter values associated with multiple measuring transducer elements weighted by signal quality metrics associated with the reflections measured by the measuring transducer elements so as to improve an ultrasound focus at the target region.

Abstract: Various approaches for focusing an ultrasound transducer include introducing at least one transient acoustic reflector located in proximity to at least one target region; generating multiple sonications to the at least one target region; measuring a reflection signal of each of the sonications off the at least one transient acoustic reflector; selecting the measured reflection signals, and based at least in part on the selected reflection signals, adjusting a parameter value associated with at least one of the transducer elements so as to improve an ultrasound focus at the target region.

Abstract: Various approaches to focusing an ultrasound transducer includes causing the ultrasound transducer to transmit ultrasound waves to the target region; causing the detection system to indirectly measure the focusing properties; and based at least in part on the indirectly measured focusing properties, adjusting a parameter value associated with at least one of the transducer elements so as to achieve a target treatment power at the target region.

Abstract: Embodiments of the present invention provide systems and methods to detect a moving anatomic feature during a treatment sequence based on a computed and/or a measured shortest distance between the anatomic feature and at least a portion of an imaging system.

Abstract: Various approaches for calibrating the geometry of an ultrasound transducer having multiple transducer elements include providing an acoustic reflector spanning an area traversing by multiple beam paths of ultrasound waves transmitted from all (or at least some) transducer elements to a focal zone; causing the transducer elements to transmit the ultrasound waves to the focal zone; measuring reflections of the ultrasound waves off the acoustic reflector; and based at least in part on the measured reflections, determining optimal geometric parameters associated with the transducer elements.

Abstract: Embodiments of the present invention provide systems and methods to detect a moving anatomic feature during a treatment sequence based on a computed and/or a measured shortest distance between the anatomic feature and at least a portion of an imaging system.

Abstract: Various approaches for calibrating the geometry of an ultrasound transducer having multiple transducer elements include providing an acoustic reflector spanning an area traversing by multiple beam paths of ultrasound waves transmitted from all (or at least some) transducer elements to a focal zone; causing the transducer elements to transmit the ultrasound waves to the focal zone; measuring reflections of the ultrasound waves off the acoustic reflector; and based at least in part on the measured reflections, determining optimal geometric parameters associated with the transducer elements.

Abstract: Various approaches for detecting microbubble cavitation resulting from ultrasound waves transmitted from an ultrasound transducer include associating at least one time-domain reference signal with microbubble cavitation; causing the transducer to transmit one or more ultrasound pulse; acquiring, in the time domain, an echo signal from microbubbles in response to the transmitted ultrasound pulse(s); correlating at least a portion of the echo signal to at least a corresponding portion of the time-domain reference signal based on similarity therebetween; and detecting the microbubble cavitation based on the corresponding portion of the reference signal.

Abstract: Embodiments of the present invention provide systems and methods to verify and/or obtain a registration of images obtained two image systems (such as a CT system and an MRI system) via the use of a third imaging modality (such as an ultrasound system).

Abstract: Embodiments of the present invention provide systems and methods to verify and/or obtain a registration of images obtained two image systems (such as a CT system and an MRI system) via the use of a third imaging modality (such as an ultrasound system).

Abstract: A multilayer ultrasound transducer is used to provide high output power with a desired transmission and reception frequency response profile.

Abstract: Systems and methods for focusing ultrasound through the skull into the brain for diagnostic or therapeutic purposes may be improved by utilizing both longitudinal and shear waves. The relative contribution of the two modes may be determined based on the angle of incidence.

Abstract: Ultrasound energy is delivered to a patient in a controlled manner using a focused ultrasound system, thus maintaining the desired therapeutic effect without causing unwanted damage to surrounding tissue. An ultrasound transducer device includes multiple transducer elements, each of which is controlled by drive circuitry and a drive signal controller. An acoustic detector detects signals indicative of cavitation in tissue targeted by the transducer elements, and the drive signal controller manages the delivery of acoustic energy from the transducer elements based on the detected cavitation signals such that a therapeutic effect at the target tissue remains within an efficacy range.

Abstract: Systems and methods for focusing ultrasound through the skull into the brain for diagnostic or therapeutic purposes may be improved by utilizing both longitudinal and shear waves. The relative contribution of the two modes may be determined based on the angle of incidence.

Abstract: The emission intensities of groupings of transducer elements of an ultrasound transducer array are controlled based on targeting criteria in such a manner as to simultaneously create multiple discontiguous foci, each corresponding to one of a plurality of target sites.

Abstract: An ultrasound transducer comprises a multiplicity of piezoelectric transducer elements attached to a backing layer and forming a two-dimensional array, the transducer elements each comprising one or more piezoelectric members that collectively form an energy transmitting surface of the respective transducer element, the energy transmitting surface having a geometric center, wherein the respective transducer element geometric centers are in an irregular formation.

Abstract: Method for adjusting the output of a phased array ultrasonic transducer using surface mapping. The transducer surface is mapped using a sensor, such as a hydrophone, to determine the actual location of each transducer element relative to the expected location of each transducer element. Mapping can be performed by measuring a distance between a hydrophone and each transducer element. At least one of the hydrophone and the transducer are moveable relative to each other to map the transducer surface. A determination is made whether the actual location of a transducer element differs from the expected location. Drive signals of certain transducer elements having actual locations that differ from expected locations are adjusted to control the output of the transducer.