Patents by Inventor Oleg Pustovyy

Oleg Pustovyy has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11013426
    Abstract: Many factors contribute to dogs' superior olfactory capabilities as compared to humans. Studies explored this aspect at the cellular and behavior levels; however, the cognitive-level neural substrates linking them have never been explored. Since sedated dogs cannot sniff, the present application illustrates the cognitive-level linking neural substrate using fMRI of conscious dogs. The head motion of the canine is accounted for by behavioral training and optical motion tracking. The olfactory bulb is commonly activated in both awake and anesthetized dogs, while parietal and frontal structures are activated only in the former and subcortical structures only in the latter. Comparison of low and high odor intensity shows differences in both the strength and spatial extent of activation in higher cognitive structures. Unlike humans, neural structures even at the top of the cognitive hierarchy are modulated by odor concentration in dogs.
    Type: Grant
    Filed: January 25, 2016
    Date of Patent: May 25, 2021
    Assignee: Auburn University
    Inventors: Gopikrishna Deshpande, Paul Waggoner, Vitaly Vodyanoy, Hao Jia, Oleg Pustovyy, Thomas Denney, Ed Morrison, Ronald Beyers
  • Patent number: 10806754
    Abstract: A pharmaceutical composition comprises a metal nanoparticle having an average diameter of about 0.5 nm to about 5 nm. The composition may be used to treat cancer or an anosmia-related disease.
    Type: Grant
    Filed: March 21, 2018
    Date of Patent: October 20, 2020
    Assignee: Auburn University
    Inventors: Vitaly Vodyanoy, Oleg Pustovyy, Ludmila Globa, Mahmoud Mansour, Iryna Sorokulova
  • Publication number: 20160213279
    Abstract: Many factors contribute to dogs superior olfactory capabilities as compared to humans. Studies explored this aspect at the cellular and behavior levels; however, the cognitive-level neural substrates linking them have never been explored. Since sedated dogs cannot sniff, the present application illustrates the cognitive-level linking neural substrate using fMRI of conscious dogs. The head motion of the canine is accounted for by behavioral training and optical motion tracking. The olfactory bulb is commonly activated in both awake and anesthetized dogs, while parietal and frontal structures are activated only in the former and subcortical structures only in the latter. Comparison of low and high odor intensity shows differences in both the strength and spatial extent of activation in higher cognitive structures. Unlike humans, neural structures even at the top of the cognitive hierarchy are modulated by odor concentration in dogs.
    Type: Application
    Filed: January 25, 2016
    Publication date: July 28, 2016
    Applicant: Auburn University
    Inventors: Gopikrishna Deshpande, Paul Waggoner, Vitaly Vodyanoy, Hao Jia, Oleg Pustovyy, Thomas Denney, Ed Morrison, Ronald Beyers
  • Patent number: 7688505
    Abstract: An annular diaphragm and filter used for the simultaneous observation of darkfield images and fluorescence. The diaphragm has a variable diameter controlled by a lever and a removable filter. The diaphragm is used to adjust the amount of unfiltered incident light which produces darkfield images when directed on a sample. The removable filter is used to filter light to a particular frequency for producing fluorescence images. An Acousto-Optical Tunable Filter, or other such tunable filter may be used with the diaphragm. A method of using the diaphragm and filter is also disclosed.
    Type: Grant
    Filed: December 8, 2006
    Date of Patent: March 30, 2010
    Assignee: Auburn University
    Inventors: Vitaly Vodyanoy, Oleg Pustovyy
  • Patent number: 7551349
    Abstract: The present invention is an improved illumination system which achieves enhanced spatial resolution and contrast in the observation of small objects. The enhanced performance is achieved by using a metal-halide light source, a power conservative pre-condenser optics train, an annular diaphragm, a cardioid annular condenser, and an adjustable light-filtering iris. These features are also intended to be used with a direct-view light optical microscope. A method of manufacturing and using the improved illumination system is also disclosed.
    Type: Grant
    Filed: December 1, 2006
    Date of Patent: June 23, 2009
    Assignee: Auburn University
    Inventors: Vitaly Vodyanoy, Arnold Vainrub, Oleg Pustovyy
  • Publication number: 20070242336
    Abstract: The present invention involves methods to combine light and apparatuses to accomplish the same. In some embodiments of the present invention, light from two light sources is combined to achieve multiple functions within one application. In some embodiments of the present invention, light from the light source is filtered using traditional high-contrast filters, transmission filters or the like. In some embodiments of the present invention, novel low contrast filters and variable contrast filters are used. These filters allow passing a light with a narrow frequency band of large intensity, while the broad spectrum light of smaller intensity is still passing through the filter. In some embodiments of the present invention, a strobing effect is used to combine light.
    Type: Application
    Filed: February 20, 2007
    Publication date: October 18, 2007
    Inventors: Vitaly Vodyanoy, Oleg Pustovyy
  • Publication number: 20070242335
    Abstract: A method and apparatus for filtering and mixing light is provided. The apparatus comprises a translational filter, aperture and shutter. A light beam and the translational filter, aperture and shutter are moved relative to each other to precisely control the proportions of filtered, unobstructed and blocked light. A method for precisely controlling the proportions of filtered, unobstructed and blocked light is also provided. Optional accessories include additional translational filters, apertures and shutters, light guides, relay lenses, microscopes, computers, motors for controlling the positions of the components, focusing lenses, and mechanical shutters.
    Type: Application
    Filed: February 20, 2007
    Publication date: October 18, 2007
    Inventors: Thomas Hasling, Vitaly Vodyanoy, Oleg Pustovyy
  • Publication number: 20070139764
    Abstract: An annular diaphragm and filter used for the simultaneous observation of darkfield images and fluorescence. The diaphragm has a variable diameter controlled by a lever and a removable filter. The diaphragm is used to adjust the amount of unfiltered incident light which produces darkfield images when directed on a sample. The removable filter is used to filter light to a particular frequency for producing fluorescence images. An Acousto-Optical Tunable Filter, or other such tunable filter may be used with the diaphragm. A method of using the diaphragm and filter is also disclosed.
    Type: Application
    Filed: December 8, 2006
    Publication date: June 21, 2007
    Inventors: Vitaly Vodyanoy, Oleg Pustovyy
  • Publication number: 20070128642
    Abstract: Compositions and methods for the isolation and manipulation of misfolded, or partially misfolded, proteins present in blood and other biological materials are provided. In one aspect of the invention, the compositions, hereinafter termed “proteons” are comprised of misfolded proteins. Also provided are compositions and methods for the isolation and manipulation of proteon nucleation centers (PNCs) upon which the proteons of the present in blood and other biological materials form. In another aspect of the invention, the PNCs are comprised of metallic nanoclusters.
    Type: Application
    Filed: November 16, 2006
    Publication date: June 7, 2007
    Inventors: Vitaly Vodyanoy, Alexandre Samoylov, Oleg Pustovyy
  • Publication number: 20070127117
    Abstract: The present invention is an improved illumination system which achieves enhanced spatial resolution and contrast in the observation of small objects. The enhanced performance is achieved by using a metal-halide light source, a power conservative pre-condenser optics train, an annular diaphragm, a cardioid annular condenser, and an adjustable light-filtering iris. These features are also intended to be used with a direct-view light optical microscope. A method of manufacturing and using the improved illumination system is also disclosed.
    Type: Application
    Filed: December 1, 2006
    Publication date: June 7, 2007
    Inventors: Vitaly Vodyanoy, Arnold Vainrub, Oleg Pustovyy
  • Publication number: 20070122799
    Abstract: Compositions and methods for the isolation and manipulation of misfolded, or partially misfolded, proteins present in blood and other biological materials are provided. In one aspect of the invention, the compositions, hereinafter termed “proteons” are misfolded or partially misfolded proteins surrounding a metallic nanocluster, termed “proteon nucleation center” (PNC). Also provided are compositions and methods for the isolation and manipulation of proteon nucleation centers (PNCs) upon which the proteons of the present in blood and other biological materials form.
    Type: Application
    Filed: September 19, 2006
    Publication date: May 31, 2007
    Inventors: Vitaly Vodyanoy, Alexandre Samoylov, Oleg Pustovyy
  • Publication number: 20070014002
    Abstract: The present invention is a dark field illumination system including a light source which is fixed on an entrance slit of a condenser and an objective aligned with the condenser such that the objective and the condenser are adjusted to find a focus spot on a sample. The present invention essentially uses structured illumination to achieve an improved illumination system. The present invention also includes a system and method wherein the objective is coupled to an iris and aligned with the condenser such that when the iris is closed only dark field images are produced, and when the iris is open, direct entrance of light is allowed into the objective and bright field illumination is produced.
    Type: Application
    Filed: July 14, 2006
    Publication date: January 18, 2007
    Inventors: Vitaly Vodyanoy, Oleg Pustovyy, Arnold Vainrub
  • Publication number: 20050237605
    Abstract: An illumination system for a microscope, including a light source for generating light to illuminate a sample for microscopic observation, at least one collimating lens for collimating light generated by the light source, and a darkfield condenser for receiving collimated light and directing a hollow cone of light onto the sample under observation. The system optionally includes an adapter for enhancing economy of light transmission from the light source to the specimen, the adapter having a centrally disposed spacer and a plurality of optical fibers surrounding the spacer, to generate a hollow cylinder of light for transmission to the darkfield condenser. The system provides improved resolution and contrast, and is well suited for adaptation to fluorescence microscopy techniques.
    Type: Application
    Filed: April 15, 2005
    Publication date: October 27, 2005
    Inventors: Vitaly Vodyanoy, Oleg Pustovyy, Thomas Hasling
  • Publication number: 20050142611
    Abstract: Compositions and methods for the isolation and manipulation of misfolded, or partially misfolded, proteins present in blood and other biological materials are provided. In one aspect of the invention, the compositions, hereinafter termed “proteons” are comprised of misfolded proteins. Also provided are compositions and methods for the isolation and manipulation of proteon nucleation centers (PNCs) upon which the proteons of the present in blood and other biological materials form. In another aspect of the invention, the PNCs are comprised of metallic nanoclusters.
    Type: Application
    Filed: December 6, 2004
    Publication date: June 30, 2005
    Applicant: Auburn University
    Inventors: Vitaly Vodyanoy, Alexandre Samoylov, Oleg Pustovyy