Abstract: The disclosure includes methods of treating a patient suffering from a malignant disease driven by activating mutations in KIT, said method comprising: (a) obtaining a biological sample from the patient; (b) detecting the presence or absence of a KIT mutation selected from V654A in exon 13, N655T in exon 13, and T670I in exon 14 in the biological sample; and (c) administering a KIT inhibitor to the patient if the mutation is not detected.

Abstract: A method and a device for cutting up bulky metal parts using a shearing assembly that includes a fixed lower jaw including a first cutting edge and an associated horizontal first bearing surface for the metal part, and an upper jaw that can be swiveled relative to the lower jaw and including a second cutting edge, the cutting edges forming a V-shape at the beginning of the cutting-up process. To facilitate easy positioning of the metal parts between the upper and lower jaws, it is proposed to position the metal part on a support that is composed of a first bearing surface of the lower jaw and a second bearing surface stretching laterally next to the first and in vertical projection under the upper jaw, and that the upper jaw is moved towards the lower jaw while at the same time adjusting the second bearing surface together with the upper jaw.

Abstract: The present invention relates to a novel method for the amplification of DNA, this method being particularly useful for the amplification of the DNA or the whole genome of a single cell, chromosomes or fragments thereof. Described is also the use of the method in DNA analysis for medical, forensic, diagnostic or scientific purposes, like comparative genomic hybridization (CGH)-, fluorescence in situ hybridization (FISH)-, polymerase chain reaction (PCR)-, single strand conformation polymorphism (SSCP)-, DNA sequence-, “loss of heterozygosity” (LOH)-, fingerprint- and/or restriction fragment length polymorphism (RFLP)-analysis.