Abstract: The disclosure includes methods of treating a patient suffering from a malignant disease driven by activating mutations in KIT, said method comprising: (a) obtaining a biological sample from the patient; (b) detecting the presence or absence of a KIT mutation selected from V654A in exon 13, N655T in exon 13, and T670I in exon 14 in the biological sample; and (c) administering a KIT inhibitor to the patient if the mutation is not detected.

Abstract: The present invention relates to a novel method for the amplification of DNA, this method being particularly useful for the amplification of the DNA or the whole genome of a single cell, chromosomes or fragments thereof. Described is also the use of the method in DNA analysis for medical, forensic, diagnostic or scientific purposes, like comparative genomic hybridization (CGH)-, fluorescence in situ hybridization (FISH)-, polymerase chain reaction (PCR)-, single strand conformation polymorphism (SSCP)-, DNA sequence-, “loss of heterozygosity” (LOH)-, fingerprint- and/or restriction fragment length polymorphism (RFLP)-analysis.