Patents by Inventor Olena Deryabina

Olena Deryabina has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for obtaining single chain antibodies to human interferon ?2b
    Patent number: 7435804
    Abstract: A bacterial high-expression system which is applicable for simultaneous screening of large numbers of recombinant clones from combinatorial antibody libraries is disclosed. The method pertains to screening of single chain antibodies from libraries expressed in the periplasm of E. coli by secretion. By this approach, approximately 104 clones can be screened in a single round. After screening, the clones, which express the recombinant antibodies to the desired antigen, can be directly used for production of large quantities of antibodies from microorganism culture. The system is especially attractive for fast screening of antibody libraries from a hybridoma source. A refolding method for the large-scale production of biologically active scFv-6 his proteins from bacterial inclusion bodies is also disclosed.
    Type: Grant
    Filed: October 19, 2004
    Date of Patent: October 14, 2008
    Assignee: Phage Biotechnology, Inc.
    Inventors: Vitaliy A. Kordyum, Oleg Okunev, Pavlo Gilchuk, Olena Deryabina, Dmitro Irodov
  • Method for obtaining single chain antibodies to human interferon alpha2b
    Publication number: 20060105389
    Abstract: A bacterial high-expression system which is applicable for simultaneous screening of large numbers of recombinant clones from combinatorial antibody libraries is disclosed. The method pertains to screening of single chain antibodies from libraries expressed in the periplasm of E. coli by secretion. By this approach, approximately 104 clones can be screened in a single round. After screening, the clones, which express the recombinant antibodies to the desired antigen, can be directly used for production of large quantities of antibodies from microorganism culture. The system is especially attractive for fast screening of antibody libraries from a hybridoma source. A refolding method for the large-scale production of biologically active scFv-6 his proteins from bacterial inclusion bodies is also disclosed.
    Type: Application
    Filed: October 19, 2004
    Publication date: May 18, 2006
    Inventors: Vitaliy Kordyum, Oleg Okunev, Pavlo Gilchuk, Olena Deryabina, Dmitro Irodov