Patents by Inventor Olesya KHARENKO

Olesya KHARENKO has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • COMBINATION THERAPY FOR THE TREATMENT OF ESTROGEN-RECEPTOR POSITIVE BREAST CANCER
    Publication number: 20220047563
    Abstract: Methods for treating estrogen receptor positive (ER+) breast cancer, comprising administering to a subject in need thereof, a BET bromodomain inhibitor in combination with a second agent, selected from a selective-estrogen receptor degrader (SERD), a selective-estrogen receptor modulator (SERM) and a selective CDK4/6 inhibitor. The BET bromodomain inhibitor is selected from 1-benzyl-6-(3,5-dimethylisoxazol-4-yl)-N-methyl-1H-imidazo[4,5-b]pyridin-2-amine (Compound I), 1-benzyl-6-(3,5-dimethylisoxazol-4-yl)-1H-imidazo [4,5-b]pyridin-2-amine, and pharmaceutically acceptable salts/co-crystals thereof.
    Type: Application
    Filed: September 13, 2019
    Publication date: February 17, 2022
    Inventors: Eric CAMPEAU, Olesya KHARENKO, Edward T.H. VAN DER HORST
  • Substituted heterocycles as bromodomain inhibitors
    Patent number: 10292968
    Abstract: The present application relates to substituted heterocycles compound of Formula I and pharmaceutical compositions thereof useful for the inhibition of BET protein function by binding to bromodomains (Formula I).
    Type: Grant
    Filed: December 11, 2015
    Date of Patent: May 21, 2019
    Assignee: Zenith Epigenetics Ltd.
    Inventors: Samuel David Brown, Craig Alan Coburn, Olesya Kharenko
  • Inhibitors of bromodomains
    Patent number: 10231953
    Abstract: The present disclosure relates to compounds capable of acting as covalent inhibitors of bromodomains and the therapeutic use of these inhibitors.
    Type: Grant
    Filed: December 16, 2015
    Date of Patent: March 19, 2019
    Assignee: Zenith Epigenetics Ltd.
    Inventors: Olesya Kharenko, Peter Ronald Young, Samuel David Brown, Bryan Cordell Duffy, Shuang Liu, Peter Guzzo
  • Inhibitors of Bromodomains
    Publication number: 20170360760
    Abstract: The present disclosure relates to compounds capable of acting as covalent inhibitors of bromodomains and the therapeutic use of these inhibitors.
    Type: Application
    Filed: December 16, 2015
    Publication date: December 21, 2017
    Inventors: Olesya KHARENKO, Peter Ronald YOUNG, Samuel David BROWN, Bryan Cordell DUFFY, Shuang LIU, Peter GUZZO