Abstract: One variation of a method for refinancing arbitrage structured product investments comprising: receiving selection of a tranche—associated with an initial interest margin and containing an outstanding debt quantity—within a structured product investment by an initiator; assigning a target interest margin, less than the initial interest margin, to the tranche; initiating an online public auction for the outstanding debt quantity; during the online public auction, recording a set of bids submitted by a set of investors, each bid in the set specifying a debt quantity at the target interest margin; calculating a sum of debt quantities, at the target interest margin, specified in the set of bids; and, in response to the sum of debt quantities clearing the outstanding debt quantity upon conclusion of the online public auction, initiating settlement and redistribution of the outstanding debt quantity in the tranche according to the set of bids.

Abstract: One variation of a method for refinancing arbitrage structured product investments comprising: receiving selection of a tranche—associated with an initial interest margin and containing an outstanding debt quantity—within a structured product investment by an initiator; assigning a target interest margin, less than the initial interest margin, to the tranche; initiating an online public auction for the outstanding debt quantity; during the online public auction, recording a set of bids submitted by a set of investors, each bid in the set specifying a debt quantity at the target interest margin; calculating a sum of debt quantities, at the target interest margin, specified in the set of bids; and, in response to the sum of debt quantities clearing the outstanding debt quantity upon conclusion of the online public auction, initiating settlement and redistribution of the outstanding debt quantity in the tranche according to the set of bids.

Abstract: A method for hosting a multi-stage, token-gated electronic auction includes: during a blind-bidding period, receiving a set of blind bids from bidders on an electronic biding platform and obfuscating blind bid information of other bid from bidders for each blind bidder; after the blind-bidding period, selecting a subset of bidders equal to a live-bidder quantity and associated with blind bids of greatest value, generating a set of digital access tokens for live-bidding, and assigning the digital access tokens to the subset of bidders; and, during a subsequent live-bidding period, admitting the subset of bidders into a virtual private live-bidding room based on the digital access tokens, receiving live bids from the subset of bidders, publishing bid values of live bids received from other bidder for each live bidder, and obfuscating live bid information for bidders other than the subset of bidders.

Abstract: In various aspects and embodiments provided are methods for treating age-related diseases or disorders and/or treating or preventing frailty in a patient. In certain embodiments the methods include administering a recombinant TLR5 agonist (e.g., a flagellin-based agent).

Abstract: One variation of a method for initiating and hosting an auction for a security includes: accessing historical trade data and characteristics of a corpus of securities traded on an auction platform; assigning post-auction liquidity scores to the corpus of securities based on historical trading result data; constructing a liquidity model representing correlations between characteristics and pre-auction liquidity scores of the corpus of securities; accessing characteristics of a security held by a seller; calculating a liquidity score of the security based on characteristics of the security and the liquidity model; assigning a rule profile—defining rules for distribution of feedback to bidders during an auction—to the security based on the liquidity score of the security; initiating an auction for the security on the auction platform; and, during the auction, distributing feedback for bids according to the rule profile.

Abstract: One variation of a method for initiating and hosting an auction for a security includes: accessing historical trade data and characteristics of a corpus of securities traded on an auction platform; assigning post-auction liquidity scores to the corpus of securities based on historical trading result data; constructing a liquidity model representing correlations between characteristics and pre-auction liquidity scores of the corpus of securities; accessing characteristics of a security held by a seller; calculating a liquidity score of the security based on characteristics of the security and the liquidity model; assigning a rule profile—defining rules for distribution of feedback to bidders during an auction—to the security based on the liquidity score of the security; initiating an auction for the security on the auction platform; and, during the auction, distributing feedback for bids according to the rule profile.

Abstract: One variation of a method for refinancing arbitrage structured product investments comprising: receiving selection of a tranche—associated with an initial interest margin and containing an outstanding debt quantity—within a structured product investment by an initiator; assigning a target interest margin, less than the initial interest margin, to the tranche; initiating an online public auction for the outstanding debt quantity; during the online public auction, recording a set of bids submitted by a set of investors, each bid in the set specifying a debt quantity at the target interest margin; calculating a sum of debt quantities, at the target interest margin, specified in the set of bids; and, in response to the sum of debt quantities clearing the outstanding debt quantity upon conclusion of the online public auction, initiating settlement and redistribution of the outstanding debt quantity in the tranche according to the set of bids.

Abstract: In various aspects and embodiments provided are compounds, compositions and methods relating to aging, senescent cells (SCs) and/or senescence associate macrophages (SAMs). In certain aspects and embodiments provided are compounds and compositions that selectively kill or reprogram senescent cells (SCs) and or senescence associate macrophages (SAMs) and associated methods. In some embodiments, the compounds compositions and methods treat or reverse aging organism Normal tissue and/or age-related diseases.

Abstract: Benzamide and nicotinamide compounds and uses of the compounds. The compounds can be used to treat, for example, cancers such hematopoietic cancers (e.g., leukemia).

Abstract: The present disclosure provides benzamide and nicotinamide compounds and pharmaceutical uses of the compounds. The compounds can be used to treat, for example, cancers such hematopoietic cancers (e.g., leukemia). The preferred compounds of the invention contain a phenylethynyl moiety as well as an amine-based heterocyclyl or heteroaryl moiety attached to the benzamide or nicotinamide compound.

Abstract: Benzamide and nicotinamide compounds and uses of the compounds. The compounds can be used to treat, for example, cancers such hematopoietic cancers (e.g., leukemia).

Abstract: Compositions and methods for selective partial or complete eradication of senescent cells in a mammal are provided. The involves inhibition of the expression of genes that are identified as being related to a senescent phenotype. The inhibition is produced using methods which include but are not necessarily limited to pharmacological inhibition, or inhibition by using RNAi-mediated approaches. As a consequence of selectively targeting senescent cells, prolonging or restoring healthy physiological conditions in a mammal can be achieved, and age related conditions can be treated or prevented, and undesirable accumulated senescent cells can be reduced or eradicated from a variety of tissues.

Abstract: The present disclosure provides benzamide and nicotinamide compounds and pharmaceutical uses of the compounds. The compounds can be used to treat, for example, cancers such hematopoietic cancers (e.g., leukemia). The preferred compounds of the invention contain a phenylethynyl moiety as well as an amine-based heterocyclyl or heteroaryl moiety attached to the benzamide or nicotinamide compound.

Abstract: Compositions and methods for selective partial or complete eradication of senescent cells in a mammal are provided. The involves inhibition of the expression of genes that are identified as being related to a senescent phenotype. The inhibition is produced using methods which include but are not necessarily limited to pharmacological inhibition, or inhibition by using RNAi-mediated approaches. As a consequence of selectively targeting senescent cells, prolonging or restoring healthy physiological conditions in a mammal can be achieved, and age related conditions can be treated or prevented, and undesirable accumulated senescent cells can be reduced or eradicated from a variety of tissues.

Abstract: Provided are compositions and methods for aiding in healing of a tissue wound in an individual. The method generally entail delivering to an individual in need thereof senescent cells such that healing of the wound is accelerated. The disclosure includes use of senescent cells and senescent tumor cells, either of which may be allogeneic or autologous to the individual. Also provided are methods for inducing senescence in cells and using the cells for wound healing, and articles of manufacture comprising senescent cells for use in wound healing.