Patents by Inventor Olga Ignatovich

Olga Ignatovich has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • COMPOSITIONS MONOVALENT FOR CD28 BINDING AND METHODS OF USE
    Publication number: 20100028354
    Abstract: Disclosed are domain antibodies that monovalently bind CD28. Domain antibodies that are monovalent for binding of CD28 can inhibit CD28 activity. In one aspect, a domain antibody consists of or comprises a single immunoglobulin variable domain that specifically binds and antagonizes the activity of CD28, in an aspect, without substantially agonizing CD28 activity. In another aspect, the domain antibody is a human domain antibody. The disclosure further encompasses methods of antagonizing CD80 and/or CD86 interactions with CD28 in an individual and methods of treating diseases or disorders involving CD80 and/or CD86 interactions with CD28, the methods involving administering a domain antibody to the individual.
    Type: Application
    Filed: July 17, 2009
    Publication date: February 4, 2010
    Applicants: Bristol-Myers Squibb Company, Domantis Ltd.
    Inventors: Murray McKinnon, Steven G. Nadler, Suzanne J. Suchard, Brendan Classon, Steve Holmes, Olga Ignatovich, Christopher Plummer, Steve Grant
  • COMPOSITIONS AND METHODS FOR TREATING INFLAMMATORY DISORDERS
    Publication number: 20090258012
    Abstract: The invention relates to compositions and methods for treating inflammatory disorders. More specifically, the invention relates to antibody compositions and their use in the treatment of inflammatory disorders.
    Type: Application
    Filed: March 24, 2009
    Publication date: October 15, 2009
    Applicant: Domantis Limited
    Inventors: Olga Ignatovich, Rudolf Maria Theodora de Wildt, Benjamin Woolven, Steven Grant, Philip C. Jones, Amrik Basran, Neil Brewis
  • Ligands that have binding specificity for VEGF and/or EGFR and methods of use therefor
    Publication number: 20090081233
    Abstract: Disclosed are ligands that have binding specificity for vascular endothelial growth factor (VEGF), for epidermal growth factor receptor (EGFR), or for VEGF and EGFR. Also disclosed are methods of using these ligands. In particular, the use of these ligands for cancer therapy is described.
    Type: Application
    Filed: July 9, 2008
    Publication date: March 26, 2009
    Applicant: Domantis Limited
    Inventors: Olga Ignatovich, Steve Holmes, Roland Beckmann, Rudolf M.T. de Wildt, Armin Sepp
  • Ligands that bind a receptor
    Publication number: 20080241166
    Abstract: The invention relates to ligands, such as immunoglobulin single variable domains, that have binding specificity for a receptor. Preferably the receptor is a cell surface receptor and/or the ligand inhibits the activity of the receptor.
    Type: Application
    Filed: January 7, 2008
    Publication date: October 2, 2008
    Applicant: Domantis Limited
    Inventors: Ian M. Tomlinson, Gregory P. Winter, Olga Ignatovich, Philip C. Jones, Lucy J. Holt
  • Ligands that have binding specificity for VEGF and/or EGFR and methods of use therefor
    Publication number: 20070003549
    Abstract: Disclosed are ligands that have binding specificity for vascular endothelial growth factor (VEGF), for epidermal growth factor receptor (EGFR), or for VEGF and EGFR. Also disclosed are methods of using these ligands. In particular, the use of these ligands for cancer therapy is described.
    Type: Application
    Filed: January 11, 2006
    Publication date: January 4, 2007
    Inventors: Olga Ignatovich, Steve Holmes, Roland Beckmann, Rudolf de Wildt
  • Retargeting
    Publication number: 20060280734
    Abstract: The present invention relates to a method for the generation of immunoglobulin molecules of predetermined specificity. In particular, the invention relates to a method for the retargeting of the epitope binding specificity of one or more antibodies using single variable domains which exhibit a dominant epitope binding specificity.
    Type: Application
    Filed: June 24, 2005
    Publication date: December 14, 2006
    Inventors: Gregory Winter, Ian Tomlinson, Olga Ignatovich
  • Ligand
    Publication number: 20060257406
    Abstract: The invention provides a dual-specific ligand comprising a first immunoglobulin variable domain having a first binding specificity for a target ligand and a complementary or non-complementary immunoglobulin variable domain having a second binding specificity for a receptor of the target ligand.
    Type: Application
    Filed: May 31, 2005
    Publication date: November 16, 2006
    Inventors: Greg Winter, Ian Tomlinson, Olga Ignatovich, Ben Woolven, Philip Jones
  • Ligand
    Publication number: 20060106203
    Abstract: The invention provides a dual-specific ligand comprising a first immunoglobulin variable domain having a first binding specificity and a complementary or non-complementary immunoglobulin variable domain having a second binding specificity.
    Type: Application
    Filed: December 28, 2004
    Publication date: May 18, 2006
    Inventors: Greg Winter, Ian Tomlinson, Olga Ignatovich, Lucy Holt, Elena De Angelis, Philip Jones
  • Fc fusion
    Publication number: 20060083747
    Abstract: The present invention relates to a simple method for generating antibody-based structures suitable for in vivo use. In particular, the invention relates to a method for the generation of antibody-based structures suitable for in vivo use comprising the steps of: (a) selecting an antibody single variable domain having an epitope binding specificity; and (b) attaching the single domain of step (a) to an effector group. Uses of molecules generated using the method of the Invention are also described.
    Type: Application
    Filed: June 24, 2005
    Publication date: April 20, 2006
    Inventors: Gregory Winter, Ian Tomlinson, Olga Ignatovich, Neil Brewis
  • Compositions and methods for treating inflammatory disorders
    Publication number: 20060073141
    Abstract: The invention relates to compositions and methods for treating inflammatory disorders. More specifically, the invention relates to antibody compositions and their use in the treatment of inflammatory disorders.
    Type: Application
    Filed: April 4, 2005
    Publication date: April 6, 2006
    Inventors: Olga Ignatovich, Rudolf de Wildt, Benjamin Woolven, Steven Grant, Philip Jones, Amrik Basran, Neil Brewis
  • Compositions and methods for treating inflammatory disorders
    Publication number: 20050271663
    Abstract: The invention relates to compositions and methods for treating inflammatory disorders. More specifically, the invention relates to antibody compositions and their use in the treatment of inflammatory disorders.
    Type: Application
    Filed: August 24, 2004
    Publication date: December 8, 2005
    Inventors: Olga Ignatovich, Rudolf de Wildt, Benjamin Woolven, Steven Grant, Philip Jones, Amrik Basran, Neil Brewis
  • Dual-specific ligand
    Publication number: 20040219643
    Abstract: The invention provides dual-specific ligand comprising a first single immunoglobulin variable domain having a first binding specificity and a complementary immunoglobulin single variable domain having a second binding specificity.
    Type: Application
    Filed: December 23, 2003
    Publication date: November 4, 2004
    Inventors: Greg Winter, Olga Ignatovich, Ian Tomlinson, Philip C. Jones