Patents by Inventor Olga Khersonsky

Olga Khersonsky has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • ENZYME VARIANTS
    Publication number: 20240043820
    Abstract: Provided herein are Cas9 proteins comprising SEQ ID NO:1 or a sequence at least 80% identical thereto, wherein: the amino acid residues at positions 765 to 780 are replaced by the amino acid sequence of SEQ ID NO:5 or SEQ ID NO:6; the amino acid residues at positions 838 to 853 are replaced by the amino acid sequence of SEQ ID NO:7, SEQ ID NO:8, SEQ ID NO:9 or SEQ ID NO:10; and/or the amino acid residues at positions 911 to 925 are replaced by the amino acid sequence of SEQ ID NO:11, SEQ ID NO:12 or SEQ ID NO:13.
    Type: Application
    Filed: December 13, 2021
    Publication date: February 8, 2024
    Inventors: Oliver Rackham, Aleksandra Filipovska, Pascal Vos, Sarel-Jacob Fleishman, Olga Khersonsky
  • VARIANTS OF BETA-GLUCOCEREBROSIDASE FOR USE IN TREATING GAUCHER DISEASE
    Publication number: 20230132790
    Abstract: A genetically modified human beta-glucocerebrosidase (GCase) is disclosed. The genetically modified GCase comprising an amino acid sequence at least 85% identical to SEQ ID NO: 2; and comprising mutations at coordinates L34P, K224N/G, T369E and N370D, where the coordinates correspond to said SEQ ID NO: 2; and capable of catalyzing hydrolysis of a glycolipid glucosylceramide (GlcCer). Pharmaceutical compositions comprising the genetically modified GCase and therapeutic methods of using same are also disclosed.
    Type: Application
    Filed: March 29, 2021
    Publication date: May 4, 2023
    Applicant: Yeda Research and Development Co. Ltd.
    Inventors: Anthony H. FUTERMAN, Israel SILMAN, Joel L. SUSSMAN, Sarel FLEISHMAN, Adi GOLDENZWEIG, Sarka POKORNA, Yaacov ASHANI, Olga KHERSONSKY
  • Pyocyanine Demethylases and related Phenazine Degrading Agents Compositions, Methods and Systems for Interfering with Viability of Bacteria
    Publication number: 20220175892
    Abstract: Provided herein are engineered pyocyanine demethylases having replacements in in positions A53, I73, A87, T91, M99, A129 and K141 of pyocyanine demethylase PodA of SEQ ID NO: 1 or a derivative thereof and related phenazine degrading agents, compositions methods and systems, as well as a combined administration of one or more pyocyanine demethylases and antibiotics and/or antibiotics resulting in a synergic inhibition of viability of phenazine producing bacteria, and related phenazine degrading agents, compositions methods and systems.
    Type: Application
    Filed: November 5, 2021
    Publication date: June 9, 2022
    Inventors: Dianne K Newman, Chelsey M VanDrisse, Rosalie Lipsh-Sokolik, Olga Khersonsky, Sarel J Fleishman
  • DESIGNED, EFFICIENT AND BROAD-SPECIFICITY ORGANOPHOSPHATE HYDROLASES
    Publication number: 20210178207
    Abstract: Provided herein is a library of designed phosphotriesterase (PTE) enzymes, exhibiting an improved catalytic hydrolysis activity of various substrates, including nerve agents, and a general method of generating and using the same.
    Type: Application
    Filed: August 14, 2019
    Publication date: June 17, 2021
    Applicant: Yeda Research and Development Co. Ltd.
    Inventors: Sarel FLEISHMAN, Dan S. TAWFIK, Olga KHERSONSKY
  • METHODS OF DETERMINING TOTAL PON1 LEVEL
    Publication number: 20100099118
    Abstract: A method of determining an amount of total PON1 in a sample of a subject is disclosed. The method comprises: (a) contacting the sample with a compound being capable of generating at least one spectrophotometrically detectable moiety upon contact with PON1, under conditions wherein the generating is not dependent on a PON1 status; and (b) spectrophotometrically measuring a level of the moiety, thereby determining an amount of total PON1 in the sample. Kits for measuring total PON1 levels comprising the compounds are also disclosed.
    Type: Application
    Filed: March 11, 2008
    Publication date: April 22, 2010
    Applicant: Yeda Research And Development Co., Ltd.
    Inventors: Leonid Gaydukov, Olga Khersonsky, Dan S. Tawfik
  • Method Of Diagnosing Pon1-Hdl Associated Lipid Disorders
    Publication number: 20100028924
    Abstract: Methods and kits for diagnosing a lipid-related disorder are disclosed. Methods and pharmaceutical compositions for treating lipid-related disorders are also disclosed.
    Type: Application
    Filed: March 18, 2007
    Publication date: February 4, 2010
    Applicant: Rappaport Family Institute Research in the Medical Sciences
    Inventors: Leonid Gaydukov, Olga Khersonsky, Dan S. Tawfik, Michael Aviram
  • Methods and compositions for determing a level of biologically active serum paraoxonase
    Publication number: 20090305239
    Abstract: A method of determining a level of biologically active PON enzyme is provided. The method comprising determining lactonase activity of the PON enzyme, the lactonase activity being indicative of the level of biologically active PON enzyme. Also provided are novel compounds which may be used for measuring a lactonase activity of an enzyme.
    Type: Application
    Filed: August 14, 2006
    Publication date: December 10, 2009
    Inventors: Dan S. Tawfik, Olga Khersonsky