Abstract: The subject invention is directed to devices and methods for producing devices for regulating blood flow in the venous system. In particular, the invention provides for artificial valves designed to regulate the flow of blood in human vessels, wherein such artificial valves include superior properties including fatigue resistance, biocompatibility, and ease of manufacture.

Abstract: The subject invention is directed to devices and methods for producing devices for regulating blood flow in the venous system. In particular, the invention provides for artificial valves designed to regulate the flow of blood in human vessels, wherein such artificial valves include superior properties including fatigue resistance, biocompatibility, and ease of manufacture.

Abstract: The subject invention is directed to devices and methods for producing devices for regulating blood flow in the venous system. In particular, the invention provides for artificial valves designed to regulate the flow of blood in human vessels, wherein such artificial valves include superior properties including fatigue resistance, biocompatibility, and ease of manufacture.

Abstract: The artificial valves and methods described herein and shown in the drawings, provide for artificial valves with superior properties including fatigue resistance, biocompatibility, and ease of manufacture.

Abstract: A vascular graft comprising a traditional graft material and an electrospun fibrous layer. The solvent used to reduce the material for the electrospun layer is also capable of reducing the graft material to a liquid solution. The electrospun layer is chemically bonded to the graft material, without adhesives, by either spraying the graft with the solvent prior to electrospinning or by assuring that a sufficient amount of residual solvent reaches the graft while electrospinning.

Abstract: An intra-aortic balloon catheter having an ultra-thin stretch blow molded balloon membrane. The balloon membrane is made from thermoplastic elastomeric and/or semicrystalline materials such as but not limited to polyurethane and polyetheramid.

Abstract: An intra-aortic balloon catheter having a gas lumen insert disposed within its gas lumen during insertion of the catheter into the blood vessel of a patient. The gas lumen insert facilitates insertion and helps prevent kinking of the catheter.

Abstract: An intra-aortic balloon catheter having an ultra-thin stretch blow molded balloon membrane. The balloon membrane is made from thermoplastic elastomeric and/or semicrystalline materials such as but not limited to polyurethane and polyetheramid.

Abstract: An intra-aortic balloon catheter having an ultra-thin stretch blow molded balloon membrane. The balloon membrane is made from thermoplastic elastomeric and/or semicrystalline materials such as but not limited to polyurethane and polyetheramid.

Abstract: An improved intra-aortic balloon catheter with a balloon membrane, a tip, and a co-lumen extruded tube having an outer lumen and an inner lumen between the inner and outer surfaces of the co-lumen extruded tube. The portion of the co-lumen extruded tube that defines the inner lumen and which is disposed within the balloon membrane is made from polyimide, a lubricous material, to facilitate guide wire tracking. The polyimide inner tube portion demonstrates good kink resistance and flexural stiffness. In a first alternative embodiment of the invention the co-lumen tube comprises an outer tube with an inner tube embedded in the wall of said outer tube. In a second alternative embodiment of the invention a longitudinal signal pathway is provided.

Abstract: The present invention is directed to a fiber optic sensor for analyzing pH which comprises (a) a fluorescence-based fiber optic sensor; and (b) a fluorescent dye-polymeric matrix in contact with the sensor, wherein the fluorescent dye is seminaphthorhodaflor-1-isothiocyanate, the polymer is a hydrogel selected from the group consisting of polyhydroxyethylmethacrylate, polyvinylpyrrolidone, cellulose, dextrans, and polysaccharides, and the dye is chemically bonded to the polymer.