Patents by Inventor Olga Lapina

Olga Lapina has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Crystalline forms of an antiviral compound
    Patent number: 9862728
    Abstract: Crystalline forms of the anti-HCV compound (1aR,5S,8S,9S,10R,22aR)-5-tert-butyl-N-[(1R,2R)-2-(difluoromethyl)-1-{[(1-methylcyclopropyl)sulfonyl]carbamoyl}cyclopropyl]-9-ethyl-18,18-difluoro-14-methoxy-3,6-dioxo-1,1a,3,4,5,6,9,10,18,19,20,21,22,22a-tetradecahydro-8H-7,10-methanocyclopropa[18,19][1,10,3,6]dioxadiazacyclononadecino[11,12-b]quinoxaline-8-carboxamide (Compound I) were prepared and characterized in the solid state: Also provided are processes of manufacture and methods of using the crystalline forms.
    Type: Grant
    Filed: December 21, 2016
    Date of Patent: January 9, 2018
    Assignee: GILEAD SCIENCES, INC.
    Inventors: Dustin Bringley, Johann Chan, Peter Fung, Katie Keaton, Olga Lapina, Henry Morrison, Dominika Pcion
  • CRYSTALLINE FORMS OF AN ANTIVIRAL COMPOUND
    Publication number: 20170267694
    Abstract: Crystalline forms of the anti-HCV compound (1aR,5S,8S,9S,10R,22aR)-5-tert-butyl-N-[(1R,2R)-2-(difluoromethyl)-1-{[(1-methylcyclopropyl)sulfonyl]carbamoyl}cyclopropyl]-9-ethyl-18,18-difluoro-14-methoxy-3,6-dioxo-1,1a,3,4,5,6,9,10,18,19,20,21,22,22a-tetradecahydro-8H-7,10-methanocyclopropa[18,19][1,10,3,6]dioxadiazacyclononadecino[11,12-b]quinoxaline-8-carboxamide (Compound I) were prepared and characterized in the solid state: Also provided are processes of manufacture and methods of using the crystalline forms.
    Type: Application
    Filed: December 21, 2016
    Publication date: September 21, 2017
    Inventors: Dustin Bringley, Johann Chan, Peter Fung, Katie Keaton, Olga Lapina, Henry Morrison, Dominika Pcion
  • Crystalline forms of an antiviral compound
    Patent number: 9562058
    Abstract: Crystalline forms of the anti-HCV compound (1aR,5S,8S,9S,10R,22aR)-5-tert-butyl-N-[(1R,2R)-2-(difluoromethyl)-1-{[(1-methylcyclopropyl)sulfonyl]carbamoyl}cyclopropyl]-9-ethyl-18,18-difluoro-14-methoxy-3,6-dioxo-1,1a,3,4,5,6,9,10,18,19,20,21,22,22a-tetradecahydro-8H-7,10-methanocyclopropa[18,19][1,10,3,6]dioxadiazacyclononadecino[11,12-b]quinoxaline-8-carboxamide (Compound I) were prepared and characterized in the solid state: Also provided are processes of manufacture and methods of using the crystalline forms.
    Type: Grant
    Filed: December 18, 2014
    Date of Patent: February 7, 2017
    Assignee: GILEAD SCIENCES, INC.
    Inventors: Dustin Bringley, Johann Chan, Peter Fung, Katie Keaton, Olga Lapina, Henry Morrison, Dominika Pcion
  • Synthesis of a neurostimulative piperazine
    Patent number: 9481649
    Abstract: The invention describes an improved synthesis for piperazine derivatized with nicotinic acid and a benzyl moiety. The product compounds are useful for treatment of neurological conditions.
    Type: Grant
    Filed: December 9, 2015
    Date of Patent: November 1, 2016
    Assignee: NEURALSTEM, INC.
    Inventors: Sripathy Venkatraman, Syed Mahmood, Bingidimi I. Mobele, Olga Lapina, Kellie Vercoe, Ying Li, Jonathan Salsbury, Mark McLaws
  • SYNTHESIS OF A NEUROSTIMULATIVE PIPERAZINE
    Publication number: 20160090358
    Abstract: The invention describes an improved synthesis for piperazine derivatized with nicotinic acid and a benzyl moiety. The product compounds are useful for treatment of neurological conditions.
    Type: Application
    Filed: December 9, 2015
    Publication date: March 31, 2016
    Applicant: NEURALSTEM, INC.
    Inventors: Sripathy VENKATRAMAN, Syed MAHMOOD, Bingidimi I. MOBELE, Olga LAPINA, Kellie VERCOE, Ying LI, Jonathan SALSBURY, Mark MCLAWS
  • Synthesis of a neurostimulative piperazine
    Patent number: 9278933
    Abstract: The invention describes an improved synthesis for piperazine derivatized with nicotinic acid and a benzyl moiety. The product compounds are useful for treatment of neurological conditions.
    Type: Grant
    Filed: August 24, 2010
    Date of Patent: March 8, 2016
    Assignee: NEURALSTEM, INC.
    Inventors: Sripathy Venkatraman, Syed Mahmood, Bingidimi I. Mobele, Olga Lapina, Kellie Vercoe, Ying Li, Jonathan Salsbury, Mark McLaws
  • CRYSTALLINE FORMS OF AN ANTIVIRAL COMPOUND
    Publication number: 20150175625
    Abstract: Crystalline forms of the anti-HCV compound (1aR,5S,8S,9S,10R,22aR)-5-tert-butyl-N-[(1R,2R)-2-(difluoromethyl)-1-{[(1-methylcyclopropyl)sulfonyl]carbamoyl}cyclopropyl]-9-ethyl-18,18-difluoro-14-methoxy-3,6-dioxo-1,1a,3,4,5,6,9,10,18,19,20,21,22,22a-tetradecahydro-8H-7,10-methanocyclopropa[18,19][1,10,3,6]dioxadiazacyclononadecino[11,12-b]quinoxaline-8-carboxamide (Compound I) were prepared and characterized in the solid state: Also provided are processes of manufacture and methods of using the crystalline forms.
    Type: Application
    Filed: December 18, 2014
    Publication date: June 25, 2015
    Applicant: GILEAD SCIENCES, INC.
    Inventors: Dustin Bringley, Johann Chan, Peter Fung, Katie Keaton, Olga Lapina, Henry Morrison, Dominika Pcion
  • SYNTHESIS OF A NEUROSTIMULATIVE PIPERAZINE
    Publication number: 20130005974
    Abstract: The invention describes an improved synthesis for piperazine derivatized with nicotinic acid and a benzyl moiety. The product compounds are useful for treatment of neurological conditions.
    Type: Application
    Filed: August 24, 2010
    Publication date: January 3, 2013
    Applicant: NEURALSTEM, INC.
    Inventors: Sripathy Venkatraman, Syed Mahmood, Bingidimi I. Mobele, Olga Lapina, Kellie Vercoe, Ying Li, Jonathan Salsbury, Mark McLaws