Patents by Inventor Olga Lomovskaya

Olga Lomovskaya has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • CEFTIBUTEN DOSING REGIMENS
    Publication number: 20240197750
    Abstract: Disclosed herein are dosing regimens of ceftibuten in combination with a ?-lactamase inhibitor. The dosing regimens include ceftibuten at a dose higher than 400 mg per day (for example, 400 mg BID, 600 mg QD or BID, or 800 mg QD or BID).
    Type: Application
    Filed: March 31, 2022
    Publication date: June 20, 2024
    Inventors: David C. Griffith, Olga Lomovskaya, Elizabeth E. Morgan, Jeffery S. Loutit
  • Therapeutic uses of pharmaceutical compositions comprising cyclic boronic acid ester derivatives
    Patent number: 11684629
    Abstract: Disclosed herein are antimicrobial compounds compositions, pharmaceutical compositions, the use and preparation thereof. Some embodiments relate to cyclic boronic acid ester derivatives and their use as therapeutic agents.
    Type: Grant
    Filed: July 16, 2021
    Date of Patent: June 27, 2023
    Assignee: MELINTA SUBSIDIARY CORP.
    Inventors: Gavin Hirst, Raja Reddy, Scott J. Hecker, Maxim Totrov, David C. Griffith, Olga Lomovskaya, Michael N. Dudley, Serge Henri Boyer
  • BORONIC ACID DERIVATIVES AND THERAPEUTIC USES THEREOF
    Publication number: 20230144152
    Abstract: Disclosed herein are antimicrobial compounds compositions, pharmaceutical compositions, the method of use and preparation thereof. Some embodiments relate to boronic acid derivatives and their use as therapeutic agents, for example, ?-lactamase inhibitors (BLIs).
    Type: Application
    Filed: June 17, 2020
    Publication date: May 11, 2023
    Inventor: Olga Lomovskaya
  • THERAPEUTIC USES OF PHARMACEUTICAL COMPOSITIONS COMPRISING CYCLIC BORONIC ACID ESTER DERIVATIVES
    Publication number: 20220125813
    Abstract: Disclosed herein are antimicrobial compounds compositions, pharmaceutical compositions, the use and preparation thereof. Some embodiments relate to cyclic boronic acid ester derivatives and their use as therapeutic agents.
    Type: Application
    Filed: July 16, 2021
    Publication date: April 28, 2022
    Inventors: Gavin HIRST, Raja REDDY, Scott J. HECKER, Maxim TOTROV, David C. GRIFFITH, Olga LOMOVSKAYA, Michael N. DUDLEY, Serge Henri BOYER
  • Therapeutic uses of pharmaceutical compositions comprising cyclic boronic acid ester derivatives
    Patent number: 11090319
    Abstract: Disclosed herein are antimicrobial compounds compositions, pharmaceutical compositions, the use and preparation thereof. Some embodiments relate to cyclic boronic acid ester derivatives and their use as therapeutic agents.
    Type: Grant
    Filed: March 24, 2020
    Date of Patent: August 17, 2021
    Assignee: MELINTA SUBSIDIARY CORP.
    Inventors: Gavin Hirst, Raja Reddy, Scott J. Hecker, Maxim Totrov, David C. Griffith, Olga Lomovskaya, Michael N. Dudley, Serge Henri Boyer
  • USE OF AEROSOLIZED LEVOFLOXACIN FOR TREATING CYSTIC FIBROSIS
    Publication number: 20210228589
    Abstract: Methods for treating cystic fibrosis. The method includes administering to a human in need thereof an aerosol solution comprising levofloxacin or ofloxacin and a divalent or trivalent cation. More particularly, the method includes administering the aerosol solution to a human having a pulmonary infection comprising P. aeruginosa.
    Type: Application
    Filed: August 28, 2020
    Publication date: July 29, 2021
    Inventors: Jeffery S. LOUTIT, Elizabeth E. MORGAN, Michael N. DUDLEY, David C. GRIFFITH, Olga LOMOVSKAYA
  • Cyclic boronic acid ester derivatives and therapeutic uses thereof
    Patent number: 11007206
    Abstract: Method of treating or ameliorating a bacterial infection comprising administering a composition comprising a cyclic boronic acid ester compound in combination with a carbapenem antibacterial agent such as Biapenem, and the pharmacokinetics studies thereof are provided.
    Type: Grant
    Filed: January 17, 2020
    Date of Patent: May 18, 2021
    Assignee: MELINTA SUBSIDIARY CORP.
    Inventors: David C. Griffith, Michael N. Dudley, Olga Lomovskaya
  • Use of aerosolized levofloxacin for treating cystic fibrosis
    Patent number: 10792289
    Abstract: Methods for treating cystic fibrosis. The method includes administering to a human in need thereof an aerosol solution comprising levofloxacin or ofloxacin and a divalent or trivalent cation. More particularly, the method includes administering the aerosol solution to a human having a pulmonary infection comprising P. aeruginosa.
    Type: Grant
    Filed: January 31, 2019
    Date of Patent: October 6, 2020
    Assignee: Horizon Orphan LLC
    Inventors: Jeffery S. Loutit, Elizabeth E. Morgan, Michael N. Dudley, David C. Griffith, Olga Lomovskaya
  • USE OF AEROSOLIZED LEVOFLOXACIN FOR TREATING CYSTIC FIBROSIS
    Publication number: 20200000817
    Abstract: Methods for treating cystic fibrosis. The method includes administering to a human in need thereof an aerosol solution comprising levofloxacin or ofloxacin and a divalent or trivalent cation. More particularly, the method includes administering the aerosol solution to a human having a pulmonary infection comprising P. aeruginosa.
    Type: Application
    Filed: January 31, 2019
    Publication date: January 2, 2020
    Inventors: Jeffery S. LOUTIT, Elizabeth E. MORGAN, Michael N. DUDLEY, David C. GRIFFITH, Olga LOMOVSKAYA
  • METHODS OF TREATING BACTERIAL INFECTIONS
    Publication number: 20190336475
    Abstract: Methods of treating or ameliorating urinary tract infection (UTI), including complicated urinary tract infection (cUTI) and acute pyelonephritis (AP), comprising administering a composition comprising a cyclic boronic acid ester vaborbactam in combination with meropenem are disclosed herewith.
    Type: Application
    Filed: January 8, 2018
    Publication date: November 7, 2019
    Inventors: Jeffrey S. LOUTIT, Michael N. DUDLEY, Elizabeth E. MORGAN, Karen FUSARO, David C. GRIFFITH, Olga LOMOVSKAYA
  • METHODS OF TREATING BACTERIAL INFECTIONS
    Publication number: 20190105337
    Abstract: Methods of treating or ameliorating a bacterial infection comprising administering a composition comprising a cyclic boronic acid ester Compound I in combination with meropenem are disclosed herewith. In some embodiments, the bacterial infection is a lower respiratory tract infection.
    Type: Application
    Filed: July 6, 2018
    Publication date: April 11, 2019
    Inventors: David C. Griffith, Michael N. Dudley, Jeffrey S. Loutit, Olga Lomovskaya
  • Use of aerosolized levofloxacin for treating cystic fibrosis
    Patent number: 10231975
    Abstract: Methods for treating cystic fibrosis. The method includes administering to a human in need thereof an aerosol solution comprising levofloxacin or ofloxacin and a divalent or trivalent cation. More particularly, the method includes administering the aerosol solution to a human having a pulmonary infection comprising P. aeruginosa.
    Type: Grant
    Filed: June 14, 2017
    Date of Patent: March 19, 2019
    Assignee: Horizon Orphan LLC
    Inventors: Jeffery S. Loutit, Elizabeth E. Morgan, Michael N. Dudley, David C. Griffith, Olga Lomovskaya
  • USE OF AEROSOLIZED LEVOFLOXACIN FOR TREATING CYSTIC FIBROSIS
    Publication number: 20180085376
    Abstract: Methods for treating cystic fibrosis. The method includes administering to a human in need thereof an aerosol solution comprising levofloxacin or ofloxacin and a divalent or trivalent cation. More particularly, the method includes administering the aerosol solution to a human having a pulmonary infection comprising P. aeruginosa.
    Type: Application
    Filed: June 14, 2017
    Publication date: March 29, 2018
    Inventors: Jeffery S. Loutit, Elizabeth E. Morgan, Michael N. Dudley, David C. Griffith, Olga Lomovskaya
  • Use of aerosolized levofloxacin for treating cystic fibrosis
    Patent number: 9700564
    Abstract: Methods for treating cystic fibrosis. The method includes administering to a human in need thereof an aerosol solution comprising levofloxacin or ofloxacin and a divalent or trivalent cation. More particularly, the method includes administering the aerosol solution to a human having a pulmonary infection comprising P. aeruginosa.
    Type: Grant
    Filed: March 5, 2012
    Date of Patent: July 11, 2017
    Assignee: Horizon Orphan LLC
    Inventors: Jeffery S. Loutit, Elizabeth E. Morgan, Michael N. Dudley, David C. Griffith, Olga Lomovskaya
  • METHODS OF TREATING BACTERIAL INFECTIONS
    Publication number: 20160339045
    Abstract: Methods of treating or ameliorating a bacterial infection comprising administering a composition comprising a cyclic boronic acid ester Compound I in combination with meropenem are disclosed herewith. In some embodiments, the bacterial infection is a lower respiratory tract infection.
    Type: Application
    Filed: April 20, 2016
    Publication date: November 24, 2016
    Inventors: David C. Griffith, Michael N. Dudley, Jeffrey S. Loutit, Olga Lomovskaya
  • Aerosolized fluoroquinolones and uses thereof
    Patent number: 8546423
    Abstract: Disclosed herein are formulations of fluoroquinolones suitable for aerosolization and use of such formulations for aerosol administration of fluoroquinolone antimicrobials for the treatment of pulmonary bacterial infections. In particular, inhaled levofloxacin specifically formulated and delivered for bacterial infections of the lungs is described. Methods include inhalation protocols and manufacturing procedures for production and use of the compositions described.
    Type: Grant
    Filed: October 22, 2009
    Date of Patent: October 1, 2013
    Assignee: MPEX Pharmaceuticals, Inc.
    Inventors: Mark W. Surber, Keith A. Bostian, Michael N. Dudley, Olga Lomovskaya, David C. Griffith
  • Aerosolized fluoroquinolones and uses thereof
    Patent number: 8524735
    Abstract: Disclosed herein are formulations of fluoroquinolones suitable for aerosolization and use of such formulations for aerosol administration of fluoroquinolone antimicrobials for the treatment of pulmonary bacterial infections. In particular, inhaled levofloxacin specifically formulated and delivered for bacterial infections of the lungs is described. Methods include inhalation protocols and manufacturing procedures for production and use of the compositions described.
    Type: Grant
    Filed: October 22, 2009
    Date of Patent: September 3, 2013
    Assignee: MPEX Pharmaceuticals, Inc.
    Inventors: Mark W. Surber, Keith A. Bostian, Michael N. Dudley, Olga Lomovskaya, David C. Griffith
  • Aerosolized fluoroquinolones and uses thereof
    Patent number: 8524734
    Abstract: Disclosed herein are formulations of fluoroquinolones suitable for aerosolization and use of such formulations for aerosol administration of fluoroquinolone antimicrobials for the treatment of pulmonary bacterial infections. In particular, inhaled levofloxacin specifically formulated and delivered for bacterial infections of the lungs is described. Methods include inhalation protocols and manufacturing procedures for production and use of the compositions described.
    Type: Grant
    Filed: October 22, 2009
    Date of Patent: September 3, 2013
    Assignee: MPEX Pharmaceuticals, Inc.
    Inventors: Mark W. Surber, Keith A. Bostian, Michael N. Dudley, Olga Lomovskaya, David C. Griffith
  • USE OF AEROSOLIZED LEVOFLOXACIN FOR TREATING CYSTIC FIBROSIS
    Publication number: 20120276153
    Abstract: Methods for treating cystic fibrosis. The method includes administering to a human in need thereof an aerosol solution comprising levofloxacin or ofloxacin and a divalent or trivalent cation. More particularly, the method includes administering the aerosol solution to a human having a pulmonary infection comprising P. aeruginosa.
    Type: Application
    Filed: March 5, 2012
    Publication date: November 1, 2012
    Applicant: MPEX PHARMACEUTICALS, INC.
    Inventors: Jeffery S. Loutit, Elizabeth E. Morgan, Michael N. Dudley, David C. Griffith, Olga Lomovskaya
  • Quaternary alkyl ammonium bacterial efflux pump inhibitors and therapeutic uses thereof
    Patent number: 8268865
    Abstract: Disclosed are compounds having at least one quaternary alkyl ammonium functionality. The compounds inhibit bacterial efflux pump inhibitors and are used in combination with an anti-bacterial agent to treat or prevent bacterial infections. These combinations can be effective against bacterial infections that have developed resistance to anti-bacterial agents through an efflux pump mechanism.
    Type: Grant
    Filed: May 6, 2008
    Date of Patent: September 18, 2012
    Assignee: Rempex Pharmaceuticals, Inc.
    Inventors: Tomasz Glinka, Olga Lomovskaya, Keith Bostian, David M. Wallace